Results 91 to 100 of about 44,093 (262)

Amygdala-prefrontal pathways and the dopamine system affect nociceptive responses in the prefrontal cortex

BMC Neuroscience, 2011
Background We previously demonstrated nociceptive discharges to be evoked by mechanical noxious stimulation in the prefrontal cortex (PFC). The nociceptive responses recorded in the PFC are conceivably involved in the affective rather than the sensory ...
Onozawa Kitaro, Yagasaki Yuki, Izawa Yumi, Abe Hiroyuki, Kawakami Yoriko   +4 more
doaj   +1 more source

Analysis of the Gut Microbiota and Inflammatory Factors in mGluR5-Knockout Mice

Frontiers in Psychiatry, 2020
IntroductionAccumulating evidence indicates that the glutamatergic system plays an important role in the development of depression. Notably, the antidepressant effect of metabotropic glutamate receptor 5 (mGluR5) modulation is inconsistent across studies.
Guohong Cai, Yuanyuan Zhu, Jing Chen, Suo Zhao, Liying Wang, Mengmeng Wang, Jing Huang, Shengxi Wu   +7 more
doaj   +1 more source

Functional Disconnections of the Pre-Supplementary Motor Area in Patients With Post-Stroke Aphasia and Their Associations With Neurotransmitters. [PDF]

CNS Neurosci Ther
Our findings suggest that functional connections of the preSMA are disrupted in PSA patients, which may be associated with neurotransmitter activity, possibly serving as the predictive markers for recovery of PSA. ABSTRACT Background The pre‐supplementary motor area (preSMA) is a critical region within domain‐general networks involved in speech ...
Wang D, Wang X, Xu X, Zheng K, Jiang D, Huang G, Sun L, Leng H, Yang Z, Zhang G, Zhao Z, Ren C.   +11 more
europepmc   +2 more sources

Investigation of the antidyskinetic site of action of metabotropic and ionotropic glutamate receptor antagonists. Intracerebral infusions in 6-hydroxydopamine-lesioned rats with levodopa-induced dyskinesia

European Journal of Pharmacology, 2012
Long-term levodopa replacement therapy in Parkinson's disease is confounded by abnormal involuntary movements, known as levodopa induced dyskinesia (LID). Dysfunctional glutamatergic neurotransmission has been implicated in the pathogenesis of LID making metabotropic and ionotropic glutamate receptors attractive novel therapeutic targets. The objective
Maranis, S., Stamatis, D., Tsironis, C., Konitsiotis, S.   +3 more
openaire   +4 more sources

The mysterious middlemen making your vision pop: understanding the function of amacrine cells

The Journal of Physiology, EarlyView.
Abstract figure legend This review aims to illustrate the diversity and function of amacrine cells in the retina. The diversity of amacrine cell subtypes is depicted based on morphology, stratification and neurotransmitter expression, along with their synaptic connectivity with bipolar and ganglion cells, emphasizing inhibitory and modulatory roles ...
Victor Calbiague‐Garcia, Deborah Varro, Thomas Buffet, Olivier Marre   +3 more
wiley   +1 more source

Diverse Subpopulations of Reactive Astrocytes Following Chronic Toxoplasma Infection

Glia, Volume 73, Issue 10, Page 2003-2024, October 2025.
Main Points Toxoplasma infection results in distinct astrocyte subpopulations. Chronically labeled reactive astrocytes appear transcriptionally plastic and can regain acute inflammatory responding and naive homeostatic astrocytic gene patterns in the presence of ongoing neuroinflammation.
Zoe A. Figueroa, Jose L. Martin, Arzu Ulu, William Agnew‐Svoboda, Teresa Ubina, Martin M. Riccomagno, Todd A. Fiacco, Emma H. Wilson   +7 more
wiley   +1 more source

Beyond the tumor: Enhancing pancreatic cancer therapy through glutamine metabolism and innovative drug delivery

Journal of Cell Communication and Signaling, Volume 19, Issue 3, September 2025.
The top row shows key drivers‐KRAS, c‐Myc and HIF‐1a‐alongside gut and tumor microbiota, all converging on glutamine metabolism in PDAC. At the center, glutamine handling is depicted as the linchpin of tumor growth, biosynthesis and immune modulation. The green panel lists major intervention strategies: DON‐loaded nanoparticles, prodrugs (DRP‐104/JHU ...
Min Su, Huan Qin, Jie Shen, Hao An, Yu Cao   +4 more
wiley   +1 more source

Glutamatergic neurotransmission modulates hypoxia-induced hyperventilation but not anapyrexia

Brazilian Journal of Medical and Biological Research, 2004
The interaction between pulmonary ventilation (V E) and body temperature (Tb) is essential for O2 delivery to match metabolic rate under varying states of metabolic demand.
Paula P.M. de, Branco L.G.S.
doaj  

Finely Tuned Gamma Oscillations in the Globus Pallidus Internus in Parkinson's Disease

Movement Disorders Clinical Practice, EarlyView.
Hikaru Kamo, Mallory L.S. Eisel, Jackson N. Cagle, Kara A. Johnson, Joshua Wong, Coralie de Hemptinne   +5 more
wiley   +1 more source

Molecular architecture of language‐related cortical areas revealed by integrative proteomic and connectome analyses

Clinical and Translational Medicine, Volume 15, Issue 9, September 2025.
Wu et al. studied why certain brain areas are more connected than others. They found that areas with similar protein patterns tend to work together more closely. Additionally, they found when one area is affected such as in brain tumours, other areas with similar patterns especially contralateral regions might help.
Jinsong Wu, Zixian Wang, Fengjiao Li, Shuolei Bu, Lianglong Sun, Chen Zheng, Zhixin Bai, Luhao Yang, Fangyuan Gong, Jiali Chen, Yien Huang, Wanjing Li, Guoquan Yan, Weiwei Xian, Jiaxuan Yang, Shuai Wu, Kemin Zhu, Wenke Fan, Qiong Liu, Guomin Zhou, Gong‐Hong Wei, Wensheng Li, Jing Yan, Jingliang Cheng, Russell G. Snell, Maurice A. Curtis, Tianye Jia, Binke Yuan, Yong He, Weijiang Zhang, Linya You   +30 more
wiley   +1 more source