Results 201 to 210 of about 210,196 (287)

The Gut Commensal Butyricimonas Virosa Modulates Gut Microbiota‐Dependent Thiamine Metabolism and Attenuates Mouse Steatotic Liver Disease

Advanced Science, EarlyView.
This study reveals that dietary stachyose enriches Butyricimonas virosa, effectively attenuating metabolic dysfunction‐associated steatotic liver disease (MASLD). Mechanistically, B. virosa enhances gut thiamine monophosphate synthesis, which elevates hepatic thiamine pyrophosphate levels.
Ningning He, Haoyu Wang, Zizhen Yang, Hui Li, Bei Liu, Kaiwei Chen, Zhinan Wu, Xinnan Zhao, Hewei Liang, Mengmeng Wang, Xiaofang Li, Yiyi Zhong, Haifeng Zhang, Liang Xiao, Karsten Kristiansen, Jixing Peng, Yuanqiang Zou, Shangyong Li   +17 more
wiley   +1 more source

The Dark Metabolome/Lipidome and In‐Source Fragmentation

Analytical Science Advances
Winnie Uritboonthai, Linh Hoang, Aries Aisporna, Martin Giera, Gary Siuzdak   +4 more
doaj   +1 more source

A Scalable Organoid Model of Urothelial Aging for Metabolic Interrogation, Infection Modeling, and Reversal of Age-Associated Changes. [PDF]

Aging Cell
Parab AR, Salazar AM, Bark SJ, Divenko M, Putluri V, Lieu DJ, Singh AS, Putluri N, Mysorekar IU.   +8 more
europepmc   +1 more source

Development of Dimethylsulfonium Probes for Broad Profiling of Methyllysine Reader Proteins

Advanced Science, EarlyView.
Development of oligoglycine‐based dimethylsulfonium probes for unbiased crosslinking to methyllysine readers. The general probe facilitates profiling of site‐specific methyllysine readers, evaluation of selectivity and activity of reader inhibitors, and global profiling of methyllysine readers.
Jinyu Yang, Yihang Xiao, Yingxiao Gao, Mingxuan Wu   +3 more
wiley   +1 more source

Laboratory diagnostics: Maximizing sensitivity of a Q-Exactive Orbitrap mass spectrometer for untargeted metabolomics of dried blood spots

, 2017
Hanne Bendiksen Skogvold
openalex   +1 more source

Co-culture metabolomics: a powerful tool for uncovering host-pathogen phenotypes driving <i>Burkholderia</i> infections. [PDF]

mSystems
Bishop SL.
europepmc   +1 more source

F13A1‐Mediated Macrophage Activation Promotes MASH Progression via the PKM2/HIF1A Pathway

Advanced Science, EarlyView.
In fatty liver disease, hepatocytes exposed to palmitate release S1P, which activates calcium signaling in macrophages. Elevated calcium enhances the activity of F13A1, driving PKM2 dimerization. The PKM2 dimers cause Warburg effect, translocate to the nucleus, cooperate with HIF1A, and upregulate IL1B expression, ultimately promoting classical ...
Qianrang Lu, Meiching Ong, Xuewen Yi, Muqiong Xing, Xinyao Tian, Ke Zhang, Ling Lu, Hao Wang, Xiaohan Lin, Jun Fang, Aibo Mu, Jiaying Cao, Jingyu Jiang, Feng Gao, Hongjun Li, Baohong Wang, Qi Ling   +16 more
wiley   +1 more source

Quantitative Descriptive Analysis, Non-Targeted Metabolomics and Molecular Docking Reveal the Dynamic Aging and Taste Formation Mechanism in Raw Pu-Erh Tea During the Storage

Bingsong Ma, Cunqiang Ma, Binxing Zhou, Xuan Chen, Yuhua Wang, Yifan Li, Jun‐Feng Yin, Xinghui Li   +7 more
openalex   +1 more source

Metabolomic profiles associated with physiological resistance to Sclerotinia sclerotiorum (Lib.) de Bary in common bean

, 2015
F. Robison, Brick, Mark, Prenni, Jessica, Schwartz, Howard, Byrne, Pat, Heuberger, Adam   +5 more
openalex   +2 more sources

UMI-77 Ameliorates Lipopolysaccharide-Induced Sepsis-Associated Encephalopathy by Modulating the Brain-Gut Axis. [PDF]

Brain Behav
Ke Y, Dong C, Liu C, Ni M, Chen Y, Zhang Y, Wang Y, Xu Y, Chen G.   +8 more
europepmc   +1 more source