Journal of Neurochemistry, Volume 169, Issue 6, June 2025.Autism spectrum disorder (ASD) is a neurodevelopmental condition linked to glutamatergic neurotransmission abnormalities. We analyzed by HPLC the cerebral and peripheral profiles of D‐aspartate, D‐serine, and other L‐amino acids involved in NMDA receptor signaling in environmental ASD rat models prenatally exposed to lipopolysaccharide or valproate ...
Anna Di Maio +9 more
wiley +1 more source
Metabotropic Glutamate Receptors and Epileptiform Bursting
Epilepsy Currents, 2002 Differential Roles for mGluR1 and mGluR5 in the Persistent Prolongation of Epileptiform Bursts Merlin LR J Neurophysiol 2002;87:621–625 Purpose Transient activation of group I metabotropic glutamate receptors (mGluRs) with the selective agonist (S)-3,5-dihydroxyphenylglycine (DHPG) produces persistent prolongation of epileptiform bursts in guinea ...
openaire +3 more sources
Experimental Physiology, Volume 110, Issue 6, Page 888-898, 1 June 2025.Abstract The sex hormones progesterone (P) and oestrogen (E) reorganize GABAergic transmission in the prefrontal cortex (PFC) during the transition from childhood to adolescence, generating a new excitatory–inhibitory balance necessary for the computational capacity of the mature PFC.
Aitana Vázquez‐Sola +2 more
wiley +1 more source
Repeated \u3cem\u3eN\u3c/em\u3e-Acetylcysteine Administration Alters Plasticity-Dependent Effects of Cocaine [PDF]
, 2007 Cocaine produces a persistent reduction in cystine–glutamate exchange via system xc− in the nucleus accumbens that may contribute to pathological glutamate signaling linked to addiction.
Abdulhameed, Omer +7 more
core +1 more source
The Enteric Neuronal Circuitry: A Key Ignored Player in Nutrient Sensing Along the Gut–Brain Axis
The FASEB Journal, Volume 39, Issue 9, 15 May 2025.The enteric nervous system (ENS) regulates critical physiological functions including gut motility, blood flow, and epithelial secretions. Despite its autonomous ability to execute local functions, its communication with the central nervous system is integral to the maintenance of homeostasis.
Ester Nikolla +4 more
wiley +1 more source
Distinct beta-arrestin coupling and intracellular trafficking of metabotropic glutamate receptor homo- and heterodimers. [PDF]
Sci Adv, 2023 Lee J +8 more
europepmc +1 more source
Metabotropic glutamate receptor 1 alpha: a unique receptor variant with variable implications for Alzheimer's disease pathogenesis. [PDF]
Neural Regen Res, 2023 Yeung JH, Kwakowsky A.
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Sleep problems in old age: metabotropic glutamate receptor to the rescue. [PDF]
Sleep, 2023 Inami S, Afonso DJS, Koh K.
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Concerted conformational changes control metabotropic glutamate receptor activity. [PDF]
Sci Adv, 2023 Lecat-Guillet N +12 more
europepmc +1 more source
Plasma endocannabinoids in cocaine dependence and their relation to cerebral metabotropic glutamate receptor 5 density. [PDF]
Transl Psychiatry, 2023 Kroll SL +12 more
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