Results 1 to 10 of about 89,220 (264)

Neuronal metabotropic glutamate receptor 8 protects against neurodegeneration in CNS inflammation

Journal of Experimental Medicine, 2021
Systematic analysis of the neuronal receptor interactome in multiple sclerosis brains reveals the metabotropic glutamate receptor 8 as a disbalanced hub.
M. Woo, F. Ufer, Nicola Rothammer, Giovanni Di Liberto, Lars Binkle, U. Haferkamp, J. Sonner, J. B. Engler, S. Hornig, Simone Bauer, Ingrid Wagner, K. Egervari, J. Raber, R. Duvoisin, O. Pless, D. Merkler, M. Friese   +16 more
semanticscholar   +1 more source

Conformational rearrangement during activation of a metabotropic glutamate receptor

Nature Chemical Biology, 2020
G protein-coupled receptors (GPCRs) relay information across cell membranes through conformational coupling between the ligand-binding domain and cytoplasmic signaling domain.
B. Liauw, H. S. Afsari, Reza Vafabakhsh
semanticscholar   +1 more source

Metabotropic Glutamate Receptors As Emerging Targets for the Treatment of Schizophrenia

Molecular Pharmacology, 2022
Accumulating evidence of glutamatergic abnormalities in the brains of schizophrenia patients has led to efforts to target various components of glutamatergic signaling as potential new approaches for schizophrenia.
S. Dogra, P. Conn
semanticscholar   +1 more source

Metabotropic glutamate receptor subtype 2 is a cellular receptor for rabies virus

PLoS Pathogens, 2018
Rabies virus (RABV) invades the central nervous system and nearly always causes fatal disease in humans. How RABV interacts with host neuron membrane receptors to become internalized and cause rabid symptoms is not yet fully understood.
Jinliang Wang, Zilong Wang, Renqiang Liu, Lei Shuai, Xinxin Wang, Jie Luo, Chong Wang, Wei-ye Chen, Xi-jun Wang, Jin-ying Ge, Xijun He, Z. Wen, Z. Bu   +12 more
semanticscholar   +1 more source

Metabotropic glutamate receptor 5 knockout reduces cognitive impairment and pathogenesis in a mouse model of Alzheimer's disease

Molecular Brain, 2014
BackgroundAlzheimer’s disease (AD) pathology occurs in part as the result of excessive production of β-amyloid (Aβ). Metabotropic glutamate receptor 5 (mGluR5) is now considered a receptor for Aβ and consequently contributes to pathogenic Aβ signaling in
A. Hamilton, Jessica L Esseltine, Rebecca A Devries, S. Cregan, S. Ferguson   +4 more
semanticscholar   +1 more source

Metabotropic Glutamate Receptor-1 as a Novel Target for the Antiangiogenic Treatment of Breast Cancer

PLoS ONE, 2014
Metabotropic glutamate receptors (mGluRs) are normally expressed in the central nervous system, where they mediate neuronal excitability and neurotransmitter release.
C. Speyer, A. Hachem, Ali A. Assi, Jennifer Johnson, J. Devries, D. Gorski   +5 more
semanticscholar   +1 more source

Infrared Neural Stimulation Elicits Distinct Molecular Pathways in Astrocytes Based on Laser Pulse Parameters

Advanced Biology, EarlyView.
Infrared (IR) light evokes distinct calcium and water transport responses in astrocytes, depending on stimulation duration and protocol. This study uses widefield imaging and pharmacology to reveal differential engagement of astroglial signaling pathways.
Wilson R. Adams, Ana I Borrachero‐Conejo, Pratheepa Kumari Rasiah, Emanuella Saracino, Roberto Zamboni, Eric Duco Jansen, Valentina Benfenati, Anita Mahadevan‐Jansen   +7 more
wiley   +1 more source

The Memory-Enhancing Effects of Hippocampal Estrogen Receptor Activation Involve Metabotropic Glutamate Receptor Signaling

Journal of Neuroscience, 2013
Our laboratory has demonstrated that 17β-estradiol (E2) enhances hippocampal memory consolidation via rapid activation of multiple intracellular signaling cascades, including the ERK/MAPK cascade (Fernandez et al., 2008; Fan et al., 2010).
Marissa I. Boulware, J. Heisler, K. Frick   +2 more
semanticscholar   +1 more source

Advancements in DNA‐Driven Precision Modulation of Cell Surface Receptor for Programmable Cellular Functions

Advanced Science, EarlyView.
DNA‐Based Genetic and Non‐Genetic Tools for Receptor Engineering. This review highlights recent advances in DNA‐based strategies for receptor engineering, including genetic approaches like domain fusion and site‐directed mutagenesis, as well as non‐genetic methods using functional nucleic acids, DNA nanostructures, and dynamic DNA reactions.
Hexin Nan, Ming Cai, Yiyu Wang, Hong‐Hui Wang, Zhou Nie   +4 more
wiley   +1 more source

Neuro‐Cancer Interactions Shape Glioma Intratumoral Heterogeneity

Advanced Science, EarlyView.
This review proposes a conceptual framework for understanding glioma intratumoral heterogeneity shaped by neuro‐cancer interactions: functional patterns and transcriptional states. Functional patterns manifest as three major neural‐like adaptations with spatial and potentially hierarchical relationships, including neurogliomal synapses, glioma networks,
Tong Wu, Peiran Zhao, Zheng Chen, Tianlei Ying, Zhihong Nie, Wei Hua, Huiyan Li, Ying Mao, Wenbo Bu   +8 more
wiley   +1 more source