Results 91 to 100 of about 48,931 (264)
ASN Neuro, 2018 Levodopa (L-DOPA) is still the most effective drug for the treatment of Parkinson’s disease (PD). However, the long-term therapy often triggers L-DOPA-induced dyskinesia (LID).
Yixian Huang +6 more
doaj +1 more source
Frontiers in Pharmacology, 2017 Metabotropic glutamate (mGlu) receptor 5 is involved in neuroinflammation and has been shown to mediate reduced inflammation and neurotoxicity and to modify microglia polarization.
Martina Beneventano +9 more
doaj +1 more source
The activation of group II metabotropic glutamate receptors protects neonatal rat brains from oxidative stress injury after hypoxia-ischemia. [PDF]
PLoS ONE, 2018 Birth asphyxia resulting in brain hypoxia-ischemia (H-I) can cause neonatal death or lead to persistent brain damage. Recent investigations have shown that group II metabotropic glutamate receptor (mGluR2/3) activation can provide neuroprotection against
Ewelina Bratek +3 more
doaj +1 more source
British Journal of Pharmacology, EarlyView.Abstract Background and purpose Clozapine, an approved antipsychotic for treatment‐resistant schizophrenia (TRS), enhances glutamatergic transmission by increasing exocytosis and non‐exocytosis glutamate release; however, its full action remained to be clarified.
Motohiro Okada +2 more
wiley +1 more source
Epilepsia, EarlyView.Abstract Objective This study was undertaken to describe a case series of Brazilian new onset refractory status epilepticus (NORSE) patients and evaluate the sensitivity and specificity of a clinical score to predict cryptogenic etiology (c‐NORSE score) after autoimmune encephalitis (AE) testing.
João Henrique Fregadolli Ferreira +42 more
wiley +1 more source
Improved retinal function in RCS rats after suppressing the over-activation of mGluR5
Scientific Reports, 2017 Müller cells maintain retinal synaptic homeostasis by taking up glutamate from the synaptic cleft and transporting glutamine back to the neurons. To study the interaction between Müller cells and photoreceptors, we injected either DL-α-aminoadipate or L ...
Jiaman Dai +4 more
doaj +1 more source
Improved Visualization and Specific Binding for Metabotropic Glutamate Receptor Subtype 1 (mGluR1) Using [11C]ITMM with Ultra-High Specific Activity in Small-Animal PET. [PDF]
PLoS ONE, 2015 Metabotropic glutamate receptor subtype 1 (mGluR1) is a crucial target in the development of new medications to treat central nervous system (CNS) disorders.
Tomoteru Yamasaki +11 more
doaj +1 more source
Epilepsia, EarlyView.Abstract Objective Drug‐resistant epilepsy (DRE) affects >25 million people worldwide and is often associated with neuroinflammation. Increasing evidence links deficiency or malfunctioning of the enzyme phosphoglycerate dehydrogenase (PHGDH), which converts 3‐phosphoglycerate to generate serine and the neurotransmitter glycine, with (drug‐resistant ...
Karin Thevissen +25 more
wiley +1 more source
GABA<sub>B</sub> Receptors Mediate Intracellular Calcium Release in Astrocytes of the Prefrontal Cortex. [PDF]
Eur J NeurosciWe took advantage of GLAST‐promoter driven GCaMP6s expression in astrocytes to study Ca2+ signaling in astrocytes of the young adult prefrontal cortex in response to GABA with confocal Ca2+ imaging. The results show that GABA induces Ca2+ signaling via the stimulation of the metabotropic GABAB receptor in astrocytes.
Bostel J, Kürten AJ, Beiersdorfer A.
europepmc +2 more sources
Wwox deletion leads to reduced GABA-ergic inhibitory interneuron numbers and activation of microglia and astrocytes in mouse hippocampus [PDF]
, 2019 The association of WW domain-containing oxidoreductase WWOX gene loss of function with central nervous system (CNS) related pathologies is well documented.
Abba, Martín Carlos +11 more
core +2 more sources