Results 301 to 310 of about 393,797 (377)

Lipid metabolism reprograming by SREBP1‐PCSK9 targeting sensitizes pancreatic cancer to immunochemotherapy

Cancer Communications, EarlyView.
Abstract Background Pancreatic cancer's aberrant lipid metabolism fuels cell growth, invasion, and metastasis, yet its impact on immune surveillance and immunotherapy is unclear. This study investigated how sterol regulatory element‐binding transcription factor 1 (SREBP1)‐driven lipid metabolism affects the tumor microenvironment (TME) in pancreatic ...
Mengyi Lao, Xiaozhen Zhang, Zejun Li, Kang Sun, Hanshen Yang, Sicheng Wang, Lihong He, Yan Chen, Hanjia Zhang, Jiatao Shi, Daqian Xu, Tingbo Liang, Xueli Bai   +12 more
wiley   +1 more source

Olive mill solid waste induces beneficial mushroom-specialized metabolite diversity revealed by computational metabolomics strategies. [PDF]

Metabolomics
Khatib S, Pereman I, Kostanda E, Zdouc MM, Ezov N, Schweitzer R, van der Hooft JJJ.   +6 more
europepmc   +1 more source

Phytochemicals in Cancer Therapy: A Structured Review of Mechanisms, Challenges, and Progress in Personalized Treatment

Chemistry &Biodiversity, Accepted Article.
Objective: Cancer remains a global health challenge, necessitating new therapeutic options. Phytochemicals, with diverse chemical structures and biological activities, show promise as anticancer agents. This review explores key phytochemicals, their mechanisms, and their potential integration into cancer therapy.
Alaa A. A. Aljabali, Mohammad A. Obeid, Rasha M. Bashatwah, Esam Qnais, Omar Gammoh, Abdelrahim Alqudah, Vijay Mishra, Yachana Mishra, Mohammad Ahmed Khan, Suhel Parvez, Mohamed El-Tanani, Taher Hatahet   +11 more
wiley   +1 more source

Staphylococcus aureus AgrA Modulators From South African Antimicrobial Plants

Chemistry &Biodiversity, EarlyView.
The study workflow utilized validated in silico [molecular docking, fingerprinting, pharmacokinetics prediction, molecular dynamics (MD) simulation, ligand‐protein contact maps] tools to bioprospect a wide variety of metabolites surveyed from South African plants with antimicrobial activities, and target them against the key S.
Christiana Eleojo Aruwa, Saheed Sabiu
wiley   +1 more source

MS1FA: Shiny app for the annotation of redundant features in untargeted metabolomics datasets. [PDF]

Bioinformatics
Shi R, Klawonn F, Brönstrup M, Franke R.   +3 more
europepmc   +1 more source

Detection of Fast Decliner of Diabetic Kidney Disease Using Chiral Amino Acid Profiling: A Pilot Study

Chemistry &Biodiversity, EarlyView.
We examined D‐amino acids in diabetic kidney disease (DKD). Among D‐amino acids, blood D‐serine was identified as a biomarker of DKD, and we found that short‐term change in blood D‐serine showed higher value in fast decliners in DKD patients, which meant the prognostic value of blood D‐serine in DKD.
Yosuke Hirakawa, Tomonori Kimura, Shinsuke Sakai, Masayuki Mizui, Masashi Mita, Yoshitaka Isaka, Masaomi Nangaku, Reiko Inagi   +7 more
wiley   +1 more source

1H nuclear magnetic resonance metabolomic analysis of mammary tumors from lean and obese Zucker rats exposed to 7,12-dimethylbenz[a]anthracene

, 2007
Tracy L. Whitehead, Andy Holley, Soheila Korourian, Saeid Shaaf, Thomas Kieber‐Emmons, Reza Hakkak   +5 more
openalex   +2 more sources

Mechanism Study on the Preventive Effect of ELITEA Compound Tea on Hyperuricemia in Rats Based on Serum Untargeted Metabolomics. [PDF]

Metabolites
Liu S, Zhu Y, Wang W, Zhang X, Gao L, Qiu X.   +5 more
europepmc   +1 more source

Ethnomedicinal Uses, Phytochemistry, Pharmacological Activities, and Toxicology of the Subfamily Gomphrenoideae (Amaranthaceae): A Comprehensive Review

Chemistry &Biodiversity, EarlyView.
ABSTRACT The subfamily Gomphrenoideae is composed of about 480 accepted species, many of which have been historically used as medicinal plants, reason why they have been studied in terms of chemical profile, biological activity, and safety. This review consolidates the advances in research on this subfamily over the past 47 years, emphasizing its ...
Dayanna Isabel Araque Gelves, Giulia Cristina de Andreoli Souza, Alvaro Jose Hernandez Tasco, Marcos José Salvador   +3 more
wiley   +1 more source

Dynamic single-cell metabolomics reveals cell-cell interaction between tumor cells and macrophages. [PDF]

Nat Commun
Zhang Y, Shi M, Li M, Qin S, Miao D, Bai Y.   +5 more
europepmc   +1 more source