Results 1 to 10 of about 75,386 (292)

Dissociation of impulsive traits by subthalamic metabotropic glutamate receptor 4 [PDF]

eLife, 2022
Behavioral strategies require gating of premature responses to optimize outcomes. Several brain areas control impulsive actions, but the neuronal basis of natural variation in impulsivity between individuals remains largely unknown.
Lukasz Piszczek, Andreea Constantinescu, Dominic Kargl, Jelena Lazovic, Anton Pekcec, Janet R Nicholson, Wulf Haubensak   +6 more
doaj   +5 more sources

Expression of metabotropic glutamate receptor 4 in osteosarcoma. [PDF]

Mol Clin Oncol, 2016
Metabotropic glutamate receptor 4 (mGluR4) has been associated with the pathogenesis of osteosarcoma. The aim of this study was to investigate mGluR4 expression and its clinical significance in osteosarcoma patients.
Wang S, Wei X, Chen B, Zhao M, Song G, Zhang Z, Li N.   +6 more
europepmc   +7 more sources

Glial metabotropic glutamate receptor-4 increases maturation and survival of oligodendrocytes [PDF]

Frontiers in Cellular Neuroscience, 2015
Group III metabotropic glutamate (mGlu) receptors mediate important neuroprotective and anti-inflammatory effects. Stimulation of mGlu4 receptor reduces neuroinflammation in a mouse model of experimental autoimmune encephalomyelitis (EAE) whereas mGlu4 ...
Simona Federica Spampinato, Sara eMerlo, Mariangela eChisari, Ferdinando eNicoletti, Ferdinando eNicoletti, Maria Angela eSortino   +5 more
doaj   +6 more sources

Targeting metabotropic glutamate receptor 4 for cancer immunotherapy. [PDF]

Sci Adv, 2021
Immune cell–derived GRM4 negatively modulates antitumor immune response.
Wan Z, Sun R, Liu YW, Li S, Sun J, Li J, Zhu J, Moharil P, Zhang B, Ren P, Ren G, Zhang M, Ma X, Dai S, Yang D, Lu B, Li S.   +16 more
europepmc   +5 more sources

A nanobody activating metabotropic glutamate receptor 4 discriminates between homo- and heterodimers. [PDF]

Proc Natl Acad Sci U S A, 2021
Significance Biologics, and especially antibodies, are promising therapeutics. Antibodies are expected to show higher subtype selectivity and less off-target activity than small molecules.
Haubrich J, Font J, Quast RB, Goupil-Lamy A, Scholler P, Nevoltris D, Acher F, Chames P, Rondard P, Prézeau L, Pin JP.   +10 more
europepmc   +6 more sources

Photoswitchable positive allosteric modulators of metabotropic glutamate receptor 4 to improve selectivity [PDF]

iScience
Summary: Metabotropic glutamate receptors (mGlu) regulate multiple functions in the nervous systems and are involved in several neurological disorders.
Silvia Panarello, Aleix González-Díez, Alice E. Berizzi, Fanny Malhaire, Roser Borràs-Tudurí, Xavier Rovira, Carme Serra, Laurent Prézeau, Jean-Philippe Pin, Cyril Goudet, Amadeu Llebaria, Xavier Gómez-Santacana   +11 more
doaj   +5 more sources

Activity of Metabotropic Glutamate Receptor 4 Suppresses Proliferation and Promotes Apoptosis With Inhibition of Gli-1 in Human Glioblastoma Cells [PDF]

Frontiers in Neuroscience, 2018
Glioblastoma multiforme (GBM) is the most lethal glioma variant in the adult brain and among the deadliest of human cancers. Increasing evidence has shown that metabotropic glutamate receptor subtype 4 (mGluR4) expression may play roles in regulating the
Zhichao Zhang, Zhichao Zhang, Xiaoyan Zheng, Yan Luan, Yingfei Liu, Xingxing Li, Chongxiao Liu, Chongxiao Liu, Haixia Lu, Xinlin Chen, Xinlin Chen, Yong Liu   +11 more
doaj   +3 more sources

Aquaporin 4-Mediated Glutamate-Induced Astrocyte Swelling Is Partially Mediated through Metabotropic Glutamate Receptor 5 Activation

Frontiers in Cellular Neuroscience, 2017
Astrocytes are one of the most abundant cell types in the mammalian central nervous system (CNS), and astrocyte swelling is the primary event associated with brain edema.
Fang Yuan, Fang Yuan, Fang Yuan, Fang Yuan, Fang Yuan, Zhongfang Shi, Zhongfang Shi, Zhongfang Shi, Zhongfang Shi, Zhongfang Shi, Wei Zhang, Wei Zhang, Wei Zhang, Wei Zhang, Wei Zhang, Yang Lu, Yang Lu, Yang Lu, Yang Lu, Yang Lu, Yi Lu, Yi Lu, Yi Lu, Yi Lu, Yi Lu, Lixin Xu, Lixin Xu, Lixin Xu, Lixin Xu, Lixin Xu, Qing Fang, Qing Fang, Qing Fang, Qing Fang, Qing Fang, Min Wu, Min Wu, Min Wu, Min Wu, Min Wu, Mei Jia, Mei Jia, Mei Jia, Mei Jia, Mei Jia, Yujiao Wang, Yujiao Wang, Yujiao Wang, Yujiao Wang, Yujiao Wang, Liping Dong, Liping Dong, Liping Dong, Liping Dong, Liping Dong, Xu Yan, Xu Yan, Xu Yan, Xu Yan, Xu Yan, Shaohua Yang, Shaohua Yang, Shaohua Yang, Shaohua Yang, Shaohua Yang, Shaohua Yang   +65 more
doaj   +4 more sources

Critical role of metabotropic glutamate receptor 4 in bone marrow-derived dendritic cells in the Th17 cell differentiation and the melanogenesis of B16 cells [PDF]

Brazilian Journal of Medical and Biological Research, 2020
Vitiligo is an acquired pigmentary disorder resulting from selective destruction of melanocytes. Emerging studies have suggested that T helper cell 17 (Th17) is potentially implicated in vitiligo development and progression.
Guangming Zhao, Wenhui Zhou, Ying Liu, Yupeng Wang, Zhou Li, Zhiqi Song   +5 more
doaj   +2 more sources

Metabotropic glutamate receptor 4-mediated glutamatergic signaling reshapes the tumor microenvironment by regulating dendritic cell maturation [PDF]

Nature Communications
Metabotropic glutamate receptor 4 (mGluR4, encoded by Grm4), is a neurotransmitter receptor, known to play roles in tumor progression and immune modulation through the nervous system.
Xiaoman Ju, Eva Maria Putz, Yaqi Liu, Dongchen Yuan, Guowei Sun, Stephane Koda, Zhuo Fu, Simin Shao, Chunrong Tong, Biping Deng, Jing Hu, Juming Yan   +11 more
doaj   +2 more sources