Results 71 to 80 of about 26,303 (100)
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Metabotropic glutamate receptors and epilepsy
Journal of the Neurological Sciences, 2006Metabotropic glutamate receptors (mGluRs) play an important role in the initiation of ictal discharges by participating in the interictal-ictal transition, and may play a crucial role in recruiting normal brain tissue into synchronized discharges, thereby facilitating propagation of seizure activity.
Michel Baudry +2 more
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Metabotropic Glutamate Receptors in Glial Cells
Neurochemical Research, 2008Glutamate is the major excitatory neurotransmitter in the mammalian central nervous system (CNS) and exerts its actions via a number of ionotropic glutamate receptors/channels and metabotropic glutamate (mGlu) receptors. In addition to being expressed in neurons, glutamate receptors are expressed in different types of glial cells including astrocytes ...
Simona D'Antoni +6 more
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Metabotropic Glutamate Receptors as Drug Targets
Current Drug Targets, 2007L-glutamate (Glu), the main excitatory amino acid neurotransmitter in the mammalian central nervous system, is involved in many physiological functions, including learning and memory, but also in toxic phenomena occurring in numerous degenerative or neurological diseases.
Récasens, Max +4 more
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Dynamics and modulation of metabotropic glutamate receptors
Current Opinion in Pharmacology, 2015The metabotropic glutamate receptors (mGluRs) are glutamate-activated G protein-coupled receptors widely expressed in the central nervous system. The eight mGluRs subtypes modulate transmission at many synapses, and are interesting therapeutic targets for the treatment of many neurological and psychiatric diseases.
Jean-Philippe Pin +3 more
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Metabotropic glutamate receptors, 5 years on
Neuropharmacology, 2017[no abstract]
Collingridge, Graham L. +3 more
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Metabotropic receptors for glutamate and GABA in pain
Brain Research Reviews, 2009Glutamate and gamma-amino butyric acid (GABA) are respectively two major excitatory and inhibitory neurotransmitters of the adult mammalian central nervous system. These neurotransmitters exert their action through two types of receptors: ionotropic and metabotropic receptors.
Cyril Goudet +8 more
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Immunohistochemical visualization of a metabotropic glutamate receptor
NeuroReport, 1993The immunocytochemical localization of the recently cloned metabotropic glutamate receptor 1 alpha (mGluR1 alpha) was demonstrated with a C-terminus specific antibody in rat cerebellar cortex. This antibody detects a 138-140 kDa major, and a 46 kDa minor band in membrane preparations of rat cortex and cerebellum.
Görcs Tamás Jenő +4 more
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2008 Eruptions in metabotropic glutamate receptors
Neuropharmacology, 2008[No abstract available]
NICOLETTI, Ferdinando +2 more
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The Structures of Metabotropic Glutamate Receptors [PDF]
, 2008 Interest in the structures of the metabotropic glutamate receptors continues to increase for a variety of reasons, including the fact that they are now established drug targets and are linked to a wide spectrum of physiologic processes both within and outside the central nervous system.
Erin M. Rose +2 more
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Metabotropic Glutamate Receptors and Neuronal Toxicity
1992Specific glutamate receptors coupled to polyphosphoinositide (PPI) hydrolysis have been described in brain slices, cultured neurons, and astrocytes, and in amphibian oocytes injected with rat brain mRNA (Sladeczek et al., 1985; Nicoletti et al., 1986a,b; Sugiyama et al., 1987).
ALEPPO G +7 more
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