British Journal of Pharmacology, Volume 182, Issue 15, Page 3612-3627, August 2025.Abstract Background and Purpose Several G protein‐coupled receptors (GPCRs) are known to homodimerise. Dimeric GPCRs may have different properties from their monomers, but the molecular basis and functional significance of GPCR dimerisation remain largely unknown.
Satoshi Asano +6 more
wiley +1 more source
Stimulatory effects of the putative metabotropic glutamate receptor antagonist L‐AP3 on phosphoinositide turnover in neonatal rat cerebral cortex [PDF]
, 1996 Rajendra Mistry +3 more
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CNS Neuroscience &Therapeutics, Volume 31, Issue 8, August 2025.Our findings suggest that functional connections of the preSMA are disrupted in PSA patients, which may be associated with neurotransmitter activity, possibly serving as the predictive markers for recovery of PSA. ABSTRACT Background The pre‐supplementary motor area (preSMA) is a critical region within domain‐general networks involved in speech ...
Daoran Wang +11 more
wiley +1 more source
Inhibition of long-term potentiation in the dentate gyrus of freely moving rats by the metabotropic glutamate receptor antagonist MCPG [PDF]
, 1995 Gernot Riedel, G. Casabona, KG Reymann
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European Journal of Neuroscience, Volume 62, Issue 3, August 2025.McGeachan et al. demonstrate microgliosis, astrogliosis and increased synaptic engulfment by microglia and astrocytes in regions with Aβ plaques in aged cat brains and cats with cognitive dysfunction syndrome (CDS). Microglia and astrocytes also show enhanced internalisation of amyloid‐beta‐containing synapses near plaques.
Robert I. McGeachan +11 more
wiley +1 more source
Efgartigimod as a Fast‐Acting Add‐On Therapy in Antibody–Mediated Autoimmune Encephalitis
European Journal of Neurology, Volume 32, Issue 8, August 2025.ABSTRACT Background Autoimmune encephalitis (AE) is a severe neurological disorder that requires effective and safe treatment options. This study aimed to compare the efficacy and safety of intravenous methylprednisolone (IVMP) plus efgartigimod (IPE) versus IVMP alone or IVMP plus immunoglobulin (IPI) as initial treatments for antibody‐mediated AE ...
Zhuajin Bi +4 more
wiley +1 more source
Multiple presynaptic metabotropic glutamate receptors modulate excitatory and inhibitory synaptic transmission in hippocampal area CA1 [PDF]
, 1995 RW Gereau, P. Jeffrey Conn
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Altered metabotropic glutamate receptor 5 markers in PTSD: In vivo and postmortem evidence
Proceedings of the National Academy of Sciences of the United States of America, 2017 Sophie E. Holmes +11 more
semanticscholar +1 more source
European Journal of Neurology, Volume 32, Issue 8, August 2025.This monocentric observational study investigates a fixed combination of acetyl‐L‐carnitine, palmitoylethanolamide, and alpha‐lipoic acid in 48 patients with acute low back pain. Over 8 weeks, treatment led to significant reductions in neuropathic pain scores, decreased NSAID consumption, and improvements in quality of life, supporting its potential ...
Mattia Cominacini +5 more
wiley +1 more source
Molecular, functional, and pharmacological characterization of the metabotropic glutamate receptor type 5 splice variants: comparison with mGluR1 [PDF]
, 1995 C. Joly +5 more
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