Results 201 to 210 of about 89,220 (264)

Metabotropic glutamate receptors and epilepsy

Journal of the Neurological Sciences, 2006
Metabotropic glutamate receptors (mGluRs) play an important role in the initiation of ictal discharges by participating in the interictal-ictal transition, and may play a crucial role in recruiting normal brain tissue into synchronized discharges, thereby facilitating propagation of seizure activity.
Michel Baudry, Mónica Perassolo, Jorge A. Ure   +2 more
openaire   +3 more sources

Sequence and expression of a metabotropic glutamate receptor

Nature, 1991
The complementary DNA of a metabotropic glutamate receptor coupled to inositol phosphate/Ca2+ signal transduction has been cloned and characterized. This receptor shows no sequence similarity to conventional G protein-coupled receptors and has a unique structure with large hydrophilic sequences at both sides of seven putative membrane-spanning domains.
M. Masu, Y. Tanabe, K. Tsuchida, R. Shigemoto, S. Nakanishi   +4 more
semanticscholar   +4 more sources

International Union of Basic and Clinical Pharmacology. CXI. Pharmacology, Signaling, and Physiology of Metabotropic Glutamate Receptors

Pharmacological Reviews, 2020
Metabotropic glutamate (mGlu) receptors respond to glutamate, the major excitatory neurotransmitter in the mammalian brain, mediating a modulatory role that is critical for higher-order brain functions such as learning and memory.
K. Gregory, C. Goudet
semanticscholar   +1 more source

Metabotropic Glutamate Receptors in Glial Cells

Neurochemical Research, 2008
Glutamate is the major excitatory neurotransmitter in the mammalian central nervous system (CNS) and exerts its actions via a number of ionotropic glutamate receptors/channels and metabotropic glutamate (mGlu) receptors. In addition to being expressed in neurons, glutamate receptors are expressed in different types of glial cells including astrocytes ...
Simona D'Antoni, Antonio Berretta, Carmela Maria Bonaccorso, BRUNO, Valeria Maria Gloria, Eleonora Aronica, NICOLETTI, Ferdinando, Maria Vincenza Catania   +6 more
openaire   +6 more sources

Metabotropic glutamate receptors, 5 years on

Neuropharmacology, 2017
[no abstract]
Collingridge, Graham L., Manahan Vaughan, Denise, NICOLETTI, Ferdinando, Schoepp, Darryle D.   +3 more
openaire   +4 more sources

Metabotropic Glutamate Receptors as Drug Targets

Current Drug Targets, 2007
L-glutamate (Glu), the main excitatory amino acid neurotransmitter in the mammalian central nervous system, is involved in many physiological functions, including learning and memory, but also in toxic phenomena occurring in numerous degenerative or neurological diseases.
Récasens, Max, Guiramand, Janique, Aimar, Rose, Abdulkarim, Ahmad, Barbanel, Gérard   +4 more
openaire   +3 more sources

Dynamics and modulation of metabotropic glutamate receptors

Current Opinion in Pharmacology, 2015
The metabotropic glutamate receptors (mGluRs) are glutamate-activated G protein-coupled receptors widely expressed in the central nervous system. The eight mGluRs subtypes modulate transmission at many synapses, and are interesting therapeutic targets for the treatment of many neurological and psychiatric diseases.
Jean-Philippe Pin, Philippe Rondard, Philippe Rondard, Philippe Rondard   +3 more
openaire   +3 more sources

Metabotropic receptors for glutamate and GABA in pain

Brain Research Reviews, 2009
Glutamate and gamma-amino butyric acid (GABA) are respectively two major excitatory and inhibitory neurotransmitters of the adult mammalian central nervous system. These neurotransmitters exert their action through two types of receptors: ionotropic and metabotropic receptors.
Cyril Goudet, Frédéric Nagy, Frédéric Nagy, Jean-Philippe Pin, Jean-Philippe Pin, Marc Landry, Marc Landry, Valerio Magnaghi, Robert W. Gereau   +8 more
openaire   +3 more sources

Immunohistochemical visualization of a metabotropic glutamate receptor

NeuroReport, 1993
The immunocytochemical localization of the recently cloned metabotropic glutamate receptor 1 alpha (mGluR1 alpha) was demonstrated with a C-terminus specific antibody in rat cerebellar cortex. This antibody detects a 138-140 kDa major, and a 46 kDa minor band in membrane preparations of rat cortex and cerebellum.
Görcs Tamás Jenő, Penke Botond, Bőti Zsuzsanna, Katarova Zója, Hámori József   +4 more
openaire   +3 more sources

Metabotropic Glutamate Receptors and Neuronal Toxicity

1992
Specific glutamate receptors coupled to polyphosphoinositide (PPI) hydrolysis have been described in brain slices, cultured neurons, and astrocytes, and in amphibian oocytes injected with rat brain mRNA (Sladeczek et al., 1985; Nicoletti et al., 1986a,b; Sugiyama et al., 1987).
ALEPPO G, PISANI A, COPANI A, BRUNO V, ARONICA E, D'AGATA V, CANONICO P. L, NICOLETTI F   +7 more
openaire   +6 more sources