Results 61 to 70 of about 17,446 (264)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
FEBS Letters, EarlyView.Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley +1 more source
Inclusion of leucaena leaf hay in the diet of laying hens during the growing phase
Acta Scientiarum: Animal Sciences, 2014 Current experiment evaluated the effects of inclusion of leucaena leaf hay (LLH) on the performance and nutrient digestibility of diets for laying hens during the growth phase (14-18 weeks).
Alexsandro Nunes Oliveira +5 more
doaj +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Intake and total apparent digestibility in lambs fed six maize varieties in the Brazilian Semiarid
Revista Brasileira de Zootecnia, 2011 The objective of this study was to evaluate the daily intake and total apparent digestibility of dry matter, organic matter, crude protein, gross energy, ether extract, neutral detergent fiber, acid detergent fiber, total and non-fibrous carbohydrates ...
Rafael Dantas dos Santos +5 more
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Metabolizable energy values of diets supplemented with xylanase determined with laying hens
Revista Brasileira de Zootecnia, 2012 The objective of this study was to evaluate the effect of the supplementation of xylanase in diets with reduced energy level on the apparent metabolizable energy corrected for nitrogen, determined with laying hens at 14, 36, 60 and 80 weeks of age.
Karina Márcia Ribeiro de Souza +6 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Measuring Metabolizable Energy with Mature Hens
Poultry Science, 1979 Abstract Metabolizable energy (ME) values of some ingredients were determined using laying hens. Diets used in these studies were composed primarily of the test ingredient plus minerals and vitamins. Mature hens, housed in separate cages, were permitted to adjust to each test diet for about 2 weeks, followed by a 3 or 4 day collection during which ...
M.G. DIN, M.L. SUNDE, H.R. BIRD
openaire +1 more source