Results 281 to 290 of about 1,686,019 (401)

Halofuginone is a Molecular Glue Degrader of Integrin β4

Advanced Science, EarlyView.
Integrin β4 overexpression is linked to aggressive tumors and poor prognosis, but targeted therapies are lacking. We identified halofuginone (HF) as a molecular glue degrader that promotes integrin β4 degradation via the CRL4BWDR18 E3 ligase. HF suppresses tumor progression in vitro and in vivo, offering a new strategy for targeting oncogenic ...
Wei Gong, Di Yang, Junrui Tian, Yufei Chai, Tiantian Yu, Qingnan Wu, Yan Wang, Weimin Zhang, Qimin Zhan   +8 more
wiley   +1 more source

Single-Cell Metabolic Profiling in a Glioblastoma Coculture Model Using AP-MALDI-Based Mass Spectrometry Imaging. [PDF]

Anal Chem
Kontrimaite U, Wong KFC, Martínez-Jarquín S, McCrorie P, Rahman R, Kim DH.   +5 more
europepmc   +1 more source

Structural characterization of isomeric flavonoid glycosides and metabolites by metal complexation and electrospray ionization tandem mass spectrometry

, 2007
Barry D. Davis
openalex   +1 more source

Supporting data for “CEREBROSPINAL FLUID METABOLOMICS INPATIENTS WITH AND WITHOUT COGNITIVEIMPROVEMENT AFTER LYMPHATIC-VENOUSANASTOMOSIS SURGERY USING COMPLEMENTARYLIQUID CHROMATOGRAPHIC METHODS: FROMCONVENTIONAL METABOLITE BIOMARKERIDENTIFICATION TO COGNITIVE TEST-GUIDEDDISCOVERY USING CHEMOMETRIC APPROACHES”

Chao Lu
openalex   +1 more source

Metadata record for: A database of high-resolution MS/MS spectra for lichen metabolites

, 2019
Damien Olivier‐Jimenez, Marylène Chollet‐Krugler, David Rondeau, Mehdi A. Beniddir, Solenn Ferron, Thomas Delhaye, Pierre‐Marie Allard, Jean‐Luc Wolfender, Harrie J. M. Sipman, Robert Lücking, Joël Boustié, Pierre Le Pogam   +11 more
openalex   +1 more source

Targeting Peptostreptococcus anaerobius with an Iron‐Based Nanozyme Reverses Ferroptosis Resistance and Enhances Antitumor Immunity in Colorectal Cancer

Advanced Science, EarlyView.
An iron‐based nanozyme selectively eliminates intratumoral P. anaerobius while catalytically generating ROS to induce ferroptosis, synergistically suppressing colorectal cancer growth and activating anti‐tumor immunity through immunogenic cell death. ABSTRACT The intratumoral microbiota is a critical determinant of therapeutic outcomes in colorectal ...
Yinghao Cao, Jun Wang, Hanwenchen Wang, Xiang Sun, Fang Fang, Shiying Li, Jianping Liu, Changrong Shi, Pengyuan Qi, Jianhua Zou, Xiaoyuan Chen, Kailin Cai   +11 more
wiley   +1 more source

A perspective for alzheimer disease from gut microbiota-associated NMR-based fecal metabolomics: a study with 5XFAD mice. [PDF]

Metab Brain Dis
Tekin N, Şahin F, Şahin B, Kaya ZZ, Yılmaz A, Graham SF, Serteser M, Baykal AT.   +7 more
europepmc   +1 more source

Machine Learning for Green Solvents: Assessment, Selection and Substitution

Advanced Science, EarlyView.
Environmental regulations have intensified demand for green solvents, but discovery is limited by Solvent Selection Guides (SSGs) that quantify solvent sustainability. Training a machine learning model on GlaxoSmithKline SSG, a database of sustainability metrics for 10,189 solvents, GreenSolventDB is developed. Integrated with Hansen solubility metrics,
Rohan Datta, Janhavi Nistane, Abhishek Sose, Harikrishna Sahu, Rampi Ramprasad   +4 more
wiley   +1 more source

Circulating Microbial Metabolites Predict Tumor Relapse and Chemotherapy Efficacy in Nasopharyngeal Carcinoma. [PDF]

MedComm (2020)
Li JY, Yao Y, Tan XR, Si N, Jiang W, Lu YQ, Dai JH, Yu TT, Hu HC, Duan YF, Feng SY, Huang SW, Liang YL, Gong S, Liu N, Hu YM, Li YQ.   +16 more
europepmc   +1 more source

Randomized Trial of the Effects of Vitamin D on Tissue Vitamin D Metabolites and on Prostate Cancer Pathology

, 2014
Dennis Wagner
openalex   +1 more source