Results 1 to 10 of about 63,134 (262)
Anti-metabotropic glutamate receptor 5 coexistent anti-N-methyl-D-aspartate receptor encephalitis: a case report and literature review [PDF]
Frontiers in ImmunologyMetabotropic glutamate receptor 5 (mGluR5) antibody encephalitis is an infrequent clinical disorder, initially reported in 2011 among two patients presenting with limbic encephalitis and Hodgkin’s lymphoma.
Yixin Gu +9 more
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Nature Communications, 2021 Here, the authors use smFRET to assess the structural dynamics of metabotropic glutamate receptor mGlu2 and show that a positive allosteric modulator or the Gi protein stabilize mGlu2 in the glutamate-induced active state, leading to the full activation ...
Anne-Marinette Cao +5 more
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Frontiers in Molecular Neuroscience, 2022 Members of the family of metabotropic glutamate receptors are involved in the pathomechanism of several disorders of the nervous system. Besides the well-investigated function of dysfunctional glutamate receptor signaling in neurodegenerative diseases ...
Teresa M. Lüffe +6 more
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Metabotropic glutamate receptors in cancer [PDF]
Neuropharmacology, 2017 Metabotropic glutamate receptors (mGluRs) are widely known for their roles in synaptic signaling. However, accumulating evidence suggests roles of mGluRs in human malignancies in addition to synaptic transmission. Somatic cell homeostasis presents intriguing possibilities of mGluRs and glutamate signaling as novel targets for human cancers.
Suzie Chen +3 more
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Brain gamma rhythm and potential treatment of neurodegenerative disease
Journal of Neurorestoratology, 2020 In this mini-review, we illustrate the brain network oscillations in different brain areas, including the medial septal diagonal band complex (MSDB) and hippocampus, especially at gamma frequency bands (γ, 30–80 Hz) and theta frequency bands (θ, 4–12 Hz),
Jianhua Zhao, Ailin Du, Chengbiao Lu
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Glutamatergic Mechanisms in Glioblastoma and Tumor-Associated Epilepsy
Cells, 2021 The progression of glioblastomas is associated with a variety of neurological impairments, such as tumor-related epileptic seizures. Seizures are not only a common comorbidity of glioblastoma but often an initial clinical symptom of this cancer entity ...
Falko Lange +2 more
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Metabotropic glutamate receptor trafficking [PDF]
Molecular and Cellular Neuroscience, 2018 The metabotropic glutamate receptors (mGlu receptors) are G protein-coupled receptors that bind to the excitatory neurotransmitter glutamate and are important in the modulation of neuronal excitability, synaptic transmission, and plasticity in the central nervous system.
Young Ho Suh +2 more
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L-Glutamate supplementation improves small intestinal architecture and enhances the expressions of jejunal mucosa amino acid receptors and transporters in weaning piglets. [PDF]
PLoS ONE, 2014 L-Glutamate is a major oxidative fuel for the small intestine. However, few studies have demonstrated the effect of L-glutamate on the intestinal architecture and signaling of amino acids in the small intestine.
Meng Lin +7 more
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Repurposing Fragile X Drugs to Inhibit SARS-CoV-2 Viral Reproduction
Frontiers in Cell and Developmental Biology, 2020 The COVID-19 pandemic is a global health crisis that requires the application of interdisciplinary research to address numerous knowledge gaps including molecular strategies to prevent viral reproduction in affected individuals.
Cara J. Westmark +6 more
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Cell Death and Disease, 2021 Glioblastoma (GBM), the most malignant tumor of the central nervous system, is marked by its dynamic response to microenvironmental niches. In particular, this cellular plasticity contributes to the development of an immediate resistance during tumor ...
Julian P. Maier +17 more
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