Results 141 to 150 of about 297,367 (349)

Metabolomics: what's new? [PDF]

Flavour and Fragrance Journal, 2010
Verpoorte, R., Choi, Y.H., Kim, H.K.
openaire   +2 more sources

Minimally Invasive Chemical Biopsy Needle with Self‐Wettable Extraction Phase For In Vivo Tissue Sampling During Medical Procedures

Advanced Science, EarlyView.
A new tissue sampling device using an acupuncture needle with bio‐compatible extraction sorbents in the recessed section is developed. The coating material using self‐wettable particles doesn't require solvent activation after sterilization. This device is applied for the anti‐cancer drug concentration monitoring during the in vivo lung perfusion ...
Runshan Will Jiang, Wei Zhou, Marcelo Cypel, Todd L. Demmy, Gal Shafirstein, Guillermo Garza, Emily Gawrys, Joanna Bogusiewicz, Barbara Bojko, Janusz Pawliszyn   +9 more
wiley   +1 more source

eIF2α phosphorylation: A hallmark of immunogenic cell death

OncoImmunology, 2018
Immunogenic cell death (ICD) induced by anticancer chemotherapeutics is usually preceded by premortem stress affecting the endoplasmic reticulum (ER). This ER stress does not reflect a canonical unfolded protein response (UPR) but rather manifests solely
Lucillia Bezu, Allan Sauvat, Juliette Humeau, Marion Leduc, Oliver Kepp, Guido Kroemer   +5 more
doaj   +1 more source

Nuclear Magnetic Resonance Spectroscopy Metabolomics in Idiopathic Intracranial Hypertension to Identify Markers of Disease and Headache [PDF]

, 2022
Olivia Grech, Senali Y. Seneviratne, Zerin Alimajstorovic, Andreas Yiangou, James Mitchell, Thomas B. Smith, Susan P. Mollan, Gareth G. Lavery, Christian Ludwig, Alexandra J. Sinclair   +9 more
openalex   +1 more source

Predicting Immunotherapy Outcomes in NSCLC Using RNA and Pathology from Multicenter Clinical Trials

Advanced Science, EarlyView.
LIRA, a machine learning‐based model, is developed using transcriptomic data from 891 NSCLC patients in the OAK and POPLAR cohorts. Its predictive performance is validated in multiple external cohorts. Patients stratified by LIRA‐score exhibit distinct clinical characteristics and tumor microenvironment profiles.
Zhaojun Wang, Yiran Fang, Xiatong Huang, Guichuang Ma, Qianqian Mao, Xiansheng Lu, Guangda Rong, Yunfang Yu, Yuanyuan Wang, Zhenhua Huang, Huiying Sun, Jiani Wu, Wenchao Gu, Na Huang, Jianhua Wu, Rui Zhou, Xiaoxiang Rong, Siting Zheng, Shaowei Li, Gaofeng Wang, Ling Wang, Wenjun Qiu, Luyang Jiang, Peng Luo, Yonggang Liu, Jianping Bin, Yulin Liao, Min Shi, Zuqiang Wu, Jiguang Wang, Wangjun Liao, Gang Chen, Dongqiang Zeng   +32 more
wiley   +1 more source

Biomarkers of glucose-insulin homeostasis and incident type 2 diabetes and cardiovascular disease: results from the Vitamin D and Omega-3 trial

Cardiovascular Diabetology
Background Dysglycemia and insulin resistance increase type 2 diabetes (T2D) and cardiovascular disease (CVD) risk, yet associations with specific glucose-insulin homeostatic biomarkers have been inconsistent.
Frank Qian, Yanjun Guo, Chunying Li, Yanyan Liu, Heike Luttmann-Gibson, Natalya Gomelskaya, Olga V. Demler, Nancy R. Cook, I-Min Lee, Julie E. Buring, Julia Larsen, Jennifer Boring, Michael J. McPhaul, JoAnn E. Manson, Aruna D. Pradhan, Samia Mora   +15 more
doaj   +1 more source

Datopotamab deruxtecan induces hallmarks of immunogenic cell death

Cell Stress
Antibody-drug conjugates (ADCs) offer a strategy for targeted delivery of cytotoxic agents to cancer cells. In this study, we investigated the mechanism of action of datopotamab deruxtecan, an ADC composed of a monoclonal antibody targeting tumor ...
Sabrina Forveille, Marion Leduc, Allan Sauvat, Guido Kroemer, Oliver Kepp   +4 more
doaj   +1 more source

Mass spectrometry-based metabolomics in microbiome investigations

Nature Reviews Microbiology, 2021
A. Bauermeister, H. Mannochio-Russo, Letícia V. Costa-Lotufo, A. Jarmusch, P. Dorrestein   +4 more
semanticscholar   +1 more source

What Did We Learn From Plant Growth-Promoting Rhizobacteria (PGPR)-Grass Associations Studies Through Proteomic and Metabolomic Approaches? [PDF]

, 2020
Dayane Alberton, Gláucio Valdameri, Vivian Rotuno Moure, Rose Adele Monteiro, Fábio de Oliveira Pedrosa, Marcelo Müller‐Santos, Emanuel Maltempi de Souza   +6 more
openalex   +1 more source

Realgar‐Induced CNS Toxicity: Exploring OTC‐Mediated Ornithine Regulation of ZBTB7A Inhibits Astrocyte Glycolysis Based on the Liver–Brain Axis

Advanced Science, EarlyView.
Arsenic in realgar induces CNS toxicity through direct and indirect effects: it activates ZBTB7A in astrocytes, which in turn inhibits glycolysis and impairs mice's learning, memory, and exploration; it also suppresses OTC in the liver to block the ornithine cycle, leading to blood ornithine accumulation that crosses into the frontal lobe and further ...
Ping Ye, Zhen Li, Huanyong Fu, Shuai Wang, Xingang Cui, Chengbo Song, Chao Ma, Hong Jiang   +7 more
wiley   +1 more source