Results 271 to 280 of about 1,686,019 (401)

Understanding and Overcoming Antibody‐Drug Conjugate Resistance: Biological Mechanisms and Emerging Analytical Frameworks in Breast Cancer

Advanced Science, EarlyView.
Antibody–drug conjugates (ADCs) transform breast cancer therapy, yet resistance limits their durability. Emerging evidence reveals that ADC failure is not solely tumor‐intrinsic but shaped by dynamic tumor–microenvironment interactions that alter drug delivery, processing, and response.
Minji Seo, Jangsoon Lee, Naoto T. Ueno
wiley   +1 more source

Untargeted urinary metabolomics reveals metabolic alterations and severity biomarkers in cardiac surgery-associated acute kidney injury. [PDF]

Metabolomics
Lee CC, Hsieh YJ, Chang CH, Yu JS, Chen KH, Hung CC, Chen SW, Tu WJ, Chen YT.   +8 more
europepmc   +1 more source

Time‐Controlled Refrigerated Stem Cell Therapy Mitigates Scleroderma Fibrosis via Modulation of Mitochondrial Autophagy and Gut Metabolism

Advanced Science, EarlyView.
This study established an RT‐MSCs‐based therapeutic approach for scleroderma in mice. RT‐MSCs attenuated fibrosis by regulating mitochondrial autophagy and restored gut microbiota homeostasis. Metabolomic analyses confirmed recovery of key metabolites, and RT‐MSCs demonstrated favorable lesion targeting and safety profiles.
Xue Xia, Chenfei Kong, Xiaoming Zhao, Naixu Shi, Jinlan Jiang, Ping Li   +5 more
wiley   +1 more source

Comparative Microbiota and Metabolite Profiles of Undried and Dried Typica Luwak (Civet) Coffee Beans. [PDF]

Foods
Li M, Wang X, Ma L, Huang K, Tong T.
europepmc   +1 more source

Catching prompt metabolite dynamics of E. coli with the BioScope at oxygen rich conditions [PDF]

, 2010
Baart, Gino, De Mey, Marjan, Heijnen, Joseph J, Maertens, Jo, Soetaert, Wim, Taymaz-Nikerel, Hilal, van Gulik, Walter M, Waegeman, Hendrik   +7 more
core   +1 more source

Pharmacological profile of leukotrienes E4, N-acetyl E4 and of four of their novel omega- and beta-oxidative metabolites in airways of guinea-pig and man in vitro.

, 1989
Marwa N. Samhoun, Dolores M. Conroy, Priscilla J. Piper   +2 more
openalex  

Connection Between BMI-Related Plasma Metabolite Profile and Gut Microbiota

Journal of Clinical Endocrinology and Metabolism, 2018
F. Ottosson, L. Brunkwall, U. Ericson, P. Nilsson, P. Almgren, C. Fernandez, O. Melander, M. Orho-Melander   +7 more
semanticscholar   +1 more source

Rapid Remodeling of the Human Gut Microbiome in Response to Short‐Term Animal Product Restriction and Associations with Host Molecular Phenotypes

Advanced Science, EarlyView.
A real‐world model of structured animal product restriction practiced for religious reasons reveals the dynamic adaptability of the human gut microbiome to dietary change and uncovers reductions in diversity and rare taxa loss. Integrated microbiome, metabolomic, and proteomic analyses uncover coordinated taxonomic and molecular shifts and identify ...
Christina Emmanouil, Maria Anezaki, Alexandros Simistiras, Stavros Glentis, Nikolaos Scarmeas, Pantelis Hatzis, Konstantinos Rouskas, Antigone S. Dimas   +7 more
wiley   +1 more source

Commentary: Immunomodulatory role of gut microbial metabolites: mechanistic insights and therapeutic frontiers. [PDF]

Front Microbiol
Zeng Z, Wang Y, Fang D, Guo W.
europepmc   +1 more source

Metabolites and PCOS

, 2019
Shuliu Sun, Minjie Jiao, Chengcheng Han, Qian Zhang, Wenhao Shi, Juanzi Shi, Xiaojuan Li   +6 more
openalex   +1 more source