Results 31 to 40 of about 89,220 (264)

Central Amygdala Metabotropic Glutamate Receptor 5 in the Modulation of Visceral Pain

Journal of Neuroscience, 2012
Painful bladder syndrome is a debilitating condition that affects 3–6% of women in the United States. Multiple lines of evidence suggest that changes in CNS processing are key to the development of chronic bladder pain conditions but little is known ...
Lara W. Crock, B. Kolber, Clinton D Morgan, K. Sadler, S. Vogt, M. Bruchas, R. Gereau   +6 more
semanticscholar   +1 more source

Exploring the pathophysiology underlying clozapine‐induced enhancement of glutamatergic transmission through L‐glutamate and D‐serine release associated with pannexin1 hemichannels

British Journal of Pharmacology, EarlyView.
Abstract Background and purpose Clozapine, an approved antipsychotic for treatment‐resistant schizophrenia (TRS), enhances glutamatergic transmission by increasing exocytosis and non‐exocytosis glutamate release; however, its full action remained to be clarified.
Motohiro Okada, Ruri Okubo, Eishi Motomura   +2 more
wiley   +1 more source

Clioquinol as a new therapy in epilepsy: From preclinical evidence to a proof‐of‐concept clinical study

Epilepsia, EarlyView.
Abstract Objective Drug‐resistant epilepsy (DRE) affects >25 million people worldwide and is often associated with neuroinflammation. Increasing evidence links deficiency or malfunctioning of the enzyme phosphoglycerate dehydrogenase (PHGDH), which converts 3‐phosphoglycerate to generate serine and the neurotransmitter glycine, with (drug‐resistant ...
Karin Thevissen, Annelii Ny, Daniëlle Copmans, Jana Tits, Kenichi Kamata, Eva Gielis, Kevin Longin, Jo Sourbron, Peravina Thergarajan, Tracie Huey‐Lin Tan, Idrish Ali, Nigel C. Jones, Terence J. O'Brien, Mastura Monif, Bridgette D. Semple, Christine Germeys, Benedetta Frizzi, Virginia Minniti, Sebastian Perrone, Carole L. Linster, Ilaria Elia, Ludo Van Den Bosch, Bruno P. A. Cammue, Arnout Voet, Lieven Lagae, Peter de Witte   +25 more
wiley   +1 more source

WONOEP XVII appraisal: Targeting network excitability beyond the synapse ‐Neurotransmitter, ionic, and electro ‐diffusions

Epilepsia, EarlyView.
Abstract Epilepsy affects approximately 1% of the population worldwide, and although medications are effective in the majority of cases, seizures persist in approximately 30% of patients. Despite the effort to develop new antiseizure drugs, the rate of pharmacoresistance in patients has not diminished over the past 3 decades. There is thus a real unmet
Vincent Magloire, Marco de Curtis, Jeffrey Noebels, Gilles Huberfeld, Piotr Suffczynski, Vadym Gnatkovsky, Olga Tyurikova, Dominique Durand, David C. Henshall, Cian McCafferty   +9 more
wiley   +1 more source

Lower density of calretinin‐immunopositive neurons in the putamen of subjects with schizophrenia

Journal of Anatomy, Volume 246, Issue 4, Page 505-516, April 2025.
Recent neuroimaging and histological studies highlight the striatum as a key area involved in SCH, but the specific impairment of neuronal subtypes in subcortical structures is not fully understood. This study is the first detailed investigation of neuroanatomical changes in the putamen in SCH, specifically examining the density of calretinin ...
Paz Kelmer, Paulina Hoppa, Erzsébet Frank, Teadora Tyler, Istvan Adorjan   +4 more
wiley   +1 more source

G-protein activation by a metabotropic glutamate receptor

Nature, 2021
A. B. Seven, X. Barros-Álvarez, Marine de Lapeyrière, M. Papasergi-Scott, M. J. Robertson, Chensong Zhang, Robert M Nwokonko, Yang Gao, J. Meyerowitz, J. Rocher, Dominik W. Schelshorn, B. Kobilka, J. M. Mathiesen, G. Skiniotis   +13 more
semanticscholar   +1 more source

Adaptations to hypoxia in the vertebrate retina

The Journal of Physiology, EarlyView.
Abstract figure legend Most animals, including mammals, are susceptible to the damaging effects of hypoxia or ischaemia, where the result is neuronal cell death in the brain. By contrast, some neurons of the mammalian retina are less sensitive to hypoxia. In both brain and retina, neurons may survive if first preconditioned with ischaemia.
Michael G. Jonz
wiley   +1 more source

Group 1 Metabotropic Glutamate Receptor Function and Its Regulation of Learning and Memory in the Aging Brain

Frontiers in Pharmacology, 2012
Normal aging is generally characterized by a slow decline of cognitive abilities albeit with marked individual differences. Several animal models have been studied to explore the molecular and cellular mechanisms underlying this phenomenon.
C. Ménard, R. Quirion
semanticscholar   +1 more source

The mysterious middlemen making your vision pop: understanding the function of amacrine cells

The Journal of Physiology, EarlyView.
Abstract figure legend This review aims to illustrate the diversity and function of amacrine cells in the retina. The diversity of amacrine cell subtypes is depicted based on morphology, stratification and neurotransmitter expression, along with their synaptic connectivity with bipolar and ganglion cells, emphasizing inhibitory and modulatory roles ...
Victor Calbiague‐Garcia, Deborah Varro, Thomas Buffet, Olivier Marre   +3 more
wiley   +1 more source

Metabotropic glutamate receptors in auditory processing [PDF]

Neuroscience, 2014
As the major excitatory neurotransmitter used in the vertebrate brain, glutamate activates ionotropic and metabotropic glutamate receptors (mGluRs), which mediate fast and slow neuronal actions, respectively. Important modulatory roles of mGluRs have been shown in many brain areas, and drugs targeting mGluRs have been developed for the treatment of ...
openaire   +3 more sources