Results 121 to 130 of about 44,093 (262)

Dimerisation of the VIP receptor VIPR2 is essential to its binding VIP and Gαi proteins, and to its functions in breast cancer cells

British Journal of Pharmacology, Volume 182, Issue 15, Page 3612-3627, August 2025.
Abstract Background and Purpose Several G protein‐coupled receptors (GPCRs) are known to homodimerise. Dimeric GPCRs may have different properties from their monomers, but the molecular basis and functional significance of GPCR dimerisation remain largely unknown.
Satoshi Asano, Kairi Ozasa, Teru Uehara, Rei Yokoyama, Takanobu Nakazawa, Souichi Yanamoto, Yukio Ago   +6 more
wiley   +1 more source

Amyloid‐Beta Pathology Increases Synaptic Engulfment by Glia in Feline Cognitive Dysfunction Syndrome: A Naturally Occurring Model of Alzheimer's Disease

European Journal of Neuroscience, Volume 62, Issue 3, August 2025.
McGeachan et al. demonstrate microgliosis, astrogliosis and increased synaptic engulfment by microglia and astrocytes in regions with Aβ plaques in aged cat brains and cats with cognitive dysfunction syndrome (CDS). Microglia and astrocytes also show enhanced internalisation of amyloid‐beta‐containing synapses near plaques.
Robert I. McGeachan, Lucy Ewbank, Meg Watt, Lorena Sordo, Alexandra Malbon, Muhammad Khalid F. Salamat, Makis Tzioras, Joao Miguel De Frias, Jane Tulloch, Fiona Houston, Danièlle Gunn‐Moore, Tara L. Spires‐Jones   +11 more
wiley   +1 more source

Efgartigimod as a Fast‐Acting Add‐On Therapy in Antibody–Mediated Autoimmune Encephalitis

European Journal of Neurology, Volume 32, Issue 8, August 2025.
ABSTRACT Background Autoimmune encephalitis (AE) is a severe neurological disorder that requires effective and safe treatment options. This study aimed to compare the efficacy and safety of intravenous methylprednisolone (IVMP) plus efgartigimod (IPE) versus IVMP alone or IVMP plus immunoglobulin (IPI) as initial treatments for antibody‐mediated AE ...
Zhuajin Bi, Wenzhong Kang, Ruihan Liu, Yan Jiang, Min Chen   +4 more
wiley   +1 more source

Unlocking Relief: Investigating the Impact of a Fixed Combination of Acetyl‐L‐Carnitine and Palmitoylethanolamide on Traumatic Acute Low Back Pain

European Journal of Neurology, Volume 32, Issue 8, August 2025.
This monocentric observational study investigates a fixed combination of acetyl‐L‐carnitine, palmitoylethanolamide, and alpha‐lipoic acid in 48 patients with acute low back pain. Over 8 weeks, treatment led to significant reductions in neuropathic pain scores, decreased NSAID consumption, and improvements in quality of life, supporting its potential ...
Mattia Cominacini, Maria Teresa Valenti, Michele Braggio, Alberto Caramori, Ermes Vedovi, Luca Dalle Carbonare   +5 more
wiley   +1 more source

Psilocybin as Transformative Fast‐Acting Antidepressant: Pharmacological Properties and Molecular Mechanisms

Fundamental &Clinical Pharmacology, Volume 39, Issue 4, August 2025.
ABSTRACT In the 1950s–60s, serotonergic psychedelic drugs were studied as potential adjuvants to psychotherapy to treat addiction and alcoholism. However, starting in the 70s, preclinical and clinical studies on psychedelics stopped for decades because legislation controlled its recreational use, citing their hallucinogenic and psychotomimetic effects,
Makiath Adebo, Mathilda Bonnet, Ons Laouej, Celine Defaix, Josephine C. McGowan, Florence Butlen‐Ducuing, Denis J. David, Erwan Poupon, Laurent Tritschler, Alain M. Gardier   +9 more
wiley   +1 more source

Leveraging Fiber Photometry to Decipher Neural Circuits Underlying Anxiety in Mice

Fundamental &Clinical Pharmacology, Volume 39, Issue 5, October 2025.
ABSTRACT Anxiety disorders rank among the most prevalent mental health conditions worldwide, significantly affecting patients' lives. They are frequently comorbid with other psychiatric disorders, often exacerbating their severity. Current pharmacological treatments; selective serotonin reuptake inhibitors (SSRIs) and benzodiazepines, remain limited in
Salma R. Abdennebi, Nour El Haya Touihri, Emmanuelle Corruble, Denis J. David, Indira Mendez‐David   +4 more
wiley   +1 more source

The novel peptide LCGM-10 attenuates metabotropic glutamate receptor 5 activity and demonstrates behavioral effects in animal models

Frontiers in Behavioral Neuroscience
We employed a structural bioinformatics approach to develop novel peptides with predicted affinity to the binding site for negative allosteric modulators (NAMs) of metabotropic glutamate receptor 5 (mGluR5).
Anton V. Malyshev, Vsevolod V. Pavshintcev, Nikita A. Mitkin, Iuliia A. Sukhanova, Vasilina R. Gedzun, Alexander S. Zlobin, Igor I. Doronin, Gennady A. Babkin, Tomi K. Sawyer   +8 more
doaj   +1 more source

From Neurotransmission to Retinal Pathophysiology: Unraveling the Role of GABA Receptors in Retinal Disease Progression

Journal of Neurochemistry, Volume 169, Issue 8, August 2025.
GABA receptors, widely expressed in the retina, play a key role in lateral inhibition and synaptic regulation. Emerging evidence links their dysregulation to retinal diseases such as diabetic retinopathy, retinitis pigmentosa, glaucoma, and age‐related macular degeneration.
Alan E. Medina Arellano, Jesus Silvestre Albert‐Garay, Nadia Flores Huerta, Karla Tovar Hernández, Matilde Ruiz‐Cruz, Lenin Ochoa‐de la Paz   +5 more
wiley   +1 more source

Non‐ionotropic NMDAR signalling activates Panx1 to induce P2X4R‐dependent long‐term depression in the hippocampus

The Journal of Physiology, Volume 603, Issue 15, Page 4367-4381, 1 August 2025.
Abstract figure legend Stimulation of the Shaffer collateral pathway at 3 Hz activates non‐ionotropic NMDA receptors. This subsequently leads to Src kinase mediated phosphorylation of pannexin‐1 (Panx1), which releases ATP from the postsynaptic cell. ATP acts as a ligand for P2X4 receptors to induce long‐term depression (LTD). Abstract In recent years,
Allison C. Nielsen, Connor L. Anderson, Carina Ens, Andrew K. J. Boyce, Roger J. Thompson   +4 more
wiley   +1 more source

Dual role for pannexin 1 at synapses: regulating functional and morphological plasticity

The Journal of Physiology, Volume 603, Issue 15, Page 4237-4253, 1 August 2025.
Abstract figure legend Pannexin 1 (PANX1) regulation of dendritic spines. The postnatal decrease in PANX1 expression could release key spine cytoskeleton‐regulating proteins enabling spine stabilization. Does the physiological decrease in neuronal PANX1 levels across brain development underlie dendritic spine maturation?
Adriana Casillas Martinez, Leigh E. Wicki‐Stordeur, Annika V. Ariano, Leigh Anne Swayne   +3 more
wiley   +1 more source