Results 41 to 50 of about 1,454,594 (288)

Luteapyrone, a Novel ƴ-Pyrone Isolated from the Filamentous Fungus Metapochonia lutea

Molecules, 2021
In the process of screening for new bioactive microbial metabolites we found a novel ƴ-pyrone derivative for which we propose the trivial name luteapyrone, in a recently described microscopic filamentous fungus, Metapochonia lutea BiMM-F96/DF4.
Roman Labuda, Markus Bacher, Hannes Gratzl, Maria Doppler, Alexandra Parich, Mohammed Aufy, Rosa Lemmens-Gruber, Rainer Schuhmacher, Kathrin Rychli, Martin Wagner, Thomas Rosenau, Joseph Strauss, Christoph Schüller   +12 more
doaj   +1 more source

Human metabolism and elimination of the anthocyanin, cyanidin-3-glucoside: a 13C-tracer study [PDF]

, 2013
BACKGROUND: Evidence suggests that the consumption of anthocyanin-rich foods beneficially affects cardiovascular health; however, the absorption, distribution, metabolism, and elimination (ADME) of anthocyanin-rich foods are relatively unknown. OBJECTIVE:
Aedín Cassidy, Cassidy, Charles Czank, Colin D Kay, Das, Das, de Pascual-Teresa, Del Bò, Del Rio, Douglas J Morrison, Felgines, Felgines, Felgines, Garcia-Alonso, González-Barrio, Haycock, Hooper, Ichiyanagi, Kay, Kay, Kay, Manach, Mazza, McCullough, Milbury, Mink, Miyazawa, Morrison, Morrison, Morrison, Mullen, Neveu, Nigel P Botting, Nurmi, Paul A Kroon, Qingzhi Zhang, Shreeve, Slater, Tom Preston, Tsuda, Ueno, Vitaglione, Wallace, Walle, Williamson, Williamson, Woodward, Wu, Zhang, Zhang, Zhang   +50 more
core   +1 more source

Implication of metabolism in the polarization of tumor-associated-macrophages: the mass spectrometry-based point of view

Frontiers in Immunology, 2023
Tumor-associated macrophages (TAMs) represent one of the main tumor-infiltrating immune cell types and are generally categorized into either of two functionally contrasting subtypes, namely classical activated M1 macrophages and alternatively activated ...
Giulia De Simone, Giulia De Simone, Cristiana Soldani, Aurelia Morabito, Aurelia Morabito, Barbara Franceschini, Fabrizio Ferlan, Guido Costa, Guido Costa, Guido Costa, Roberta Pastorelli, Matteo Donadon, Matteo Donadon, Matteo Donadon, Matteo Donadon, Laura Brunelli   +15 more
doaj   +1 more source

Systemic Metabolomic Changes in Blood Samples of Lung Cancer Patients Identified by Gas Chromatography Time-of-Flight Mass Spectrometry. [PDF]

, 2015
Lung cancer is a leading cause of cancer deaths worldwide. Metabolic alterations in tumor cells coupled with systemic indicators of the host response to tumor development have the potential to yield blood profiles with clinical utility for diagnosis and ...
Barupal, Dinesh K, Fiehn, Oliver, Gandara, David R, Hanash, Samir M, Kim, Kyoungmi, Miyamoto, Suzanne, Taguchi, Ayumu, Taylor, Sandra L, Wikoff, William R, Wohlgemuth, Gert, Yoneda, Ken Y   +10 more
core   +2 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Analysis of Human Faecal Host Proteins: Responsiveness to 10-Week Dietary Intervention Modifying Dietary Protein Intake in Elderly Males

Frontiers in Nutrition, 2021
Faecal proteomics targeting biomarkers of immunity and inflammation have demonstrated clinical application for the identification of changes in gastrointestinal function.
Jessica L. Gathercole, Anita J. Grosvenor, Erin Lee, Ancy Thomas, Cameron J. Mitchell, Cameron J. Mitchell, Nina Zeng, Randall F. D'Souza, Randall F. D'Souza, Farha Ramzan, Pankaja Sharma, Scott O. Knowles, Nicole C. Roy, Nicole C. Roy, Nicole C. Roy, Nicole C. Roy, Nicole C. Roy, Anders Sjödin, Karl-Heinz Wagner, Amber M. Milan, Amber M. Milan, Sarah M. Mitchell, David Cameron-Smith, David Cameron-Smith   +23 more
doaj   +1 more source

Sensitivity of activated human lymphocytes to cyclosporine and its metabolites [PDF]

, 1988
Alloreactive T cells generated as clones from mixed lymphocyte cultures, or propagated from heart or liver transplant biopsies, were tested for secondary proliferation measured in the primed lymphocyte test in the presence of Cyclosporine A and ...
Burckart, G, Duquesnoy, RJ, Makowka, L, Murase, N, Starzl, TE, Van Thiel, DH, Venkataramanan, R, Wang, CP, Zeevi, A   +8 more
core   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Metabolomic analysis of human oral cancer cells with adenylate kinase 2 or phosphorylate glycerol kinase 1 inhibition. [PDF]

, 2017
The purpose of this study was to use liquid chromatography-mass spectrometry (LC-MS) with XCMS for a quantitative metabolomic analysis of UM1 and UM2 oral cancer cells after knockdown of metabolic enzyme adenylate kinase 2 (AK2) or phosphorylate glycerol
Cheng, Siliangyu, Cui, Li, Hu, Shen, Ji, Eoon Hye, Messadi, Diana, Yan, Xinmin, Yuan, Xiaoqing   +6 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source