Metabotropic Glutamate Receptors and Epileptogenesis
Epilepsy Currents, 2002 Activation of metabotropic glutamate receptors (mGluRs) often produces long-lasting effects on the excitability of cortical neurons. For example, mGluR stimulation induces long-term potentiation or depression of excitatory synaptic transmission in the hippocampus.
Robert K. S. Wong +2 more
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ASN Neuro, 2009 A number of studies suggest that OLGs (oligodendrocytes), the myelinating cells of the central nervous system, are also a source of trophic molecules, such as neurotrophins that may influence survival of proximate neurons.
Issa P Bagayogo, Cheryl F Dreyfus
doaj +1 more source
FMRP mediates mGluR5-dependent translation of amyloid precursor protein. [PDF]
PLoS Biology, 2007 Amyloid precursor protein (APP) facilitates synapse formation in the developing brain, while beta-amyloid (Abeta) accumulation, which is associated with Alzheimer disease, results in synaptic loss and impaired neurotransmission.
Cara J Westmark, James S Malter
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Analgesia induced by the epigenetic drug, L-acetylcarnitine, outlasts the end of treatment in mouse models of chronic inflammatory and neuropathic pain [PDF]
, 2017 Background: L-acetylcarnitine, a drug marketed for the treatment of chronic pain, causes analgesia by epigenetically up-regulating type-2 metabotropic glutamate (mGlu2) receptors in the spinal cord.
Battaglia, Giuseppe +10 more
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Causative Factors for ADHD: Role of Copy Number Variants in ADHD
Pediatric Neurology Briefs, 2014 Investigators from Brazil determined if copy number variants (CNVs) in glutamate metabotropic receptor genes (GRM) were overrepresented in 1038 individuals with ADHD compared to 1057 subjects without ADHD.
J Gordon Millichap, John J Millichap
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Glutamate, GABA and acetylcholine signaling components in the lamina of the Drosophila visual system. [PDF]
PLoS ONE, 2008 Synaptic connections of neurons in the Drosophila lamina, the most peripheral synaptic region of the visual system, have been comprehensively described.
Agata Kolodziejczyk +3 more
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Modeling T1 Resting-State MRI Variants Using Convolutional Neural Networks in Diagnosis of OCD [PDF]
arXiv, 2023 Obsessive-compulsive disorder (OCD) presents itself as a highly debilitating disorder. The disorder has common associations with the prefrontal cortex and the glutamate receptor known as Metabotropic Glutamate Receptor 5 (mGluR5). This receptor has been observed to demonstrate higher levels of signaling from positron emission tomography scans measured ...
arxiv
Increased accuracy of ligand sensing by receptor diffusion on cell surface [PDF]
Physical Review E 82, 041902 (2010), 2010 The physical limit with which a cell senses external ligand concentration corresponds to the perfect absorber, where all ligand particles are absorbed and overcounting of same ligand particles does not occur. Here we analyze how the lateral diffusion of receptors on the cell membrane affects the accuracy of sensing ligand concentration.
arxiv +1 more source
Neuronal activity patterns in the mediodorsal thalamus and related cognitive circuits are modulated by metabotropic glutamate receptors. [PDF]
, 2015 The mediodorsal thalamus (MD) likely plays an important role in cognition as it receives abundant afferent connections from the amygdala and prefrontal cortex (PFC).
Copeland, CS, Neale, SA, Salt, TE
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Permissive role for mGlu1 metabotropic glutamate receptors in excitotoxic retinal degeneration [PDF]
, 2017 Neuroprotection is an unmet need in eye disorders characterized by retinal ganglion cell (RGC) death, such as prematurity-induced retinal degeneration, glaucoma, and age-related macular degeneration.
Battaglia, Giuseppe +10 more
core +1 more source