Results 151 to 160 of about 48,931 (264)

The novel peptide LCGM-10 attenuates metabotropic glutamate receptor 5 activity and demonstrates behavioral effects in animal models

Frontiers in Behavioral Neuroscience
We employed a structural bioinformatics approach to develop novel peptides with predicted affinity to the binding site for negative allosteric modulators (NAMs) of metabotropic glutamate receptor 5 (mGluR5).
Anton V. Malyshev, Vsevolod V. Pavshintcev, Nikita A. Mitkin, Iuliia A. Sukhanova, Vasilina R. Gedzun, Alexander S. Zlobin, Igor I. Doronin, Gennady A. Babkin, Tomi K. Sawyer   +8 more
doaj   +1 more source

Discovery of N-(5-Fluoropyridin-2-yl)-6-methyl-4-(pyrimidin-5-yloxy)picolinamide (VU0424238): A Novel Negative Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5 Selected for Clinical Evaluation

, 2017
Andrew S. Felts, Alice L. Rodriguez, Anna L. Blobaum, Ryan D. Morrison, Brittney S. Bates, Analisa Thompson Gray, Jerri M. Rook, Mohammed Noor Tantawy, Frank W. Byers, Sichen Chang, Daryl F. Venable, Vincent B. Luscombe, Gilles Tamagnan, Colleen M. Niswender, J. Scott Daniels, Carrie K. Jones, P. Jeffrey Conn, Craig W. Lindsley, Kyle A. Emmitte   +18 more
openalex   +1 more source

Metabotropic glutamate mGluR5 receptor blockade opposes abnormal involuntary movements and the increases in glutamic acid decarboxylase mRNA levels induced by l-DOPA in striatal neurons of 6-hydroxydopamine-lesioned rats [PDF]

, 2009
Norio Yamamoto, Jean‐Jacques Soghomonian   +1 more
openalex   +1 more source

Synthesis and Evaluation in Monkey of [¹⁸F]4-Fluoro-N-methyl-N-(4-(6-(methylamino)pyrimidin-4-yl)thiazol-2-yl)benzamide ([¹⁸F]FIMX): A Promising Radioligand for PET Imaging of Brain Metabotropic Glutamate Receptor 1 (mGluR1) [PDF]

, 2013
Rong Xu, Paolo Zanotti‐Fregonara, Sami S. Zoghbi, Robert L. Gladding, Alicia E. Woock, Robert B. Innis, Victor W. Pike   +6 more
openalex   +1 more source

S2d1-6 Comparative analysis of the movement of the cytoplasmic domains between rhodopsin and metabotropic glutamate receptor(S2-d1: "Protein-Protein Interaction in the Signal Transduction of Rhodopsin",Symposia,Abstract,Meeting Program of EABS & BSJ 2006)

, 2006
Takahiro Yamashita, Akihisa Terakita, Yoshinori Shichida   +2 more
openalex   +2 more sources

Metabotropic glutamate receptor 5 antagonist 2-methyl-6-(phenylethynyl)pyridine (MPEP) microinfusions into the nucleus accumbens shell or ventral tegmental area attenuate the reinforcing effects of nicotine in rats [PDF]

, 2011
Manoranjan S. D’Souza, Athina Markou
openalex   +1 more source

Targeting Excitatory Glutamate Receptors for Morphine Tolerance: A Narrative Review. [PDF]

CNS Neurosci Ther
Huang M, Luo L, Wang W, Xu H, Chen M, Ma X, Xu T.   +6 more
europepmc   +1 more source

Spontaneous partial resolution of autoimmune-mediated brain MRI abnormalities before immunotherapy in anti-metabotropic glutamate receptor 5 encephalitis: a case report. [PDF]

Front Immunol
Chen J, Tang X, Wang L, Guo D, Cao L, Lu K.   +5 more
europepmc   +1 more source

Glutamate-Based Therapeutic Strategies for Schizophrenia: Emerging Approaches Beyond Dopamine. [PDF]

Int J Mol Sci
Fadgyas-Stanculete M, Capatina OO.
europepmc   +1 more source

Assessment of the relationship between synaptic density and metabotropic glutamate receptors in early Alzheimer's disease: a multi-tracer PET study. [PDF]

Alzheimers Res Ther
Salardini E, O'Dell RS, Tchorz E, Nabulsi NB, Huang Y, Carson RE, van Dyck CH, Mecca AP.   +7 more
europepmc   +1 more source