Results 121 to 130 of about 41,870 (302)

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Diet crude protein content and sources for lactating dairy cattle Quantidades e formas de proteína dietética para vacas em lactação

Scientia Agricola, 2010
Feeding extra protein as an attempt to increase amino acid flux to the intestine may increase lactational performance of dairy cattle. The objective of this study was to compare lactating dairy cow diets containing 16% crude protein (CP), adequate in ...
Hugo Imaizumi, Flávio Augusto Portela Santos, Carla Maris Machado Bittar, Paulo Sérgio Correia, Júnio César Martinez   +4 more
doaj   +1 more source

Enhancing Metabolic Efficiency through Optimizing Metabolizable Protein Profile in a Time Progressive Manner with Weaned Goats as a Model: Involvement of Gut Microbiota. [PDF]

Microbiol Spectr, 2022
Wu J, Zhang X, Wang M, Zhou C, Jiao J, Tan Z.   +5 more
europepmc   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Nutritional requirements of energy, protein and macrominerals for maintenance and weight gain of young crossbred Nellore × Holstein bulls on pasture. [PDF]

, 2017
The objective of this study was to estimate requirements of energy, protein and macrominerals of young Nellore/Holstein crossbreds bulls supplemented on pastures of Brachiaria decumbens Stapf.
CAVALI, J., COUTO, V. R. M., DETMANN, E., PAULINO, M. F., PORTO, M. O., SALES, M. F. L., VALADARES FILHO, S. de C., VALENTE, E. E. L.   +7 more
core  

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Effect of Urea and Distillers Inclusion in Dry- Rolled Corn Based Diets on Heifer Performance and Carcass Characteristics [PDF]

, 2020
Crossbred heifers (n=96, BW = 810 ± 20) were utilized to evaluate the effects of increasing wet distillers grains plus solubles and urea inclusion in a dry rolled corn based finishing diet on performance and carcass characteristics.
Boyd, Bradley M., Erickson, Galen E., Foote, Andrew P., Hales, Kristin E.   +3 more
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Effects of Dried Distillers Grains in Supplements for Beef Cows During Late Gestation on Cow–Calf Performance and Metabolic Status

Animals
Forty multiparous Nellore cows, with an average body weight, body condition score, and gestation days of 533 ± 32 kg, 5.7 ± 0.4 points, and 198 days, respectively, were managed under continuous grazing on a Urochloa decumbens pasture and either received ...
Johnnatan Castro Cabral Gonçalves, Jean Marcelo Albuquerque, Edinael Rodrigues de Almeida, Luanna Carla Coelho, José Augusto Moura Godinho, Lilian Yukie Pacheco Toma, Matheus Fellipe de Lana Ferreira, Luciana Navajas Rennó, Cláudia Batista Sampaio, Edenio Detmann, Sidnei Antônio Lopes   +10 more
doaj   +1 more source