Results 271 to 280 of about 393,797 (377)

Flux Sampling Suggests Metabolic Signatures of High Antibody‐Producing CHO Cells

open access: yesBiotechnology and Bioengineering, EarlyView.
ABSTRACT Chinese hamster ovary (CHO) cells remain the industry standard for producing numerous therapeutic proteins, particularly monoclonal antibodies (mAbs). However, achieving higher recombinant protein titers remains an ongoing challenge and a fundamental understanding of the cellular mechanism driving improved bioprocess performance remains ...
Kate E. Meeson   +9 more
wiley   +1 more source

Recommendations for sample selection, collection and preparation for NMR-based metabolomics studies of blood. [PDF]

open access: yesMetabolomics
Emwas AH   +29 more
europepmc   +1 more source

Microtiter Plate Cultivation Systems Enable Chemically Diverse Metabolic Footprints During Bacterial Natural Product Discovery

open access: yesBiotechnology and Bioengineering, EarlyView.
The utilization of microtiter plate cultivation systems in the discovery of natural products expands the secondary metabolic footprint. Microtiter plate cultivation systems, in particular the 48 well flower plate, facilitate the parallelization of bacterial cultivation and offer a greater degree of comparability to stirred tank bioreactors in ...
Anton Lindig   +2 more
wiley   +1 more source

A Comprehensive Model for Separating Systematic Bias and Noise in Metabolomic Timecourse Data—A Nonlinear B‐Spline Mixed‐Effects Approach

open access: yesBiotechnology and Bioengineering, EarlyView.
A nonlinear B‐spline mixed effects model for the simultaneous detection and correction of systematic error in timecourse metabolomics data. Systematic errors–such as those from dilution or incomplete extraction–affect all metabolites similarly and can be corrected by fitting all metabolites together in a single model.
Kathy Sharon Isaac, Stanislav Sokolenko
wiley   +1 more source

Mass spectrometry-based characterisation of the cardiac microtissue metabolome and lipidome. [PDF]

open access: yesMetabolomics
Bowen TJ   +7 more
europepmc   +1 more source

RSEA: A Web Server for Pathway Enrichment Analysis of Metabolic Reaction Sets

open access: yesBiotechnology and Bioengineering, EarlyView.
Reaction Set Enrichment Analysis (RSEA), a web server tool designed for metabolic pathway enrichment analysis of reaction sets derived from genome‐scale metabolic models was introduced. RSEA converts given reaction lists into standardized identifiers and statistically evaluates their enrichment across metabolic pathways.
Merve Yarıcı   +4 more
wiley   +1 more source

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