Results 81 to 90 of about 45,136 (310)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Nutritional requirements of energy, protein and macrominerals for maintenance and weight gain of young crossbred Nellore × Holstein bulls on pasture. [PDF]

, 2017
The objective of this study was to estimate requirements of energy, protein and macrominerals of young Nellore/Holstein crossbreds bulls supplemented on pastures of Brachiaria decumbens Stapf.
CAVALI, J., COUTO, V. R. M., DETMANN, E., PAULINO, M. F., PORTO, M. O., SALES, M. F. L., VALADARES FILHO, S. de C., VALENTE, E. E. L.   +7 more
core  

Intake, growth and meat quality of steers given diets based on varying proportions of maize silage and grass silage [PDF]

, 2005
Simmental × Holstein-Friesian steers were offered four forage diets. These comprised grass silage (G); proportionately 0·67 grass silage, proportionately 0·33 maize silage (GGM); 0·33 grass silage, 0·67 maize silage ( MMG); maize silage ( M) from 424 (s ...
Beever, David, Browne, Elizabeth Mary, Bryant, Michael John, Fisher, Alan, Juniper, Darren Thomas, Nute, Geoff   +5 more
core   +1 more source

Modeling metabolizable energy utilization in broiler breeder pullets

Poultry Science, 2003
The objective of this study was to determine models for ME requirements for broiler breeder pullets using the factorial method. The influence of the temperature on maintenance ME requirements was determined by experiments conducted in three environmental rooms with temperature kept constant at 15,22, and 30 degrees C, using the comparative slaughter ...
Sakomura, N. K., Silva, R., Couto, H. P., Coon, C., Pacheco, C. R.   +4 more
openaire   +3 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Использование обменной энергии у бычков в период выращивания при разном уровне обменного протеина в рационе

Agricultural Science, 2019
Experimental investigations carried out using Kholmogory bulls, kept under vivarium conditions, have been aimed to study the effect of different levels of metabolizable protein in the diet on the use intensity of metabolizable energy.
ДЕНЬКИН Алексей , ЛЕМЕШЕВСКИЙ Виктор   +1 more
doaj  

Determination of Energy and Protein Requirements of Sheep in Indonesia Using a Meta-analytical Approach [PDF]

, 2017
The objective of this study was to determine energy and protein requirements, for both maintenance and gain, of sheep in Indonesia by using a meta-analysis method.
Astuti, D. A. (D), Jayanegara, A. (A), Laconi, E. B. (E), Nahrowi, N. (Nahrowi), Ridla, M. (M), Wiryawan, K. G. (K)   +5 more
core   +3 more sources

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Energy nutritional requirements for females of Nellore, Nellore × Angus and Nellore × Simmental fed on two forage: concentrate ratios

Revista Brasileira de Zootecnia, 2012
The objective of this study was to determine the energy nutritional requirements for females of Nellore, Nellore × Angus and Nellore × Simmental fed on two levels of concentrate. Sixty heifers from three genetic groups were used: 20 Nellore, 20 Nellore ×
Evaristo Jorge Oliveira de Souza, Sebastião de Campos Valadares Filho, Adriana Guim, Rilene Ferreira Diniz Valadares, Marcos Inácio Marcondes, Antonia Sherlânea Chaves Véras, Paloma de Melo Amaral, Tathyane Ramalho Santos   +7 more
doaj   +1 more source