Results 101 to 110 of about 48,931 (264)

Lower density of calretinin‐immunopositive neurons in the putamen of subjects with schizophrenia

Journal of Anatomy, Volume 246, Issue 4, Page 505-516, April 2025.
Recent neuroimaging and histological studies highlight the striatum as a key area involved in SCH, but the specific impairment of neuronal subtypes in subcortical structures is not fully understood. This study is the first detailed investigation of neuroanatomical changes in the putamen in SCH, specifically examining the density of calretinin ...
Paz Kelmer, Paulina Hoppa, Erzsébet Frank, Teadora Tyler, Istvan Adorjan   +4 more
wiley   +1 more source

Analysis of the Gut Microbiota and Inflammatory Factors in mGluR5-Knockout Mice

Frontiers in Psychiatry, 2020
IntroductionAccumulating evidence indicates that the glutamatergic system plays an important role in the development of depression. Notably, the antidepressant effect of metabotropic glutamate receptor 5 (mGluR5) modulation is inconsistent across studies.
Guohong Cai, Yuanyuan Zhu, Jing Chen, Suo Zhao, Liying Wang, Mengmeng Wang, Jing Huang, Shengxi Wu   +7 more
doaj   +1 more source

Therapeutic Targeting of the α7 Nicotinic Receptor: Challenges and Prospects for Cognitive Improvement in Alzheimer's and Schizophrenia [PDF]

Basic Clin Pharmacol Toxicol
ABSTRACT The α7 nicotinic acetylcholine receptor (α7 nAChR) has emerged as a key target for treating cognitive dysfunction in neurological disorders such as Alzheimer's disease (AD) and schizophrenia. α7 nAChRs play essential roles in neurotransmission, neuroinflammation and synaptic plasticity, not only in neurons but also in glial cells, where they ...
Magnussen J.
europepmc   +2 more sources

A population of immature cerebellar parallel fibre synapses are insensitive to adenosine but are inhibited by hypoxia [PDF]

, 2011
The purine adenosine plays an important role in a number of physiological and pathological processes and is neuroprotective during hypoxia and ischemia.
Atterbury, Alison, Wall, Mark J.
core   +1 more source

Selective blockade of mGlu5 metabotropic glutamate receptors is protective against hepatic mitochondrial dysfunction in 6‐OHDA lesioned Parkinsonian rats

Clinical and Experimental Pharmacology and Physiology, 2015
SummaryNon‐motor symptoms including those involving the splanchnic district are present in Parkinson's disease (PD). The authors previously reported that PD‐like rats, bearing a lesion of the nigrostriatal pathway induced by the injection of 6‐hydroxydopamine (6‐OHDA), have impaired hepatic mitochondrial function.
FERRIGNO, ANDREA, VAIRETTI, MARIAPIA, AMBROSI, GIULIA, RIZZO, VITTORIA, RICHELMI, PLINIO, BLANDINI, FABIO, Fuzzati Armentero, Marie Therese   +6 more
openaire   +4 more sources

Non‐ionotropic NMDAR signalling activates Panx1 to induce P2X4R‐dependent long‐term depression in the hippocampus

The Journal of Physiology, EarlyView.
Abstract figure legend Stimulation of the Shaffer collateral pathway at 3 Hz activates non‐ionotropic NMDA receptors. This subsequently leads to Src kinase mediated phosphorylation of pannexin‐1 (Panx1), which releases ATP from the postsynaptic cell. ATP acts as a ligand for P2X4 receptors to induce long‐term depression (LTD). Abstract In recent years,
Allison C. Nielsen, Connor L. Anderson, Carina Ens, Andrew K. J. Boyce, Roger J. Thompson   +4 more
wiley   +1 more source

Amygdala-prefrontal pathways and the dopamine system affect nociceptive responses in the prefrontal cortex

BMC Neuroscience, 2011
Background We previously demonstrated nociceptive discharges to be evoked by mechanical noxious stimulation in the prefrontal cortex (PFC). The nociceptive responses recorded in the PFC are conceivably involved in the affective rather than the sensory ...
Onozawa Kitaro, Yagasaki Yuki, Izawa Yumi, Abe Hiroyuki, Kawakami Yoriko   +4 more
doaj   +1 more source

A PI3K-mediated negative feedback regulates Drosophila motor neuron excitability [PDF]

, 2008
Negative feedback can act as a homeostatic mechanism to maintain neuronal activity at a particular specified value. At the Drosophila neuromuscular junction, a mutation in the type II metabotropic glutamate receptor gene (mGluRA) increased motor neuron ...
Curtis C. J. Lin, Eric Howlett, Michael Stern, William Lavery   +3 more
core   +1 more source

The effect of N-acetyl-aspartyl-glutamate and N-acetyl-aspartate on white matter oligodendrocytes [PDF]

, 2009
Elevations of the levels of N-acetyl-aspartyl-glutamate (NAAG) and N-acetyl-aspartate (NAA) are associated with myelin loss in the leucodystrophies Canavan's disease and Pelizaeus-Merzbacher-like disease. NAAG and NAA can activate and antagonize neuronal
A. Wade, Berger, Bergeron, Billups, Burlina, Bzdega, Chakraborty, Chatterton, D'Angelo, D. Attwell, Fenwick, Fields, Follett, Jakobs, Jane, K. Kolodziejczyk, Karadottir, Karadottir, Khwaja, Koenig, Kumar, K  rad  ttir, Li, Micu, N. B. Hamilton, Pliss, R. Karadottir, Rubin, Salter, Sartori, Sekiguchi, Tortella, Valivullah, Westbrook, Wevers, Wolf, Wroblewska   +36 more
core   +2 more sources

Investigation of the antidyskinetic site of action of metabotropic and ionotropic glutamate receptor antagonists. Intracerebral infusions in 6-hydroxydopamine-lesioned rats with levodopa-induced dyskinesia

European Journal of Pharmacology, 2012
Long-term levodopa replacement therapy in Parkinson's disease is confounded by abnormal involuntary movements, known as levodopa induced dyskinesia (LID). Dysfunctional glutamatergic neurotransmission has been implicated in the pathogenesis of LID making metabotropic and ionotropic glutamate receptors attractive novel therapeutic targets. The objective
Maranis, S., Stamatis, D., Tsironis, C., Konitsiotis, S.   +3 more
openaire   +4 more sources