Results 131 to 140 of about 1,692 (289)
Semina: Ciências Agrárias, 2014 The objective was to determine the efficiency of utilization of metabolizable energy for maintenance (km) and weight gain (kf), the dietary requirements of total digestible nutrients (TDN) and metabolizable protein (MP), as well as, evaluate the Small ...
Alessandra Pinto de Oliveira +8 more
doaj +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Efeito da energia da dieta e do peso ao desmame sobre o balanço de nitrogênio e metabolizabilidade da energia de leitões [PDF]
, 2018 This study aimed to evaluate the effects of dietary metabolizable energy (ME; 3.40, 3.60, or 3.80 Mcal/kg) and weaning weight (WW; 4.5 ± 0.4 and 6.7 ± 0.5 kg) on nitrogen balance (NB) and gross energy metabolizability in weanling piglets.
Batista, Anna Mikaela +3 more
core +1 more source
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source
The Amount of Metabolizable Glycine [PDF]
Agricultural and Biological Chemistry, 1972 Michihiro Sugahara, Makoto Kandatsu
openaire +1 more source
サツマイモ加工残さの飼料および食品利用に関する研究 [PDF]
, 2020 鹿児島大学博士(農学)Doctor of Philosophy博士論文全文, 博士論文要旨(English), 博士論文要旨(日本語), 最終試験結果の要旨, 論文審査の要旨doctoral ...
135787, Zhang, Xiaoxiao, 張, 暁霄
core
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source