Results 301 to 310 of about 527,693 (324)
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Metabolites, enzymes, and metabolite analogues
1973The smallest change in the chemical constitution of a selectively toxic agent often makes an enormous change in its biological activity, and many examples of this have been given in Chapter 2. The present chapter deals in greater detail with one cause of high specificity, namely a close resemblance between (a) the normal substrate (or coenzyme) of an ...
Adrien Albert, Adrien Albert
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Journal of Pharmaceutical Sciences, 1974
Microbial transformation of the alkaloid mitragynine by the fungus Helminthosporum sp. has elaborated two major metabolites. The compounds were isolated from the biological milieu and their structures were elucidated as mitragynine pseudoindoxyl and hydroxy mitragynine pseudoindoxyl.
Joseph R. Valenta +3 more
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Microbial transformation of the alkaloid mitragynine by the fungus Helminthosporum sp. has elaborated two major metabolites. The compounds were isolated from the biological milieu and their structures were elucidated as mitragynine pseudoindoxyl and hydroxy mitragynine pseudoindoxyl.
Joseph R. Valenta +3 more
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The fungal metabolite austdiol [PDF]
Acta Crystallographica Section C Crystal Structure Communications, 2003 The title compound, (7R,8S)-7,8-dihydroxy-3,7-dimethyl-6-oxo-7,8-dihydro-6H-isochromene-5-carbaldehyde, C(12)H(12)O(5), is a trans-vicinal diol. Of the two fused rings, which lie approximately in the same plane, the pyran ring is almost perfectly planar, while the cyclohexenone ring adopts a slightly distorted half-chair conformation.
L. Lo Presti, R. Soave, R. Destro
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2015
Dichlorodiphenyltrichloroethane (DDT) is a well-known insecticide that was introduced and widely used during World War II. In total more than 4.5 million tonnes DDT have been produced. Although its use and production stopped worldwide during the 1970s, it was reintroduced in the 2000s as a malaria vector control by the World Health Organization (WHO ...
S. Mirmigkou, J. de Boer
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Dichlorodiphenyltrichloroethane (DDT) is a well-known insecticide that was introduced and widely used during World War II. In total more than 4.5 million tonnes DDT have been produced. Although its use and production stopped worldwide during the 1970s, it was reintroduced in the 2000s as a malaria vector control by the World Health Organization (WHO ...
S. Mirmigkou, J. de Boer
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Catecholamines and their metabolites
Journal of Chromatography B: Biomedical Sciences and Applications, 1988The research on biosynthesis, physiology, pharmacology, regulation and degradation of catecholamines has continuously increased for more than 50 years. This is not unexpected because of the fact that catecholamines are involved in so many life processes such as nerve conduction, blood circulation and hormone regulations in health and disease.
David S. Goldstein, Bertil K»gedal
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The Biosynthesis of Shikimate Metabolites
ChemInform, 1999AbstractFor Abstract see ChemInform Abstract in Full Text.
Andrew R. Knaggs +2 more
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Metabolite Damage and Metabolite Damage Control in Plants
Annual Review of Plant Biology, 2016It is increasingly clear that (a) many metabolites undergo spontaneous or enzyme-catalyzed side reactions in vivo, (b) the damaged metabolites formed by these reactions can be harmful, and (c) organisms have biochemical systems that limit the buildup of damaged metabolites.
Valérie de Crécy-Lagard +4 more
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Current Opinion in Microbiology, 1993
The extraordinary chemical diversity seen in the cyanobacteria (blue-green algae) is especially pronounced in the ubiquitous tropical marine species, Lyngbya majuscula. The gene clusters responsible for the production of some of the secondary metabolites have recently been elucidated.
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The extraordinary chemical diversity seen in the cyanobacteria (blue-green algae) is especially pronounced in the ubiquitous tropical marine species, Lyngbya majuscula. The gene clusters responsible for the production of some of the secondary metabolites have recently been elucidated.
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Mexiletine Metabolites: A Review
Current Medicinal Chemistry, 2015Mexiletine belongs to class IB antiarrhythmic drugs and it is still considered a drug of choice for treating myotonias. However some patients do not respond to mexiletine or have significant side effects limiting its use; thus, alternatives to this drug should be envisaged.
Catalano A., Carocci A., Sinicropi M. S.
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Deuteration of catecholamines, catecholamine metabolites and tryptophan metabolites
Journal of Labelled Compounds and Radiopharmaceuticals, 1978AbstractThe preparation of some deuterium labelled catecholamines, catecholamine metabolites and tryptophan metabolites is described. Simple exchange reactions in DC1/D20 solution or reductions with Li Al D4 were used. The deuterium labelled compounds prepared are suitable for use as internal standards for quantitative mass‐fragmentographic analysis of
Cg Thomasson +4 more
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