Results 141 to 150 of about 98,733 (348)

Plasma metabolomics identifies signatures that distinguish heart failure with reduced and preserved ejection fraction

ESC Heart Failure, EarlyView.
Abstract Aims Two general phenotypes of heart failure (HF) are recognized: HF with reduced ejection fraction (HFrEF) and with preserved EF (HFpEF). To develop phenotype‐specific approaches to treatment, distinguishing biomarkers are needed. The goal of this study was to utilize quantitative metabolomics on a large, diverse population to replicate and ...
Fawaz Naeem, Teresa C. Leone, Christopher Petucci, Clarissa Shoffler, Ravindra C. Kodihalli, Tiffany Hidalgo, Cheryl Tow‐Keogh, Jessica Mancuso, Iphigenia Tzameli, Donald Bennett, John D. Groarke, Rachel J. Roth Flach, Daniel J. Rader, Daniel P. Kelly   +13 more
wiley   +1 more source

Human metabolomics reveal daily variations under nutritional challenges specific to serum and skeletal muscle

Molecular Metabolism, 2018
Objective: Advances in the field of metabolomics and the concomitant development of bioinformatics tools constitute a promising avenue towards the development of precision medicine and personalized profiling for numerous disease states. Studies in animal
Shogo Sato, Evelyn B. Parr, Brooke L. Devlin, John A. Hawley, Paolo Sassone-Corsi   +4 more
doaj  

The light‐hyperresponsive high pigment‐2^dg mutation of tomato: alterations in the fruit metabolome [PDF]

, 2005
R.J. Bino, C. H. Ric De Vos, Michal Lieberman, Robert D. Hall, Arnaud Bovy, Harry Jonker, Yury Tikunov, Arjen Lommen, Sofia Moco, Ilan Levin   +9 more
openalex   +1 more source

Mechanical unloading is accompanied by reverse metabolic remodelling in the failing heart: Identification of a novel citraconate‐mediated pathway

European Journal of Heart Failure, EarlyView.
Aims Although functional recovery of the failing heart with left ventricular assist device (LVAD) unloading can occur, the underpinning mechanism is unclear. We aimed to characterize the effect of myocardial biochemical effect of LVAD support in vivo and in vitro.
David M. Kaye, Xiao Suo Wang, Yen Chin Koay, Mengbo Li, Bailey McIntosh, Yann Huey Ng, Michael Rahman, Yiyang Cao, Francine Z. Marques, Cassandra Malecki, Shane Nanayakkara, Justin Mariani, Bing Wang, Sean Lal, Giovanni Guglielmi, John F. O'Sullivan   +15 more
wiley   +1 more source

Depth of Interbreed Difference in Postmortem Bovine Muscle Determined by CE-FT/MS and LC-FT/MS Metabolomics

Metabolites
Japanese Brown (JBR) cattle have moderately marbled beef compared to the highly marbled beef of Japanese Black (JBL) cattle; however, their skeletal muscle properties remain poorly characterized.
Susumu Muroya, Yuta Horiuchi, Kazuki Iguchi, Takuma Higuchi, Shuji Sakamoto, Koichi Ojima, Kazutsugu Matsukawa   +6 more
doaj   +1 more source

Evaluating different extraction solvents for GC-MS based metabolomic analysis of the fecal metabolome of adult and baby giant pandas

Scientific Reports, 2019
The gut microbiome plays a fundamental role in host health and the fecal metabolome can be analysed to assess microbial activity and can be used as an intermediate phenotype monitoring the host-microbiome relationship.
Yang Yang, Yanqiang Yin, Xuyang Chen, Chang Chen, Yinyin Xia, Hongbo Qi, Philip N. Baker, Hua Zhang, Ting-Li Han   +8 more
doaj   +1 more source

MetaQuant: a tool for the automatic quantification of GC/MS-based metabolome data [PDF]

, 2006
Boyke Bunk, Martin Kucklick, Rochus Jonas, Richard Münch, Max Schobert, Dieter Jahn, Karsten Hiller   +6 more
openalex   +1 more source

Intestinal microbiome alterations in pediatric epilepsy: Implications for seizures and therapeutic approaches

Epilepsia Open, EarlyView.
Abstract The intestinal microbiome plays a pivotal role in maintaining host health through its involvement in gastrointestinal, immune, and central nervous system (CNS) functions. Recent evidence underscores the bidirectional communication between the microbiota, the gut, and the brain and the impact of this axis on neurological diseases, including ...
Teresa Ravizza, Greta Volpedo, Antonella Riva, Pasquale Striano, Annamaria Vezzani   +4 more
wiley   +1 more source

Sputum Microbiota Compositions Correlate With Metabolome and Clinical Outcomes of COPD‐Bronchiectasis Association: A Prospective Cohort Study

Exploration, EarlyView.
This study aimed to determine how microbiota compositions (via 16S rRNA sequencing) correlate with clinical outcome and metabolome (via liquid chromatography/mass spectrometry) of CBA. Sputum microbiome and metabolome profiles of CBA were well separated from COPD but not bronchiectasis, partly driven by the higher abundance of Proteobacteria in CBA ...
Zhen‐feng He, Xiao‐xian Zhang, Cui‐xia Pan, Xin‐zhu Yi, Yan Huang, Chun‐lan Chen, Shan‐shan Zha, Lai‐jian Cen, Han‐qin Cai, Lei Yang, Jia‐qi Gao, Hui‐min Li, Zhen‐hong Lin, Sheng‐zhu Lin, Zhang Wang, Nan‐shan Zhong, Wei‐jie Guan   +16 more
wiley   +1 more source

Corrigendum: Development of a polyphagous leaf beetle on different host plant species and its detoxification of glucosinolates

Frontiers in Ecology and Evolution, 2023
Jeanne Friedrichs, Rabea Schweiger, Svenja Geisler, Judith M. Neumann, Sullivan J. M. Sadzik, Karsten Niehaus, Caroline Müller   +6 more
doaj   +1 more source