Results 131 to 140 of about 52,074 (275)

Temporal Profiling of Male Cortical Astrocyte Transcription Predicts Molecular Shifts From Early Development to Aging

Glia, Volume 73, Issue 7, Page 1349-1364, July 2025.
Main Points Comprehensive analysis of cortical astrocyte gene expression across the lifespan. Profiling dynamic changes of key astrocyte genes reveals functional shifts. Astrocytes contribute to gene‐length‐dependent transcription decline in the aging brain.
Xiaoran Wei, Jiangtao Li, Michelle L. Olsen   +2 more
wiley   +1 more source

Design, Synthesis, and Characterization of [¹⁸F]mG2P026 as a High-Contrast PET Imaging Ligand for Metabotropic Glutamate Receptor 2. [PDF]

J Med Chem, 2022
Yuan G, Dhaynaut M, Guehl NJ, Afshar S, Huynh D, Moon SH, Iyengar SM, Jain MK, Pickett JE, Kang HJ, Ondrechen MJ, El Fakhri G, Normandin MD, Brownell AL.   +13 more
europepmc   +1 more source

Role of P/Q-Ca²⁺ Channels in Metabotropic Glutamate Receptor 2/3-Dependent Presynaptic Long-Term Depression at Nucleus Accumbens Synapses [PDF]

, 2002
David Robbe, Gérard Alonso, Séverine Chaumont‐Dubel, Joël Bockaert, Olivier J. Manzoni   +4 more
openalex   +1 more source

Stimulation of microglial metabotropic glutamate receptor mGlu2 triggers tumor necrosis factor alpha-induced neurotoxicity in concert with microglial-derived fas ligand [PDF]

, 2005
Activated microglia may be detrimental to neuronal survival in a number of neurodegenerative diseases. Thus, strategies that reduce microglial neurotoxicity may have therapeutic benefit.
Jones, F, Kubota, ESFCS, Pocock, JM, Taylor, DL   +3 more
core  

Multi‐Omic Analysis Reveals Astrocytic Annexin‐A2 as Critical for Network‐Level Circadian Timekeeping in the Suprachiasmatic Nucleus

Glia, Volume 73, Issue 7, Page 1483-1501, July 2025.
Main Points Multi‐omics reveal Annexin‐A2 (A2) and S100a10 (A10) as SCN astrocyte enriched proteins. Disrupting A2‐A10 complex elevates astrocyte Ca2+ and compromises SCN timekeeping. Astrocytic A2‐A10 is a critical control point for SCN network rhythms.
Andrew P. Patton, Toke P. Krogager, Elizabeth S. Maywood, Nicola J. Smyllie, Emma L. Morris, Mark Skehel, Michael H. Hastings   +6 more
wiley   +1 more source

Metabotropic Glutamate Receptor 5 Upregulation in A-Fibers after Spinal Nerve Injury: 2-Methyl-6-(Phenylethynyl)-Pyridine (MPEP) Reverses the Induced Thermal Hyperalgesia [PDF]

, 2002
Lindsey Hudson, Stuart Bevan, Kara McNair, Clive Gentry, Alyson Fox, Rainer Kühn, Janet Winter   +6 more
openalex   +1 more source

Understanding the Intersection Between Hormonal Dynamics and Brain Plasticity in Alzheimer's Disease: A Narrative Review for Implementing New Therapeutic Strategies

Health Science Reports, Volume 8, Issue 7, July 2025.
ABSTRACT Background and Aims Alzheimer's disease (AD), a chronic neurodegenerative disorder, is portrayed by neurocognitive decline in the structure and function of the human brain. Various factors are implicated in the pathogenesis to neuroplasticity alteration in the brain of an individual afflicted with AD.
Abir Ghosson, Fatima Soufan, Hussein Kaddoura, Elissa Fares, Olivier Uwishema   +4 more
wiley   +1 more source

Synthesis and Characterization of [¹⁸F]JNJ-46356479 as the First ¹⁸F-Labeled PET Imaging Ligand for Metabotropic Glutamate Receptor 2. [PDF]

Mol Imaging Biol, 2021
Yuan G, Guehl NJ, Zheng B, Qu X, Moon SH, Dhaynaut M, Shoup TM, Afshar S, Kang HJ, Zhang Z, El Fakhri G, Normandin MD, Brownell AL.   +12 more
europepmc   +1 more source

Metabotropic Glutamate 2 Receptors Modulate Synaptic Inputs and Calcium Signals in Striatal Cholinergic Interneurons [PDF]

, 2002
Antonio Pisani, Paola Bonsi, Maria Vincenza Catania, Rosario Giuffrida, Michele Morari, Matteo Marti, Diego Centonze, Giorgio Bernardi, Ann E. Kingston, Paolo Calabresi   +9 more
openalex   +1 more source

Glutamine Metabolism: Molecular Regulation, Biological Functions, and Diseases

MedComm, Volume 6, Issue 7, July 2025.
Tumor cells adapt to nutrient‐poor environments by altering metabolism to acquire essential nutrients. They convert glutamine into glutamate and α‐ketoglutarate, supporting mTOR activation and sugar biosynthesis. Disruption of mTORC1 signaling is linked to disease, while glutamine and leucine activation promotes cell growth and inhibits autophagy ...
Mudasir A. Kumar, Sana Khurshid Baba, Inamu Rashid Khan, Mohd Shahnawaz Khan, Fohad Mabood Husain, Saheem Ahmad, Mohammad Haris, Mayank Singh, Ammira S. Al‐Shabeeb Akil, Muzafar A. Macha, Ajaz A. Bhat   +10 more
wiley   +1 more source