Results 121 to 130 of about 98,733 (348)

Dietary supplementation with inulin-propionate ester or inulin improves insulin sensitivity in adults with overweight and obesity with distinct effects on the gut microbiota, plasma metabolome and systemic inflammatory responses: a randomised cross-over trial

Gut, 2019
Objective To investigate the underlying mechanisms behind changes in glucose homeostasis with delivery of propionate to the human colon by comprehensive and coordinated analysis of gut bacterial composition, plasma metabolome and immune responses. Design
E. Chambers, C. Byrne, D. Morrison, K. Murphy, T. Preston, Catriona Tedford, I. García-Pérez, Sofia Fountana, J. Serrano-Contreras, E. Holmes, C. Reynolds, Jordie F Roberts, R. Boyton, D. Altmann, J. McDonald, J. Marchesi, A. Akbar, N. Riddell, G. Wallis, G. Frost   +19 more
semanticscholar   +1 more source

Livestock metabolomics and the livestock metabolome: A systematic review

PLOS ONE, 2017
Metabolomics uses advanced analytical chemistry techniques to comprehensively measure large numbers of small molecule metabolites in cells, tissues and biofluids. The ability to rapidly detect and quantify hundreds or even thousands of metabolites within a single sample is helping scientists paint a far more complete picture of system-wide metabolism ...
Seyed Ali Goldansaz, An Chi Guo, Tanvir Sajed, Michael A. Steele, Graham S. Plastow, David S. Wishart   +5 more
openaire   +5 more sources

Pan‐cancer analysis shapes the understanding of cancer biology and medicine

Cancer Communications, EarlyView.
Abstract Advances in multi‐omics datasets and analytical methods have revolutionized cancer research, offering a comprehensive, pan‐cancer perspective. Pan‐cancer studies identify shared mechanisms and unique traits across different cancer types, which are reshaping diagnostic and treatment strategies.
Xiaoping Cen, Yuanyuan Lan, Jiansheng Zou, Ruilin Chen, Can Hu, Yahan Tong, Chen Zhang, Jingyue Chen, Yuanmei Wang, Run Zhou, Weiwei He, Tianyu Lu, Fred Dubee, Dragomirka Jovic, Wei Dong, Qingqing Gao, Man Ma, Youyong Lu, Yu Xue, Xiangdong Cheng, Yixue Li, Huanming Yang   +21 more
wiley   +1 more source

Unraveling the Evolutionary Diet Mismatch and Its Contribution to the Deterioration of Body Composition

Metabolites
Over the millennia, patterns of food consumption have changed; however, foods were always whole foods. Ultra-processed foods (UPFs) have been a very recent development and have become the primary food source for many people. The purpose of this review is
Sandi Assaf, Jason Park, Naveed Chowdhry, Meghasree Ganapuram, Shelbin Mattathil, Rami Alakeel, Owen J. Kelly   +6 more
doaj   +1 more source

Diversity of vaginal microbiome and metabolome during genital infections

Scientific Reports, 2019
We characterized the vaginal ecosystem during common infections of the female genital tract, as vulvovaginal candidiasis (VVC, n = 18) and Chlamydia trachomatis infection (CT, n = 20), recruiting healthy (HC, n = 21) and bacterial vaginosis-affected (BV,
Camilla Ceccarani, C. Foschi, C. Parolin, A. D’antuono, V. Gaspari, C. Consolandi, L. Laghi, T. Camboni, B. Vitali, M. Severgnini, A. Marangoni   +10 more
semanticscholar   +1 more source

Lipid metabolism reprograming by SREBP1‐PCSK9 targeting sensitizes pancreatic cancer to immunochemotherapy

Cancer Communications, EarlyView.
Abstract Background Pancreatic cancer's aberrant lipid metabolism fuels cell growth, invasion, and metastasis, yet its impact on immune surveillance and immunotherapy is unclear. This study investigated how sterol regulatory element‐binding transcription factor 1 (SREBP1)‐driven lipid metabolism affects the tumor microenvironment (TME) in pancreatic ...
Mengyi Lao, Xiaozhen Zhang, Zejun Li, Kang Sun, Hanshen Yang, Sicheng Wang, Lihong He, Yan Chen, Hanjia Zhang, Jiatao Shi, Daqian Xu, Tingbo Liang, Xueli Bai   +12 more
wiley   +1 more source

Combining genomics, metabolome analysis, and biochemical modelling to understand metabolic networks [PDF]

, 2001
Oliver Fiehn
openalex   +1 more source

Clade III Synthases Add Cyclic and Linear Terpenoids to the Psilocybe Metabolome

ChemBioChem, Volume 26, Issue 13, July 11, 2025.
The Psilocybe cubensis terpene synthases, CubB‐CubE, were investigated. Product formation assays identified CubB as a (3R,6E)‐(‐)‐nerolidol or linalool synthase, whereas CubC is a multiproduct synthase catalyzing the formation of β‐caryophyllene and other linear and cyclic sesquiterpenes/‐terpenoids.
Nick Zschoche, Sebastian Schober, Karl Walther, Andrew R. Chadeayne, Markus Gressler, Stefan Bartram, Sarah E. O’Connor, Dirk Hoffmeister   +7 more
wiley   +1 more source

Composition Characterization of Crossostephium chinense Leaf Essential Oil and Its Anti-Inflammatory Activity Mechanisms

Plants
This study investigates the composition characteristics and anti-inflammatory activity mechanisms of the essential oil from the leaves of Crossostephium chinense. C.
Chia-Hsin Lin, Yu-Ting Chiang, Li-Yin Lin, Nai-Wen Tsao, Chung-Hsuan Wang, Shih-Chang Chien, Ying-Hsuan Sun, Sheng-Yang Wang   +7 more
doaj   +1 more source

Capillary electrophoretic techniques toward the metabolome analysis [PDF]

, 2001
Shigeru Terabe, Michał J. Markuszewski, Naoko Inoue, Koji Otsuka, Takaaki Nishi­oka   +4 more
openalex   +1 more source