Metabotropic glutamate 2/3 receptors and epigenetic modifications in psychotic disorders: a review [PDF]
Schizophrenia and Bipolar Disorder are chronic psychiatric disorders, both considered as "major psychosis"; they are thought to share some pathogenetic factors involving a dysfunctional gene x environment interaction.
Grayson, Danis R+4 more
core +2 more sources
Synergistic inhibition of survival, proliferation, and migration of U87 cells with a combination of LY341495 and Iressa. [PDF]
Glioblastomas exploit various molecular pathways to promote glutamate- dependent growth by activating the AMPA (2-amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl) propanoic acid) receptor, the group II metabotropic glutamate receptor, mGluR, and the epidermal ...
Zarina Yelskaya+5 more
doaj +1 more source
Targeting mGlu5 metabotropic glutamate receptors in the treatment of cognitive dysfunction in a mouse model of phenylketonuria [PDF]
We studied group-I metabotropic glutamate (mGlu) receptors in Pah(enu2) (ENU2) mice, which mimic the genetics and neurobiology of human phenylketonuria (PKU), a metabolic disorder characterized, if untreated, by autism, and intellectual disability (ID ...
Battaglia, Giuseppe+12 more
core +2 more sources
Anti-metabotropic glutamate receptor 1 encephalitis is an uncommon autoimmune condition characterized by a subacute onset of cerebellar syndrome. Frequently, it also manifests as sleep disorders and cognitive or behavioral changes. While immunotherapy is
Xue Chen+6 more
doaj +1 more source
Orthogonal Activation of Metabotropic Glutamate Receptor Using Coordination Chemogenetics
Cell-surface receptors play a pivotal role as transducers of extracellular input. Although different cell types express the same receptor, the physiological roles of the receptor are highly dependent on cell type.
Akinobu Senoo+7 more
doaj +1 more source
Metabotropic Receptors for Glutamate and GABA [PDF]
G protein-coupled receptors (GPCRs) are the largest superfamily of transmembrane proteins and due to their ubiquitous expression and vast array of functions they present attractive targets for the treatment of a wide number of diseases and disorders.
Laurent Prézeau+5 more
openaire +3 more sources
Sequences within the C terminus of the metabotropic glutamate receptor 5 (mGluR5) are responsible for inner nuclear membrane localization [PDF]
Traditionally, G-protein-coupled receptors (GPCR) are thought to be located on the cell surface where they transmit extracellular signals to the cytoplasm.
Harmon, Steven K.+4 more
core +2 more sources
Our previous studies have shown that glutamate and hippocampal neuron apoptosis are key signals and direct factors associated with diabetes-related depression, and structural and functional damage to the hippocampal neurovascular unit has been associated
Jian Liu+7 more
doaj +1 more source
Permissive role for mGlu1 metabotropic glutamate receptors in excitotoxic retinal degeneration [PDF]
Neuroprotection is an unmet need in eye disorders characterized by retinal ganglion cell (RGC) death, such as prematurity-induced retinal degeneration, glaucoma, and age-related macular degeneration.
Battaglia, Giuseppe+10 more
core +1 more source
Bidirectional Control of Synaptic GABAAR Clustering by Glutamate and Calcium
GABAergic synaptic transmission regulates brain function by establishing the appropriate excitation-inhibition (E/I) balance in neural circuits.
Hiroko Bannai+9 more
doaj +1 more source