Results 91 to 100 of about 52,301 (266)

L-DOPA-Induced Motor Impairment and Overexpression of Corticostriatal Synaptic Components Are Improved by the mGluR5 Antagonist MPEP in 6-OHDA-Lesioned Rats

ASN Neuro, 2018
Levodopa (L-DOPA) is still the most effective drug for the treatment of Parkinson’s disease (PD). However, the long-term therapy often triggers L-DOPA-induced dyskinesia (LID).
Yixian Huang, Haiyang Shu, Li Li, Tili Zhen, Junyan Zhao, Xianju Zhou, Weifeng Luo   +6 more
doaj   +1 more source

Shedding of Microvesicles from Microglia Contributes to the Effects Induced by Metabotropic Glutamate Receptor 5 Activation on Neuronal Death

Frontiers in Pharmacology, 2017
Metabotropic glutamate (mGlu) receptor 5 is involved in neuroinflammation and has been shown to mediate reduced inflammation and neurotoxicity and to modify microglia polarization.
Martina Beneventano, Simona F. Spampinato, Sara Merlo, Mariangela Chisari, Paola Platania, Marco Ragusa, Michele Purrello, Ferdinando Nicoletti, Ferdinando Nicoletti, Maria Angela Sortino   +9 more
doaj   +1 more source

The G protein-coupled receptor heterodimer network (GPCR-HetNet) and its hub components [PDF]

, 2014
G protein-coupled receptors (GPCRs) oligomerization has emerged as a vital characteristic of receptor structure. Substantial experimental evidence supports the existence of GPCR-GPCR interactions in a coordinated and cooperative manner.
Agnati, Luigi F, Borroto-Escuela, Dasiel O, Brito, Ismel, Di Palma, Michael, Duchou, Jolien, Fuxe, Kjell, Guidolin, Diego, Oflijan, Julia, Rivera, Alicia, Romero-Fernandez, Wilber, Skieterska, Kamila, Suárez-Boomgaard, Diana, Van Craenenbroeck, Kathleen   +12 more
core   +4 more sources

Psychedelics as pharmacotherapeutics for substance use disorders: A scoping review on clinical trials and perspectives on underlying neurobiology

British Journal of Pharmacology, EarlyView.
Theorized mechanism of dopamine homeostasis restoration in the nucleus accumbens core induced by a psychedelic intervention. Abstract Psychedelics have garnered great attention in recent years as treatments for major depressive disorder (MDD) and treatment‐resistant depression because of their ability to alter consciousness and afflicted cognitive ...
Lucas Wittenkeller, Gary Gudelsky, T. John Winhusen, Davide Amato   +3 more
wiley   +1 more source

Nitric oxide and synaptic function [PDF]

, 1994
The free radical gas nitric oxide (NO) is a recently identified neuronal messenger that carries out diverse signaling tasks in both the central and peripheral nervous systems.
Madison, Daniel V., Schuman, Erin M.
core   +1 more source

Is there a role for cannabidiol in obesity, metabolic syndrome and binge eating?

British Journal of Pharmacology, EarlyView.
Cannabidiol (CBD) is one of the most abundant phytocannabinoids isolated from the Cannabis sativa plant. CBD is a lipophilic, non‐intoxicating substance that differently from Δ9‐tetrahydrocannabinol (Δ9‐THC) does not present the typical profile of a drug of abuse.
Luca Botticelli, Emanuela Micioni Di Bonaventura, Giacomo Einaudi, Gustavo Provensi, Alessia Costa, Claudio D'Addario, Carlo Cifani, Maria Vittoria Micioni Di Bonaventura   +7 more
wiley   +1 more source

Improved retinal function in RCS rats after suppressing the over-activation of mGluR5

Scientific Reports, 2017
Müller cells maintain retinal synaptic homeostasis by taking up glutamate from the synaptic cleft and transporting glutamine back to the neurons. To study the interaction between Müller cells and photoreceptors, we injected either DL-α-aminoadipate or L ...
Jiaman Dai, Yan Fu, Yuxiao Zeng, Shiying Li, Zheng Qin Yin   +4 more
doaj   +1 more source

Improved Visualization and Specific Binding for Metabotropic Glutamate Receptor Subtype 1 (mGluR1) Using [11C]ITMM with Ultra-High Specific Activity in Small-Animal PET. [PDF]

PLoS ONE, 2015
Metabotropic glutamate receptor subtype 1 (mGluR1) is a crucial target in the development of new medications to treat central nervous system (CNS) disorders.
Tomoteru Yamasaki, Masayuki Fujinaga, Joji Yui, Hidekatsu Wakizaka, Tomoyuki Ohya, Nobuki Nengaki, Masanao Ogawa, Yoko Ikoma, Akiko Hatori, Lin Xie, Kazunori Kawamura, Ming-Rong Zhang   +11 more
doaj   +1 more source

Augmented Cystine–Glutamate Exchange by Pituitary Adenylate Cyclase-activating Polypeptide Signaling via the VPAC1 Receptor [PDF]

, 2014
In the central nervous system, cystine import in exchange for glutamate through system xc- is critical for the production of the antioxidant glutathione by astrocytes, as well as the maintenance of extracellular glutamate. Therefore, regulation of system
Arimura, Ashur-Fabian, Asztely, Baker, Baker, Baker, Bannai, Bannai, Barger, Berman, Brenneman, Brown, Chen, Choi, Costa, Diamond, Dickson, Dugan, Fahrenkrug, Figiel, Fogal, Ghatei, Grant, Grant, Grimaldi, Grimaldi, Groot, Hannibal, Hannibal, Hashimoto, Jackman, Johnson, Joo, Joo, Knackstedt, Kranich, Kupchik, Lewerenz, Liu, Liu, Liu, Liu, Lobner, Macdonald, Magistretti, Martin, Masmoudi-Kouki, Masmoudi-Kouki, Moran, Morio, Murphy, Park, Piani, Pow, Rush, Rush, Sagara, Said, Sato, Schwartz, Seaborn, Shih, Shintani, Sontheimer, Suh, Suzuki, Tatsuno, Tatsuno, Vaudry, Vaudry, Yaka, Ye, Yuhara, Zheng, Zhou   +74 more
core   +2 more sources

Evaluation of preclinical antipsychotic models used to support first‐in‐human clinical trials

British Journal of Pharmacology, EarlyView.
Abstract Schizophrenia is regarded as a complex and heterogeneous psychiatric disorder, characterised by diverse symptoms and comorbidities, which complicate both clinical management and drug development. Current pharmacological treatment, primarily based on dopamine D2 receptor antagonism or partial agonism, which has not markedly progressed since the
Thi Viet Ha Nguyen, Declan P. McKernan, John P. Kelly   +2 more
wiley   +1 more source