Results 151 to 160 of about 393,797 (377)

The activation of PPARγ by 2,4,6-Octatrienoic acid protects human keratinocytes from UVR-induced damages

Scientific Reports, 2017
Increasing attention is addressed to identify products able to enhance skin photoprotection and to prevent skin carcinogenesis. Several studies have demonstrated that the α-melanocyte stimulating hormone (αMSH), acting on a functional MC1R, provides a ...
Enrica Flori, Arianna Mastrofrancesco, Daniela Kovacs, Barbara Bellei, Stefania Briganti, Vittoria Maresca, Giorgia Cardinali, Mauro Picardo   +7 more
doaj   +1 more source

Mass spectrometry-based metabolomics: a guide for annotation, quantification and best reporting practices

Nature Methods, 2021
S. Alseekh, A. Aharoni, Y. Brotman, K. Contrepois, J. D’Auria, Jan Ewald, Jennifer C Ewald, P. Fraser, Patrick Giavalisco, R. Hall, Matthias Heinemann, H. Link, Jie Luo, S. Neumann, J. Nielsen, Leonardo Perez de Souza, K. Saito, U. Sauer, F. Schroeder, S. Schuster, G. Siuzdak, A. Skirycz, L. Sumner, M. Snyder, Huiru Tang, Takayuki Tohge, Yulan Wang, Weiwei Wen, Si Wu, Guowang Xu, Nicola Zamboni, A. Fernie   +31 more
semanticscholar   +1 more source

metaX: a flexible and comprehensive software for processing metabolomics data

BMC Bioinformatics, 2017
Non-targeted metabolomics based on mass spectrometry enables high-throughput profiling of the metabolites in a biological sample. The large amount of data generated from mass spectrometry requires intensive computational processing for annotation of mass
B. Wen, Zhanlong Mei, Chunwei Zeng, Siqi Liu   +3 more
semanticscholar   +1 more source

19 F NMR metabolomics for the elucidation of microbial degradation pathways of fluorophenols [PDF]

, 2001
Marelle G. Boersma, Inna I. P. Solyanikova, Willem J. H. van Berkel, Jacques Vervoort, L. A. Golovleva, Ivonne M.C.M. Rietjens   +5 more
openalex   +1 more source

PSMD14 Stabilizes SLC7A11 to Ameliorate Glucocorticoid‐Induced Osteoporosis by Suppressing Osteocyte Ferroptosis

Advanced Science, EarlyView.
Glucocorticoid‐induced osteoporosis (GIOP) triggers osteocyte ferroptosis via SLC7A11 degradation. PSMD14 stabilizes SLC7A11 by counteracting glucocorticoid‐driven ubiquitination, preserving cystine uptake and glutathione synthesis. AAV‐mediated PSMD14 delivery or its agonist Pantethine rescues osteocyte survival and bone loss in GIOP mice.
Yifeng Shi, Qian Tang, Sunren Sheng, Hongyi Jiang, Chen Jin, Chencheng Zhou, Chenglong Xie, Lin Zheng, Di Zhang, Hui Xu, Cong Xu, Haiwei Ma, Guangheng Xiang, Wenfei Ni, Xiaoyun Pan, Lei Yang, Huazi Xu, Yu Qian, Aimin Wu, Xiangyang Wang, Gang Zheng   +20 more
wiley   +1 more source

The α-melanocyte stimulating hormone/peroxisome proliferator activated receptor-γ pathway down-regulates proliferation in melanoma cell lines

Journal of Experimental & Clinical Cancer Research, 2017
Background The α-Melanocyte Stimulating Hormone (αMSH)/Melanocortin-1 receptor (MC1R) interaction promotes melanogenesis through the cAMP/PKA pathway.
Enrica Flori, Eleonora Rosati, Giorgia Cardinali, Daniela Kovacs, Barbara Bellei, Mauro Picardo, Vittoria Maresca   +6 more
doaj   +1 more source

WikiPathways: a multifaceted pathway database bridging metabolomics to other omics research

Nucleic Acids Res., 2017
WikiPathways (wikipathways.org) captures the collective knowledge represented in biological pathways. By providing a database in a curated, machine readable way, omics data analysis and visualization is enabled.
D. Slenter, M. Kutmon, K. Hanspers, Anders Riutta, Jacob Windsor, Nuno Nunes, Jonathan Mélius, Elisa Cirillo, S. Coort, Daniela Digles, F. Ehrhart, P. Giesbertz, Marianthi Kalafati, Marvin Martens, Ryan A Miller, Kozo Nishida, Linda Rieswijk, A. Waagmeester, L. Eijssen, C. Evelo, Alexander R. Pico, Egon Willighagen   +21 more
semanticscholar   +1 more source

Targeted Delivery of α‐ketoglutarate to Macrophages in Bone: A Novel Therapeutic Strategy for Improving Fracture Healing in Type 2 Diabetes

Advanced Science, EarlyView.
The study reveals that glutaminolysis in macrophages is inhibited under type 2 diabetes mellitus (T2DM) conditions, which impedes fracture healing by reducing bone morphogenetic protein 2 (BMP2) production through increased cytosine methylation on the promoter.
Jing Wang, Jiahao Cao, Siqi Zhang, Hongli Chen, Xuebing Yu, Xinli Wang, Tianji Wang, Wei Cao, Wengang Dong, Xinsen Lin, Jia Li, Wei Lei, Yafei Feng   +12 more
wiley   +1 more source

Radical Oxygen Species, Oxidized Low-Density Lipoproteins, and Lectin-like Oxidized Low-Density Lipoprotein Receptor 1: A Vicious Circle in Atherosclerotic Process

Antioxidants
Atherosclerosis is a complex condition that involves the accumulation of lipids and subsequent plaque formation in the arterial intima. There are various stimuli, cellular receptors, and pathways involved in this process, but oxidative modifications of ...
Marco Munno, Alice Mallia, Arianna Greco, Gloria Modafferi, Cristina Banfi, Sonia Eligini   +5 more
doaj   +1 more source

Plant metabolomics: large-scale phytochemistry in the functional genomics era [PDF]

, 2003
Lloyd W. Sumner, Pedro Mendes, Richard A. Dixon   +2 more
openalex   +1 more source