Buried Treasure? Overlooked and Newly Discovered Evolutionary Contributions to Human Brain Diseases
Annals of Neurology, Volume 98, Issue 6, Page 1178-1195, December 2025.[Color figure can be viewed at www.annalsofneurology.org] Recapitulative schema of different exploratory levels of the evolutionary impact on human neurological diseases. Clinical neuroscience focuses on the mechanisms of brain function, but this approach falls short of insights into how the central nervous system (CNS) evolved, both in health and ...
Nico J. Diederich +20 more
wiley +1 more source
Frontiers in Molecular Neuroscience, 2016 NMDA receptors are Ca2+-permeable ion channels. The activation of NMDA receptors requires agonist glutamate and co-agonist glycine. Recent evidence indicates that NMDA receptor also has metabotropic function.
Li-Jun Li +15 more
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Journal of Biological Chemistry, 2011 Shank3/PROSAP2 gene mutations are associated with cognitive impairment ranging from mental retardation to autism. Shank3 is a large scaffold postsynaptic density protein implicated in dendritic spines and synapse formation; however, its specific ...
C. Verpelli +11 more
semanticscholar +1 more source
Brain and Behavior, Volume 15, Issue 12, December 2025.ABSTRACT Introduction Chronic stress can have significant impacts on both physical and mental health, including affecting learning and memory processes. Research has shown that exposure to stress during prenatal and neonatal stages can have long‐lasting effects on individuals. The objective of this study is to investigate how prenatal stress influences
Manijeh Dogani +2 more
wiley +1 more source
Type-1 metabotropic glutamate receptor signaling in cerebellar Purkinje cells in health and disease [PDF]
, 2017 Masanobu Kano, Takaki Watanabe
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Metabotropic Glutamate Receptors in Glial Cells: A New Potential Target for Neuroprotection?
Frontiers in Molecular Neuroscience, 2018 Neurodegenerative disorders are characterized by excitotoxicity and neuroinflammation that finally lead to slow neuronal degeneration and death. Although neurons are the principal target, glial cells are important players as they contribute by either ...
S. Spampinato +4 more
semanticscholar +1 more source
Metabotropic glutamate receptors: Phosphorylation and receptor signaling
Journal of Neuroscience Research, 2007 AbstractMetabotropic glutamate receptors (mGluRs) play important roles in neurotransmission, neuronal development, synaptic plasticity, and neurological disorders. Recent studies have revealed a sophisticated interplay between mGluRs and protein kinases: activation of mGluRs regulates the activity of a number of kinases, and direct phosphorylation of ...
Chul Hoon, Kim +3 more
openaire +3 more sources
Exocytosis of Vesicular Zinc Reveals Persistent Depression of Neurotransmitter Release during Metabotropic Glutamate Receptor Long-Term Depression at the Hippocampal CA3–CA1 Synapse [PDF]
, 2006 Jing Qian, Jeffrey L. Noebels
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Metabotropic glutamate receptor 5: a target for migraine therapy
Annals of Clinical and Translational Neurology, 2016 Introduction Many patients suffering from migraine gain little relief from existing treatments partly because many existing acute and preventive therapies used in migraine have been adopted from other neurologic conditions such as depression or epilepsy.
Maggie W. Waung +4 more
doaj +1 more source
Reduction of Glutamatergic Neurotransmission by Prolonged Exposure to Dieldrin Involves NMDA Receptor Internalization and Metabotropic Glutamate Receptor 5 Downregulation [PDF]
, 2009 Víctor Briz +2 more
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