Results 251 to 260 of about 1,686,019 (401)

Targeting UXS1‐Dependent Glucuronate Detoxification Potentiates Metformin's Anti‐Tumor Efficacy in Lung Adenocarcinoma

Advanced Science, EarlyView.
This study reveals that metformin promotes glucuronic acid metabolism in lung adenocarcinoma by activating UGDH S476 phosphorylation and enhancing the conversion of UDPG to UDPGA based on metabolomics analysis. Through compound virtual screening, it is found that plantainoside targeting UGDH downstream UXS1 leads to UDPGA toxicity accumulation ...
Qihai Sui, Zhencong Chen, Guangyao Shan, Zhengyang Hu, Xing Jin, Jiaqi Liang, Yanjun Yi, Jiacheng Yin, Haochun Shi, Xifei Jiang, Junjie Xi, Zongwu Lin, Cheng Zhan, Fenghao Sun, Wei Jiang   +14 more
wiley   +1 more source

Metabolic markers of kidney function and oxidative stress are associated with heart failure with preserved ejection fraction (HFpEF) in individuals with metabolic dysfunction-associated steatotic liver disease (MASLD). [PDF]

Metabolomics
Wegermann K, He M, Kwee LC, Newgard CB, Hnatyshyn S, Shipkova P, Shah SH, Moylan CA.   +7 more
europepmc   +1 more source

Table S6. Identified serum metabolites in HMUN and LMUN cows.

Zhao Xiaowei
openalex   +1 more source

Isolation of the phytotoxic metabolites of Pellicularia filamentosa

, 1963
Syoyo NISHIMURA, Mutsuo Sasaki
openalex   +2 more sources

Effects of in ovo injection of nano-selenium and nano-zinc oxide and high eggshell temperature during late incubation on antioxidant activity, thyroid and glucocorticoid hormones and some blood metabolites in broiler hatchlings

, 2020
Meisam Shokraneh, Ali Asghar Sadeghi, Seyed Naser Mousavi, Saeid Esmaeilkhanian, Mohammad Chamani   +4 more
openalex   +1 more source

Ultra-performance liquid chromatography coupled to electrospray ionization-tandem mass spectrometric method for simultaneous determination of acemetacin in presence of its metabolite indomethacin and degradation products [PDF]

, 2016
Maha Mahmoud Abou-El Alamin
openalex   +1 more source

Cellular Snowballing: Cell Adhesion and Migration Drive the Self‐Assembly of Cell‐Microgel Biohybrid Spheroids

Advanced Science, EarlyView.
A new class of biohybrid spheroids is engineered through the self‐assembly of adherent cells and extracellular matrix‐mimetic hydrogel microparticles (microgels). By mimicking a snowballing effect, this approach enables scalable formation of porous, millimeter‐scale spheroids with enhanced cell viability and molecular diffusion.
Zaman Ataie, Sina Kheirabadi, Changhao Li, Aneesh Risbud, Aswathy Sebastian, Istvan Albert, Sulin Zhang, Amir Sheikhi   +7 more
wiley   +1 more source

Cross-body site microbial interactions influence the human plasma metabolome. [PDF]

Microbiome
Zhang J, Jiang C, Zhou X, Gao P, Wong S, Snyder M, Shen X.   +6 more
europepmc   +1 more source

LC3B Mediated SETDB1‐Accounted Alcoholic Steatohepatitis via Lipidation‐Dependent LAP and Lipidation‐Independent Nuclear Stabilization

Advanced Science, EarlyView.
SETDB1 is progressively downregulated in ALD, correlating with disease severity. SETDB1 deficiency impairs LAP by disrupting Rubicon membrane localization, leading to defective lipid droplet clearance. Concurrently, loss of SETDB1 reduces nuclear LC3B, causing R‐loop accumulation and cGAS‐STING‐driven inflammation. Lipidated LC3B mediates LAP‐dependent
Yi Zhang, Tan Wei, Jiahang Wu, Chuixu Lin, Dongbo Zhu, Yanhui Li, Shuting Shi, Shishun Huang, Leiming Jiang, Hongzhi Wang, Meiqi Song, Pengfei Gao, Xu Wu, Mingjian Fan, Chaofeng Wei, Qian Wang, Lihui Qu, Zhigang Wang   +17 more
wiley   +1 more source

Spatiotemporal Metabolome analysis reveals a metabolic network during development of the waxy sorghum landrace 'Hongyingzi'. [PDF]

Front Plant Sci
Wang J, Li Q, Chen M, Chen Y, Peng Y, Yan S.   +5 more
europepmc   +1 more source