Results 141 to 150 of about 52,074 (275)

Experience-dependent plasticity without long-term depression by type 2 metabotropic glutamate receptors in developing visual cortex [PDF]

, 2002
John J. Renger, Kenichi N. Hartman, Yoshiko Tsuchimoto, Mineto Yokoi, Shigetada Nakanishi, Takao K. Hensch   +5 more
openalex   +1 more source

Chronic cocaine enhances release of neuroprotective amino acid taurine: a microdialysis study [PDF]

, 2008
Cocaine inhibits high-affinity neurotransmitter uptake at the presynaptic nerve terminals to increase synaptic levels of dopamine, norepinephrine and serotonin^1^. This increase of synaptic dopamine may cause neurotoxicity^2,3^.
Eitan Freedman, Elena Yablonski-Alter, Eleonora Gashi, Mervan Agovic, Shailesh Banerjee, Theodore Lidsky   +5 more
core   +1 more source

Light‐Activated Pharmacological Tools for Exploring the Cholinergic System

Medicinal Research Reviews, Volume 45, Issue 4, Page 1251-1274, July 2025.
ABSTRACT Cholinergic transmission plays a critical role in both the central and peripheral nervous systems, affecting processes such as learning, memory, and inflammation. Conventional cholinergic drugs generally suffer from poor selectivity and temporal precision, leading to undesired effects and limited therapeutic efficacy. Photopharmacology aims to
Alessio Colleoni, Giulia Galli, Clelia Dallanoce, Marco De Amici, Pau Gorostiza, Carlo Matera   +5 more
wiley   +1 more source

Metabotropic Glutamate Receptor Activation Enhances the Activities of Two Types of Ca²⁺-Activated K⁺Channels in Rat Hippocampal Astrocytes [PDF]

, 2003
Debebe Gebremedhin, Ken Yamaura, Chenyang Zhang, Johan Bylund, Raymond C. Koehler, David R. Harder   +5 more
openalex   +1 more source

A proteomic study to unveil lead toxicity-induced memory impairments invoked by synaptic dysregulation

Toxicology Reports, 2022
Lead (Pb2+), a ubiquitously present heavy metal toxin, has various detrimental effects on memory and cognition. However, the molecular processes affected by Pb2+ causing structural and functional anomalies are still unclear.
Nivedha Mohanraj, Neha S. Joshi, Roshni Poulose, Rahul R. Patil, Rashmi Santhoshkumar, Anubhav Kumar, Girish P. Waghmare, Amit Kumar Saha, Syeda Zehra Haider, Yogananda S. Markandeya, Gourav Dey, Laxmi T. Rao, Periyasamy Govindaraj, Bhupesh Mehta   +13 more
doaj  

Synthesis and Characterization of 5-(2-Fluoro-4-[¹¹C]methoxyphenyl)-2,2-dimethyl-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide as a PET Imaging Ligand for Metabotropic Glutamate Receptor 2. [PDF]

J Med Chem, 2022
Yuan G, Dhaynaut M, Lan Y, Guehl NJ, Huynh D, Iyengar SM, Afshar S, Jain MK, Pickett JE, Kang HJ, Wang H, Moon SH, Ondrechen MJ, Wang C, Shoup TM, El Fakhri G, Normandin MD, Brownell AL.   +17 more
europepmc   +1 more source

Therapeutic Targeting of the α7 Nicotinic Receptor: Challenges and Prospects for Cognitive Improvement in Alzheimer's and Schizophrenia [PDF]

Basic Clin Pharmacol Toxicol
ABSTRACT The α7 nicotinic acetylcholine receptor (α7 nAChR) has emerged as a key target for treating cognitive dysfunction in neurological disorders such as Alzheimer's disease (AD) and schizophrenia. α7 nAChRs play essential roles in neurotransmission, neuroinflammation and synaptic plasticity, not only in neurons but also in glial cells, where they ...
Magnussen J.
europepmc   +2 more sources

Two Intracellular Pathways Mediate Metabotropic Glutamate Receptor-Induced Ca²⁺Mobilization in Dopamine Neurons [PDF]

, 2003
Hitoshi Morikawa, Kamran Khodakhah, John T. Williams   +2 more
openalex   +1 more source

Could MDMA Promote Stemness Characteristics in Mouse Embryonic Stem Cells via mGlu5 Metabotropic Glutamate Receptors? [PDF]

Cell Journal, 2012
Objective: Ecstasy, or 3, 4 (±) methylenedioxymethamphetamine (MDMA), is a potent neurotoxic drug. One of the mechanisms for its toxicity is the secondary release of glutamate.
Rokhsareh Meamar, Fereshte Karamali, Seyed Ali Mousavi, Hossein Baharvand, Mohammad Hossein Nasr-Esfahani   +4 more
doaj  

Liquiritigenin‐Rich Hydroalcoholic Extract of Brazilian Red Propolis Reduces Dyskinesia Induced by 3,4‐ Dihydroxyphenylalanine in Hemiparkinsonian Rats

Basic &Clinical Pharmacology &Toxicology, Volume 137, Issue 1, July 2025.
ABSTRACT The set‐up and progression of dyskinesia induced by 3,4‐dihydroxyphenylalanine (L‐DOPA) are strongly linked to oxidative stress and neuroinflammation. The aim of this work was to study and characterize the effects of the hydroalcoholic extract of Brazilian red propolis (HERP) on L‐DOPA–induced dyskinesia (LID) in hemiparkinsonian rats injected
Sheilla da Silva Barroso, Lorenna E. S. Lopes, Ana M. G. dos Santos, Reinaldo V. B. Neto, Bruno dos Santos Lima, Adriano A. de Souza Araújo, Juliana C. Cardoso, Patricia Severino, Eliana B. Souto, Margarete Z. Gomes   +9 more
wiley   +1 more source