Results 71 to 80 of about 62,813 (331)

Anti-mGluR1 encephalitis: Case illustration and systematic review

Frontiers in Neurology, 2023
BackgroundThe literature for immune-mediated neurological disorders is evolving like no other field of neurological illnesses. Many new antibodies or disorders have been described in the last decade.
Osama Khojah, Osama Khojah, Osama Khojah, Seraj Makkawi, Seraj Makkawi, Seraj Makkawi, Saeed Alghamdi   +6 more
doaj   +1 more source

Estimating the synaptic current in a multi-conductance AMPA receptor model [PDF]

, 2010
A pre-synaptic neuron releases diffusing neurotransmitters such as glutamate that activate post-synaptic receptors. The amplitude of the post-synaptic current, mostly mediated by glutamatergic (AMPARs) receptors, is a fundamental signal that may generate an action potential.
arxiv   +1 more source

Metabotropic glutamate receptors: Phosphorylation and receptor signaling

Journal of Neuroscience Research, 2007
AbstractMetabotropic glutamate receptors (mGluRs) play important roles in neurotransmission, neuronal development, synaptic plasticity, and neurological disorders. Recent studies have revealed a sophisticated interplay between mGluRs and protein kinases: activation of mGluRs regulates the activity of a number of kinases, and direct phosphorylation of ...
Jinu Lee, Katherine W. Roche, Jae-Youn Lee, Chul Hoon Kim   +3 more
openaire   +3 more sources

Membrane Topology of a Metabotropic Glutamate Receptor [PDF]

Journal of Biological Chemistry, 2003
The metabotropic glutamate receptors (mGluRs) have been predicted to have a classical seven transmembrane domain structure similar to that seen for members of the G-protein-coupled receptor (GPCR) superfamily. However, the mGluRs (and other members of the family C GPCRs) show no sequence homology to the rhodopsin-like GPCRs, for which this seven ...
Ruchir D. Shah, D. J. Brasier, Stephen F. Heinemann, Gautam Bhave, Kathi S. Glauner, Robert W. Gereau, Brian M. Nadin, Farzana Karim   +7 more
openaire   +3 more sources

Unraveling Neurodevelopment: Synergistic Effects of Intrinsic Genetic Programs and Extrinsic Environmental Cues

Advanced Science, EarlyView.
Overview of the regulation of intrinsic and extrinsic signals during neurodevelopment. Intrinsic genetic signals from NSCs, in conjunction with cues from microglia and blood vessels, collaboratively regulate the proliferation of NSCs, their fate determination, synaptogenesis, synaptic pruning, neuronal survival, and death, as well as communication ...
Yanyan Wang, Shukui Zhang, Huiyang Jia, Fen Ji, Jianwei Jiao   +4 more
wiley   +1 more source

Quantifying constraints determining independent activation on NMDA receptors mediated currents from evoked and spontaneous synaptic transmission at an individual synapse [PDF]

arXiv, 2022
A synapse acts on neural transmission through a chemical process called synapses fusion between pre-synaptic and post-synaptic terminals. Presynaptic terminals release neurotransmitters either in response to action potential or spontaneously independent of presynaptic activity.
arxiv  

Shedding Light on Metabotropic Glutamate Receptors [PDF]

Cell Chemical Biology, 2016
In this issue of Cell Chemical Biology, the elegant manuscript by Rovira et al. (2016) describes a negative allosteric modulator (NAM) of mGlu4 metabotropic glutamate receptors with in vivo activity. This compound is rapidly and reversibly inactivated by light and represents a powerful pharmacological tool for the study of mGlu4 receptors in their ...
openaire   +3 more sources

Chromosome‐Level Genome Assembly of the Leafcutter Bee Megachile rotundata Reveals Its Ecological Adaptation and Pollination Biology

Advanced Science, EarlyView.
The genome of Megachile rotundata, an extensively managed solitary pollination bee species, has been sequenced, covering 280.68 Mb and predicting 10 701 genes. The study reveals significant expansions of the Toll gene family and their abundant expression in diapause prepupae, highlighting enhanced immune responses during diapause. This genome serves as
Rangjun Shi, Pan Duan, Mengmeng Zhu, Rong Zhang, Zihua Zhao, Xin Nie, Hanhou He, Li Hou, Xianhui Wang   +8 more
wiley   +1 more source

The Selective Metabotropic Glutamate 2/3 Receptor Agonist MGS0028 Reverses Isolation Rearing–Induced Abnormal Behaviors in Mice

Journal of Pharmacological Sciences, 2012
Isolation-induced abnormal behaviors are useful animal models for assessing potential anti-psychotic drugs. This study examined the effect of MGS0028, a selective metabotropic glutamate 2/3 receptor agonist, on abnormal behaviors such as hyperactivity ...
Yukio Ago, Ryota Araki, Koji Yano, Toshiyuki Kawasaki, Shigeyuki Chaki, Atsuro Nakazato, Hirotaka Onoe, Hitoshi Hashimoto, Akemichi Baba, Kazuhiro Takuma, Toshio Matsuda   +10 more
doaj  

The Lateral Metalation of Isoxazolo[3,4-d]pyridazinones towards Hit-to-Lead Development of Selective Positive Modulators of Metabotropic Glutamate Receptors

Molecules, 2023
Isoxazolo[3,4-d] pyridazinones ([3,4-d]s) were previously shown to have selective positive modulation at the metabotropic glutamate receptor (mGluR) Subtypes 2 and 4, with no functional cross-reactivity at mGluR1a, mGluR5, or mGluR8.
Christina A. Gates, Donald S. Backos, Philip Reigan, Nicholas R. Natale   +3 more
doaj   +1 more source