Results 241 to 250 of about 1,454,594 (288)

UBE2T‐Driven p53 Degradation Rewires Glycolysis to Orchestrate Lactylation‐Mediated CAFs Activation and ECM Deposition in Pancreatic Cancer

Advanced Science, EarlyView.
This study integrates multi‐omics to reveal the critical role of UBE2T in driving malignancy and stromal co‐evolution in PDAC. UBE2T potentiates glycolysis by regulating p53 degradation via a positive feedback loop, thereby promoting histone H3 lysine 18 lactylation in CAFs and stromal deposition. The UBE2T inhibitor PGG represents a potential strategy
Yong Ma, Wenbo Liu, Mingdou Li, Tao Wang, Bin Zhao, Keshen Wang, Qichen He, Haonan Sun, Huiguo Qing, Xiaoying Guan, Wengui Shi, Long Qin, Yuman Dong, Huinian Zhou, Zeyuan Yu, Xiangyan Jiang, Zuoyi Jiao   +16 more
wiley   +1 more source

Small metabolites vary in sow milk across the course of lactation, while moringa supplementation and cooling sows exposed to heat stress conditions have limited effects. [PDF]

Transl Anim Sci
Reis LG, Stansberry MC, Ogundare W, Tobolski E, Beckett LM, Schinckel AP, Ferreira CR, Minor RC, Casey T.   +8 more
europepmc   +1 more source

Chloroplast Stress Signals Orchestrate Epidermis‐Specific Remodeling of Mitochondria and ER Under High Light

Advanced Science, EarlyView.
High light exposure triggers an epidermis‐specific remodeling of mitochondria and ER in Arabidopsis, driven by chloroplast‐derived signals. Live‐cell imaging shows that HL rapidly suppresses mitochondrial motility, followed by fusion‐driven elongation and ER cisternal expansion.
Evan R. Angelos, Hee‐Seung Choi, Jingzhe Guo, Andrea A. Zanini, Tessa M. Burch‐Smith, Emily Snyder, Matthew Part, Wilhelmina van de Ven, Manhoi Hur, Gerd Ulrich Balcke, Alain Tissier, Quanqing Zhang, Katayoon Dehesh   +12 more
wiley   +1 more source

Gut microbiota-derived EPA alleviates neuroinflammation associated with white matter injury by influencing H3K9ac/BDNF/TrkB pathway. [PDF]

Front Microbiol
Wang Y, Zhang Y, Cui Y, Zhu J, Wang C, Wang S, Xiao X, Yang L.   +7 more
europepmc   +1 more source

Profiling of the mycobiome and metabolome: a comparative study of benign pulmonary nodules and lung adenocarcinoma. [PDF]

Front Cell Infect Microbiol
Zhang W, Dong Y, Chen F, Wang F, Li J, Liu C, Liu T, Han L, Jia X.   +8 more
europepmc   +1 more source

Understanding the metabolome of four stress-relieving and cognitive-enhancing medicinal plants: a comprehensive HR-LC-ESI-MS/MS analysis. [PDF]

Metabolomics
Khan MN, Shah SMZ, Rahman S, Musharraf SG.   +3 more
europepmc   +1 more source

Non-targeted metabolomics reveals metabolic signatures associated with <i>Clostridioides difficile</i> virulence. [PDF]

Front Microbiol
Pan H, Zhang M, Zhao D, Wang Q, Shang H, Luo Y.   +5 more
europepmc   +1 more source

Plasma metabolomic signatures of all and cause-specific cancers: a multi-platform population-based study. [PDF]

Metabolomics
Shuai Y, Ruiter R, Stricker BH, Ikram MA, Ghanbari M.   +4 more
europepmc   +1 more source