Results 221 to 230 of about 297,367 (349)

Dysregulation of Amino Acid, Lipid, and Acylpyruvate Metabolism in Idiopathic Intracranial Hypertension: A Non-targeted Case Control and Longitudinal Metabolomic Study

, 2022
Zerin Alimajstorovic, Susan P. Mollan, Olivia Grech, James Mitchell, Andreas Yiangou, Mark Thaller, Hannah Lyons, Matilde Sassani, Senali Y. Seneviratne, Thomas P. M. Hancox, Andris Jankevics, Lukáš Najdekr, Warwick B. Dunn, Alexandra J. Sinclair   +13 more
openalex   +1 more source

Uric Acid Functions as an Endogenous Modulator of Microglial Function and Amyloid Clearance in Alzheimer's Disease

Advanced Science, EarlyView.
Higher serum UA levels are associated with reduced AD risk in epidemiological studies. UA enhances microglial phagocytic capacity primarily by restoring CD36 and TREM2 receptor recycling that is impaired by Aβ exposure. Therapeutically, UA supplementation improves cognitive function and reduces neuropathology in AD mouse model by enhancing microglial ...
De Xie, Qiuyang Zheng, Jiaming Lv, Qian Zhang, Zhiwei Cui, Shuai Huang, Wei Yu, Binyang Chen, Wanling Que, Shanpan Fu, Yuemei Xi, Jiayu Chen, Xueling Ye, Shuyi Chen, Hairong Zhao, Tetsuya Yamamoto, Hidenori Koyama, Xin Wang, Jidong Cheng   +18 more
wiley   +1 more source

Determination of Untargeted Metabolomic Profile in Breath Condensate Using LC-QTOF/MS and Investigation of Potential Lung Cancer-Specific Biomarkers. [PDF]

Thorac Res Pract
Cakan Yildirim E, Pelit F, Korba K, Salan MA, Goksel T, Pelit L.   +5 more
europepmc   +1 more source

Identification of bioactive metabolites using activity metabolomics

Nature reviews. Molecular cell biology, 2019
Markus M. Rinschen, J. Ivanisevic, M. Giera, G. Siuzdak   +3 more
semanticscholar   +1 more source

Metabolomic signature of arterial stiffness in male patients with peripheral arterial disease [PDF]

, 2015
Maksim Zagura, Jaak Kals, Kalle Kilk, Martin Serg, Priit Kampus, Jaan Eha, Ursel Soomets, Mihkel Zilmer   +7 more
openalex   +1 more source

Skeletal Muscle HSF1 Alleviates Age‐Associated Sarcopenia and Mitochondrial Function Decline via SIRT3‐PGC1α Axis

Advanced Science, EarlyView.
Aged HSF1 muscle‐specific knockout mice show deteriorated muscle atrophy and metabolic dysfunction, while active HSF1 overexpression improves muscle function via activating SIRT3 to deacetylate both PGC1α1 and PGC1α4, which boosts mitochondrial function and muscle hypertrophy in a fiber‐type specific manner, and induces FNDC5/Irisin for tissue ...
Jun Zhang, Min Hu, Xia Wu, Mingwei Guo, Ying Ma, Jin Qiu, Siqi Wang, Yuxiang Cao, Yinzhao Zhong, Fangfang Chen, Yiwen Wang, Wei Wei, Yan Lu, Yong Zhang, Junjie Xiao, Zhenji Gan, Cheng Hu, Xinran Ma, Lingyan Xu   +18 more
wiley   +1 more source

Metabolomics in autoimmune hepatitis: progress and perspectives. [PDF]

Front Med (Lausanne)
Huang X, Mo W, Wang X.
europepmc   +1 more source

Lung cancer metabolomic data from tumor core biopsies enables risk-score calculation for progression-free and overall survival

, 2022
Hunter A. Miller, N. Shesh, Xinmin Yin, Xiang Zhang, Jason Chesney, Victor H. van Berkel, Hermann B. Frieboes   +6 more
openalex   +2 more sources

Lactylation Enhances the Activity of Lactate Dehydrogenase A and Promotes the Chemoresistance to Cisplatin Through Facilitating DNA Nonhomologous End Junction in Lung Adenocarcinoma

Advanced Science, EarlyView.
Lactylation, linked to glycolysis, is poorly understood in regulation. It is found that LDHA is lactylated at Lys81/Lys318 by AARS1, boosting its activity and cellular lactylation via positive feedback in LUAD. Lactylation regulates NHEJ‐related proteins; their delactylation impairs NHEJ and increases cisplatin sensitivity, offering anticancer insights.
Jizhuo Li, Wenze Xun, Xijie Wang, Ruiguang Luo, Qifan Hu, Zhaocai Zhou, Jian Yuan, Yanan Wang, Xiaorui Wan, Tao Zhao, Tianyu Han, Jian‐Bin Wang   +11 more
wiley   +1 more source

The SIMPLIFY Protocol: A Monophasic Extraction System Suitable for Exposomics, Metabolomics, Lipidomics, and Proteomics Research. [PDF]

Anal Chem
Nguyen AH, Castro-Alves V, Holmström Flores E, Barbosa JMG, Kråkström M, Reinivuori P, Kauko O, Dickens A, Orešič M, Hyötyläinen T.   +9 more
europepmc   +1 more source