Results 131 to 140 of about 41,870 (302)

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

open access: yesMolecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute   +17 more
wiley   +1 more source

Composição corporal, exigências em proteína e energia para ganho de peso de caprinos em pastejo = Body composition, protein and energy requirements for weight gain of ½ boer ½ mixed-breed goat kids on pasture

open access: yesActa Scientiarum: Animal Sciences, 2008
Objetivou-se com este trabalho estimar a composição corporal e as exigências nutricionais em proteína e energia para ganho de peso de cabritos ½ Boer ½ SRD, na fase de crescimento, em pastejo na região semiárida. O experimento foi desenvolvido na fazenda‘
Giovanna Henriques da Nóbrega   +5 more
doaj  

Pre- and postpartum metabolizable protein supply: II. Effects on plasma amino acids and markers of tissue mobilization in transition Holstein dairy cows

open access: yesJournal of Dairy Science
: The influence of diet composition on the degree of adipose and lean muscle mobilization and concentrations of circulating AA has been demonstrated during the transition period.
T.A. Westhoff   +4 more
doaj   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

open access: yesMolecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller   +17 more
wiley   +1 more source

Effect of close-up metabolizable protein supply on colostrum yield, composition, and immunoglobulin G concentration and associations with prepartum metabolic indicators of Holstein cows

open access: yesJournal of Dairy Science
: The prepartum diet as well as individual metabolic status of the cow influences colostrum parameters. The objectives of this study were to (1) investigate the effect of increasing prepartum dietary MP supply on colostrum yield, composition, and IgG ...
T.A. Westhoff   +4 more
doaj   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola   +12 more
wiley   +1 more source

Aerial Inventories of Waterfowl in Illinois and Estimation of Moist-soil Plant Seed Abundance for Waterfowl on Lands Managed by Illinois Department of Natural Resources [PDF]

open access: yes, 2008
Grant/Contract No: W-43-R 53-54-55Reports on progress and results of inventories of waterfowl along the Illinois and central Mississippi rivers during fall and winter and estimation of moist-soil plant seed abundance for waterfowl on lands managed by ...
Hine, Christopher S.   +4 more
core  

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