Results 31 to 40 of about 535,210 (299)

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Construction and Analysis of Human Diseases and Metabolites Network

Frontiers in Bioengineering and Biotechnology, 2020
The relationship between aberrant metabolism and the initiation and progression of diseases has gained considerable attention in recent years. To gain insights into the global relationship between diseases and metabolites, here we constructed a human ...
Kai Mi, Yanan Jiang, Yanan Jiang, Yanan Jiang, Jiaxin Chen, Dongxu Lv, Zhipeng Qian, Hui Sun, Desi Shang   +8 more
doaj   +1 more source

Shifts in Fecal Metabolite Profiles Associated With Ramadan Fasting Among Chinese and Pakistani Individuals

Frontiers in Nutrition, 2022
The human gut microbiota has been proposed to serve as a multifunctional organ in host metabolism, contributing effects to nutrient acquisition, immune response, and digestive health.
Siyu Chen, Ikram Ali, Ikram Ali, Xin Li, Danfeng Long, Ying Zhang, Ruijun Long, Xiaodan Huang   +7 more
doaj   +1 more source

Social context prevents heat hormetic effects against mutagens during fish development

FEBS Letters, EarlyView.
This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere, Claudio Silva De Freitas, Adam Bates, Kenneth B. Storey, Pedro Beltran‐Alvarez, Katharina C. Wollenberg Valero   +5 more
wiley   +1 more source

Recent Discovery of Heterocyclic Alkaloids from Marine-Derived Aspergillus Species

Marine Drugs, 2020
Nitrogen heterocycles have drawn considerable attention due to of their significant biological activities. The marine fungi residing in extreme environments are among the richest sources of these basic nitrogen-containing secondary metabolites. As one of
Kuo Xu, Xiao-Long Yuan, Chen Li, and Xiao-Dong Li   +3 more
doaj   +1 more source

Impacts of drought and elevated temperature on the seeds of malting barley

Frontiers in Plant Science, 2022
High seed quality is key to agricultural production, which is increasingly affected by climate change. We studied the effects of drought and elevated temperature during seed production on key seed quality traits of two genotypes of malting barley ...
Manuela Nagel, Erwann Arc, Loïc Rajjou, Gwendal Cueff, Marlene Bailly, Gilles Clément, Inmaculada Sanchez-Vicente, Christophe Bailly, Charlotte E. Seal, Thomas Roach, Hardy Rolletschek, Oscar Lorenzo, Andreas Börner, Ilse Kranner   +13 more
doaj   +1 more source

Metabolite Measurements [PDF]

, 2008
Metabolites are the products of enzyme-catalyzed reactions that occur naturally within living cells. Metabolites are synthesized by the cell for the purpose of performing a useful, if not indispensable, function in the maintenance and survival of the cells by, for example, contributing to its infrastructure or energy requirements.
Roessner, Ute, Beckles, Diane M
openaire   +3 more sources

Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation

FEBS Letters, EarlyView.
Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley   +1 more source

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

Biosensing materials for monoclonal antibody detection: An overview

Responsive Materials
Considering the continuous advances in the synthesis and clinical applications of monoclonal antibodies (mAbs), precision therapies that employ mAbs are essential.
Yuxin Zhang, Fang Fan, Yifeng Chai, Xiaofei Chen   +3 more
doaj   +1 more source