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The Structures of Metabotropic Glutamate Receptors [PDF]
, 2008 Interest in the structures of the metabotropic glutamate receptors continues to increase for a variety of reasons, including the fact that they are now established drug targets and are linked to a wide spectrum of physiologic processes both within and outside the central nervous system.
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Metabotropic Glutamate Receptors and Neuronal Toxicity
1992Specific glutamate receptors coupled to polyphosphoinositide (PPI) hydrolysis have been described in brain slices, cultured neurons, and astrocytes, and in amphibian oocytes injected with rat brain mRNA (Sladeczek et al., 1985; Nicoletti et al., 1986a,b; Sugiyama et al., 1987).
ALEPPO G +7 more
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The metabotropic glutamate receptors of the vestibular organs
Hearing Research, 1998This research sought to test the presence and function of metabotropic excitatory amino acid receptors (mGluR) in the frog semicircular canal (SCC). The mGluR agonist +/- 1-aminocyclopentane-trans-1,3-dicarboxylate (ACPD) produced an increase in afferent firing rates of the ampullar nerve of the intact posterior canal.
Paola Perin +9 more
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Effects of bromohomoibotenate on metabotropic glutamate receptors
NeuroReport, 1994(S)-Bromohomoibotenic acid [(S)-BrHIbo] stereoselectively antagonized glutamate-stimulated phosphoinositide (PI) hydrolysis in baby hamster kidney (BHK) cells expressing mGluR1a in a competitive manner with an IC50 of 250 microM. However, (S)-BrHIbo did not inhibit (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid [(1S,3R)-ACPD]-induced PI hydrolysis ...
Peter D. Suzdak +5 more
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Metabotropic Glutamate Receptors: Gatekeepers of Homeostasis
Journal of Neuroendocrinology, 2010The capacity to appropriately respond to physiological challenges or perturbations in homeostasis is a requisite for survival. It is becoming increasingly clear that long‐lasting alterations in synaptic efficacy are a fundamental mechanism for modifying neuroendocrine and autonomic output. We review recent advances in our understanding of plasticity at
Jaideep S. Bains, J. B. Kuzmiski
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The metabotropic glutamate receptors: Structure and functions
Neuropharmacology, 1995Glutamate is the main excitatory neurotransmitter in the brain. For many years it has been considered to act only on ligand-gated receptor channels--termed NMDA, AMPA and kainate receptors--involved in the fast excitatory synaptic transmission. Recently, glutamate has been shown to regulate ion channels and enzymes producing second messengers via ...
Jean-Philippe Pin, Robert M. Duvoisin
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Modulation of Excitation by Metabotropic Glutamate Receptors
2007Metabotropic glutamate receptors, in contrast to ionotropic glutamate receptors, do not form ion channels but instead affect intracellular chemical messenger systems. They couple via GTP-binding proteins ("G-proteins") to a variety of effectors such as ion channels and thus give glutamate, the major excitatory transmitter in the CNS, the ability to ...
Marylka Uusisaari, Thomas Knöpfel
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PHARMACOLOGY AND FUNCTIONS OF METABOTROPIC GLUTAMATE RECEPTORS
Annual Review of Pharmacology and Toxicology, 1997▪ Abstract In the mid to late 1980s, studies were published that provided the first evidence for the existence of glutamate receptors that are not ligand-gated cation channels but are coupled to effector systems through GTP-binding proteins. Since those initial reports, tremendous progress has been made in characterizing these metabotropic glutamate ...
Pin Jp, Conn Pj
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Get receptive to metabotropic glutamate receptors
Current Opinion in Neurobiology, 1995Glutamate activates not only ionotropic glutamate receptors, but also G-protein-coupled receptors, called metabotropic glutamate receptors. Recent studies have revealed that these metabotropic receptors share distinctive structural properties and that they form a subgroup within the heptahelical receptor family.
Jean-Philippe Pin, Joël Bockaert
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Coordinate regulation of metabotropic glutamate receptors
Current Opinion in Neurobiology, 2001Recent studies aimed at identifying the mechanisms that regulate the signaling of metabotropic glutamate receptors (mGluRs) have revealed that both protein kinase and protein phosphatase activity are important in directly modulating mGluR function. The inter-relationship between phosphorylation and dephosphorylation of mGluRs seems to be an important ...
Scott D. Sorensen +2 more
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