Results 81 to 90 of about 985,469 (331)

Limosilactobacillus reuteri-butyrate axis in depression therapy: A key pathway discovered through a novel preclinical human flora-associated animal model

Pharmacological Research
The transition from preclinical to clinical drug development is critically impeded by interspecies disparities, which limit the predictive validity of preclinical efficacy for human outcomes.
Xiaojing Liu, Jing He, Lixun Cui, Ying Ye, Miaomiao Luo, Hongzhan Xu, Yujia Zhai, Zixin Zhao, Taohong Huang, Yunxia Li, Jian-lin Wu, Jun Wen, Yong Wang, Tingting Zhou   +13 more
doaj   +1 more source

Remodeling of hepatic stellate cells orchestrated the stroma-derived oxaliplatin-resistance through CCN3 paracrine in hepatocellular carcinoma

BMC Cancer, 2019
Background Hepatic stellate cells (HSCs) have a key role in fibrogenesis and in the filtrates of the hepatocellular carcinoma (HCC) stroma, in which they are remodeled and play a critical role in HCC progression.
Xia Liao, Yang Bu, Fan Chang, Fengan Jia, Ge Song, Xuelian Xiao, Mei Zhang, Pengbo Ning, Qingan Jia   +8 more
doaj   +1 more source

Plasma metabolites reflect seasonally changing metabolic processes in a long-distance migrant shorebird (Calidris canutus) [PDF]

, 2002
Migrant birds have tightly scheduled annual cycles consisting of several distinct life cycle (sub-)stages such as reproduction, migration, moult and overwintering, each of which have specific metabolic requirements (e.g., fattening during migration ...
Jenni, Lukas,, Jenni-Eiermann, Susanne,, Piersma, Theunis,   +2 more
core   +2 more sources

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Feedbacks from the metabolic network to the genetic network reveal regulatory modules in E. coli and B. subtilis

, 2018
The genetic regulatory network (GRN) plays a key role in controlling the response of the cell to changes in the environment. Although the structure of GRNs has been the subject of many studies, their large scale structure in the light of feedbacks from ...
Jain, Sanjay, Kumar, Santhust, Mahajan, Saurabh   +2 more
core   +2 more sources

CSF metabolites associated with biomarkers of Alzheimer’s disease pathology [PDF]

, 2022
Ruocheng Dong, Qiongshi Lu, Hyunseung Kang, Ivonne Suridjan, Gwendlyn Kollmorgen, Norbert Wild, Yuetiva Deming, Carol A. Van Hulle, Rozalyn M. Anderson, Henrik Zetterberg, Kaj Blennow, Cynthia M. Carlsson, Sanjay Asthana, Sterling C. Johnson, Corinne D. Engelman   +14 more
openalex   +1 more source

Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion

FEBS Open Bio, EarlyView.
Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng, Souvik Datta, Derrick R. Samuelson   +2 more
wiley   +1 more source

Metabolomic analysis reveals key metabolites alleviating green spots by exogenous sucrose spraying in air-curing cigar tobacco leaves [PDF]

, 2022
Nanfen Li, Jun Yu, Jinpeng Yang, Sheliang Wang, Lianying Yu, Fangsen Xu, Chunlei Yang   +6 more
openalex   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Multinuclear NMR spectroscopy and isotopomer distribution analysis applied to metabolic phenotype characterization of complex systems [PDF]

, 2014
In the present work, the complex metabolic effects of a rag8 genetic mutation performed on Kluyveromyces lactis yeast cells is investigated with a specific, ‘information-rich’ analytical approach: differential NMR metabolomics. The use of such NMR-based
GORIETTI, DANIELA
core