Results 41 to 50 of about 50,881 (191)

Orofacial antinociceptive activity and anchorage molecular mechanism in silico of geraniol [PDF]

Brazilian Oral Research, 2020
We aimed to evaluate the orofacial antinociceptive effect of geraniol in mice and its molecular anchorage mechanism. Seven mice per group (probabilistic sample) were treated with geraniol (12.5, 25 and 50 mg/kg, i.p.), morphine (6 mg/kg, i.p.) and ...
Tereza Karla Vieira Lopes da COSTA, Mariana Silva BARROS, Renan Marrinho BRAGA, Jéssika de Oliveira VIANA, Frederico Barbosa de SOUSA, Luciana SCOTTI, Marcus Tullius SCOTTI, André Ulisses Dantas BATISTA, Reinaldo Nóbrega de ALMEIDA, Ricardo Dias de CASTRO   +9 more
doaj   +1 more source

Glutamate Receptor Dysregulation in the Hippocampus of Transgenic Mice Carrying Mutated Human Amyloid Precursor Protein

Neurobiology of Disease, 2001
Alzheimer's disease transgenic mice overexpressing human amyloid precursor protein (hAPP) with the Swedish double mutation (hAPPSw) develop age-related amyloid deposition and behavioral and electrophysiologic changes by an unknown mechanism.
Jang-Ho J. Cha, Laurie A. Farrell, Sharlin F. Ahmed, Ariel Frey, Karen K. Hsiao-Ashe, Anne B. Young, John B. Penney, Joseph J. Locascio, Bradley T. Hyman, Michael C. Irizarry   +9 more
doaj   +1 more source

The role of mGlu4 receptors within the nucleus accumbens in acquisition and expression of morphine-induced conditioned place preference in male rats

BMC Neuroscience, 2021
Background Several studies have shown that glutamate neurotransmission in the nucleus accumbens (NAc) is required for the development of morphine-induced conditional place preference (CPP).
Zahra Ebrahimi, Nazanin Kahvandi, Alireza Komaki, Seyed Asaad Karimi, Marzieh Naderishahab, Abdolrahman Sarihi   +5 more
doaj   +1 more source

Silent Allosteric Modulation of mGluR5 Maintains Glutamate Signaling while Rescuing Alzheimer’s Mouse Phenotypes

Cell Reports, 2017
Metabotropic glutamate receptor 5 (mGluR5) has been implicated in Alzheimer’s disease (AD) pathology. We sought to understand whether mGluR5’s role in AD requires glutamate signaling.
Laura T. Haas, Santiago V. Salazar, Levi M. Smith, Helen R. Zhao, Timothy O. Cox, Charlotte S. Herber, Andrew P. Degnan, Anand Balakrishnan, John E. Macor, Charles F. Albright, Stephen M. Strittmatter   +10 more
doaj   +1 more source

Long-term activation of group I metabotropic glutamate receptors increases functional TRPV1-expressing neurons in mouse dorsal root ganglia

Frontiers in Cellular Neuroscience, 2016
Damaged tissues release glutamate and other chemical mediators for several hours. These chemical mediators contribute to modulation of pruritus and pain.
Takayoshi eMasuoka, Makiko eKudo, Junko eYoshida, Takaharu eIshibashi, Takaharu eIshibashi, Ikunobu eMuramatsu, Nobuo eKato, Noriko eImaizumi, Matomo eNishio   +8 more
doaj   +1 more source

Curcumin Protects against Monosodium Glutamate Neurotoxicity and Decreasing NMDA2B and mGluR5 Expression in Rat Hippocampus

Neurosignals, 2016
Background: Monosodium glutamate (MSG) is a flavor enhancer used in food industries. MSG is well documented to induce neurotoxicity. Curcumin (CUR) reportedly possesses beneficial effects against various neurotoxic insults.
Rania M. Khalil, Naglaa F. Khedr
doaj   +1 more source

First evidence for the presence of amino acid sensing mechanisms in the fish gastrointestinal tract

Scientific Reports, 2021
This study aimed to characterize amino acid sensing systems in the gastrointestinal tract (GIT) of the carnivorous fish model species rainbow trout. We observed that the trout GIT expresses mRNAs encoding some amino acid receptors described in mammals ...
Jessica Calo, Ayelén M. Blanco, Sara Comesaña, Marta Conde-Sieira, Sofia Morais, José L. Soengas   +5 more
doaj   +1 more source

A Randomized, Double‐Blind, Controlled Phase II Study of Foliglurax in Parkinson's Disease

Movement Disorders, 2022
Agents targeting the metabotropic glutamate receptor 4 have emerged as a potentially attractive new class of drugs for the treatment of Parkinson's disease (PD).
O. Rascol, R. Medori, C. Baayen, P. Such, D. Meulien   +4 more
semanticscholar   +1 more source

Structural basis of the activation of metabotropic glutamate receptor 3

Cell Research, 2022
Dear Editor, Glutamate is used by most synapses in the brain and responsible for fast excitatory transmission, thus playing impor- tant roles in excitotoxicity and ammonium detoxi fi cation in the brain.
W. Fang, Fan Yang, Chanjuan Xu, S. Ling, Li Lin, Yingxin Zhou, Wenjing Sun, Xiaomei Wang, Peng Liu, P. Rondard, P. Shi, J. Pin, C. Tian, Jianfeng Liu   +13 more
semanticscholar   +1 more source

Antipsychotic profiles of TASP0443294, a novel and orally active positive allosteric modulator of metabotropic glutamate 2 receptor

Journal of Pharmacological Sciences, 2015
Glutamatergic dysfunction has been implicated in psychiatric disorders such as schizophrenia. The stimulation of metabotropic glutamate (mGlu) 2 receptor has been shown to be effective in a number of animal models of schizophrenia.
Hirohiko Hikichi, Tetsuaki Hiyoshi, Toshiyuki Marumo, Yasumitsu Tomishima, Ayaka Kaku, Izumi Iida, Hiroki Urabe, Tomoko Tamita, Akito Yasuhara, Jun-ichi Karasawa, Shigeyuki Chaki   +10 more
doaj   +1 more source