Results 61 to 70 of about 75,386 (292)
Functional and Pharmacological Characteristics of Metabotropic Glutamate Receptors 2/4 Heterodimers [PDF]
Molecular Pharmacology, 2012 Metabotropic glutamate receptors (mGluRs) were thought until recently to function mainly as stable homodimers, but recent work suggests that heteromerization is possible. Despite the growth in available compounds targeting mGluRs, little is known about the pharmacological profile of mGluR heterodimers. Here, this question was addressed for the mGluR2/4
openaire +2 more sources
NMDA Receptor-Dependent Metaplasticity by High-Frequency Magnetic Stimulation
Neural Plasticity, 2014 High-frequency magnetic stimulation (HFMS) can elicit N-methyl-D-aspartate (NMDA) receptor-dependent long-term potentiation (LTP) at Schaffer collateral-CA1 pyramidal cell synapses.
Tursonjan Tokay +4 more
doaj +1 more source
Frontiers in Neurology, 2014 Antiglutamatergic drugs can relieve Parkinson’s disease (PD) symptoms and decrease L-3,4-dihydroxyphenylalanine (L-DOPA)-induced dyskinesias (LID).
Nicolas eMorin +3 more
doaj +1 more source
Anticonvulsive effect of paeoniflorin on experimental febrile seizures in immature rats: possible application for febrile seizures in children. [PDF]
PLoS ONE, 2012 Febrile seizures (FS) is the most common convulsive disorder in children, but there have been no clinical and experimental studies of the possible treatment of FS with herbal medicines, which are widely used in Asian countries.
Hitomi Hino +5 more
doaj +1 more source
Orofacial antinociceptive activity and anchorage molecular mechanism in silico of geraniol [PDF]
Brazilian Oral Research, 2020 We aimed to evaluate the orofacial antinociceptive effect of geraniol in mice and its molecular anchorage mechanism. Seven mice per group (probabilistic sample) were treated with geraniol (12.5, 25 and 50 mg/kg, i.p.), morphine (6 mg/kg, i.p.) and ...
Tereza Karla Vieira Lopes da COSTA +9 more
doaj +1 more source
Neurobiology of Disease, 2001 Alzheimer's disease transgenic mice overexpressing human amyloid precursor protein (hAPP) with the Swedish double mutation (hAPPSw) develop age-related amyloid deposition and behavioral and electrophysiologic changes by an unknown mechanism.
Jang-Ho J. Cha +9 more
doaj +1 more source
A population of immature cerebellar parallel fibre synapses are insensitive to adenosine but are inhibited by hypoxia [PDF]
, 2011 The purine adenosine plays an important role in a number of physiological and pathological processes and is neuroprotective during hypoxia and ischemia.
Atterbury, Alison, Wall, Mark J.
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BMC Neuroscience, 2021 Background Several studies have shown that glutamate neurotransmission in the nucleus accumbens (NAc) is required for the development of morphine-induced conditional place preference (CPP).
Zahra Ebrahimi +5 more
doaj +1 more source
Nanoscale Mapping of the Subcellular Glycosylation Landscape
Advanced Science, EarlyView.Using multiplexed super‐resolution imaging with fluorophore‐labeled lectins, this study reports intracellular glycosylation at the nanoscale across organelles and synaptic specializations. Extending glycan analysis beyond the cell surface, Glyco‐STORM reveals distinct glycosylation nanodomains in the ER, Golgi, lysosomes, and synaptic sites.
Helene Gregoria Schroeter +4 more
wiley +1 more source
Permissive role for mGlu1 metabotropic glutamate receptors in excitotoxic retinal degeneration [PDF]
, 2017 Neuroprotection is an unmet need in eye disorders characterized by retinal ganglion cell (RGC) death, such as prematurity-induced retinal degeneration, glaucoma, and age-related macular degeneration.
Battaglia, Giuseppe +10 more
core +1 more source