Results 61 to 70 of about 51,164 (271)
Ophelia syndrome with metabotropic glutamate receptor 5 antibodies in CSF [PDF]
Neurology, 2013 A 35-year-old man developed progressive memory problems and personality changes over the course of 6 months. This amnesia culminated in overt functional impairment as he began getting lost in familiar places and paid his rent multiple times in one day. He then displayed increased aggression and was admitted to hospital after assaulting a family member.
Giuseppe Gullo +6 more
openaire +3 more sources
Advanced Science, EarlyView.A cost‐effective strategy is developed analyzing sub‐threshold GWAS loci (5 × 10−8 < P ≤ 10−6), identifying 180 risk loci and 304 high‐confidence genes through combined GWAS/subGWAS analysis. This approach reveals dendrite development and morphogenesis (DDM) as a novel SCZ pathway.
Rui Chen +15 more
wiley +1 more source
Norbin Is an Endogenous Regulator of Metabotropic Glutamate Receptor 5 Signaling [PDF]
Science, 2009 Norbin Knockout Metabotropic glutamate receptors (mGluRs) are critical neurotransmitter sensors implicated in central neuronal functions like learning and memory and in diseases of the nervous system. Wang et al. (p.
Marc Flajolet +10 more
openaire +3 more sources
Structural Basis of GABAB Receptor Activation during Evolution
Advanced Science, EarlyView.This study explores the structural and functional mechanisms of the drosophila GABAB receptor, a key role in neurotransmission. Using cryo‐EM, the research reveals how the receptor's activation differs from its human counterpart, highlighting unique evolutionary features.
Guofei Hou +14 more
wiley +1 more source
NMDA Receptor-Dependent Metaplasticity by High-Frequency Magnetic Stimulation
Neural Plasticity, 2014 High-frequency magnetic stimulation (HFMS) can elicit N-methyl-D-aspartate (NMDA) receptor-dependent long-term potentiation (LTP) at Schaffer collateral-CA1 pyramidal cell synapses.
Tursonjan Tokay +4 more
doaj +1 more source
Antinociceptive actions of honokiol and magnolol on glutamatergic and inflammatory pain
Journal of Biomedical Science, 2009 The antinociceptive effects of honokiol and magnolol, two major bioactive constituents of the bark of Magnolia officinalis, were investigated on animal paw licking responses and thermal hyperalgesia induced by glutamate receptor agonists including ...
Ko Chien-Hsin +4 more
doaj +1 more source
Molecular Neurobiology, 2016 Glutamate is one of the major excitatory neurotransmitters of the CNS and is essential for numerous key neuronal functions. However, excess glutamate causes massive neuronal death and brain damage owing to excitotoxicity via the glutamate receptors ...
Chunjie Li +8 more
semanticscholar +1 more source
Genome‐Wide Insights and Polygenic Risk Scores in Common Epilepsies: A Narrative Review
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.ABSTRACT The research of single gene‐related disorders or pathogenic copy‐number variations (CNVs) has given a significant impetus to the shift from a diagnostic work‐up focused on epileptic syndromes to genomic approaches in individuals with severe pediatric‐onset epilepsies and in developmental and epileptic encephalopathies.
Mario Mastrangelo +5 more
wiley +1 more source
Functional metabotropic glutamate receptors 1 and 5 are expressed in murine podocytes [PDF]
Kidney International, 2012 In non-neuronal cells, glutamate is an extracellular signaling mediator. Since podocytes have glutamate-containing vesicles, we sought to determine glutamate receptor presence and action in glomerular cells. The metabotropic glutamate receptors (mGluR) 1, 5, 6, and 8 were found to be expressed in mouse brain and glomeruli; predominantly in podocytes ...
Xinyue Liang +11 more
openaire +2 more sources
BMC Neuroscience, 2008 Background Many studies have focused on the implication of the serotonin and dopamine systems in neuroadaptive responses to the recreational drug 3,4-methylenedioxy-metamphetamine (MDMA).
Malki Rana +3 more
doaj +1 more source