Results 201 to 210 of about 48,931 (264)

Genetic disruption of leucine rich repeat transmembrane protein 4 like 1 induces a pro-social behavioural phenotype in zebrafish

Hillman C, Petracco G, Fontana BD, Scaia MF, Dalla-Vecchia E, Wetton JH, Norton WH, Parker M, Reichmann F.   +8 more
europepmc   +1 more source

ATP and glutamate coordinate contractions in the freshwater sponge Ephydatia muelleri.

J Exp Biol
Ho VR, Goss GG, Leys SP.
europepmc   +1 more source

Chronic interleukin‐6 exposure alters metabotropic glutamate receptor‐activated calcium signalling in cerebellar Purkinje neurons [PDF]

European Journal of Neuroscience, 2004
AbstractChronic central nervous system expression of the cytokine interleukin‐6 (IL‐6) is thought to contribute to the histopathological, pathophysiological, and cognitive deficits associated with various neurological disorders. However, the effects of chronic IL‐6 expression on neuronal function are largely unknown.
T.E. Nelson, Jeffrey G. Netzeband, Donna L. Gruol   +2 more
openaire   +4 more sources

A unilateral 6-hydroxydopamine lesion decreases the expression of metabotropic glutamate receptors in rat substantia nigra

Neuroscience Letters, 2003
Loss of dopaminergic neurons in the substantia nigra pars compacta (SNc) in Parkinson's disease (PD) leads to augmentation of glutamatergic activity in the subthalamic nucleus (STN). Moreover, antagonizing excitotoxicity has yielded mostly symptomatic improvements in experimental animals of PD.
Gang Hu, Ying-Dong Zhang, Bing Gu
  +6 more sources

Impaired behavioral suppression by light in metabotropic glutamate receptor subtype 6-deficient mice

Neuroscience, 2000
The metabotropic glutamate receptor subtype 6 is localized on the dendrites of ON bipolar cells in mammalian retina, and is responsible for synaptic transmission from photoreceptors to ON bipolar cells. We have previously provided electrophysiological evidence that metabotropic glutmate receptor subtype 6-deficient mice have an impairment in the ON ...
S Nakanishi, Hiroshi Sasaki, Yutaka Fukuda, K Nagai, Motoharu Takao, Katsuko Morigiwa, T Shima, Tomomitsu Miyoshi   +7 more
openaire   +4 more sources

Anxiolytic-Like Effects of the Prototypical Metabotropic Glutamate Receptor 5 Antagonist 2-Methyl-6-(phenylethynyl)pyridine in Rodents

The Journal of Pharmacology and Experimental Therapeutics, 2000
Recently, selective and systemically active antagonists for the metabotropic glutamate 5 receptor (mGlu(5)) were discovered, and the most potent derivative was found to be MPEP (2-methyl-6-(phenylethynyl)pyridine). Given the high expression of mGlu(5) receptors in limbic forebrain regions, it was decided to evaluate the anxiolytic potential of MPEP ...
W P, Spooren, A, Vassout, H C, Neijt, R, Kuhn, F, Gasparini, S, Roux, R D, Porsolt, C, Gentsch   +7 more
openaire   +3 more sources

Night blindness-associated mutations in the ligand-binding, cysteine-rich, and intracellular domains of the metabotropic glutamate receptor 6 abolish protein trafficking

Human Mutation, 2007
Mutations in the GRM6 gene, which encodes the metabotropic glutamate receptor 6 (mGluR6), lead to autosomal recessive congenital stationary night blindness (CSNB), which is characterized by loss of night vision due to a defect in signal transmission from photoreceptor to the adjacent ON-bipolar cells in the retina.
Zeitz, C, Forster, U, Neidhardt, J, Feil, S, Kälin, S, Leifert, D, Flor, P J, Berger, W   +7 more
openaire   +4 more sources

Effect of metabotropic glutamate receptor 6 on cell morphology and melanosome transfer in melanocytes

Molecular and Cellular Biochemistry
The melanosome transfer pathway from melanocytes to keratinocytes has been extensively investigated; however, the underlying molecular mechanisms remain unclear. Therefore, the function of metabotropic glutamate receptor 6 (mGluR6) in the control of melanocyte-to-keratinocyte melanosome transfer, intracellular calcium levels in melanocytes, and the ...
Jing, Ni, Guangming, Zhao, Yuejian, Liu, Yi, Yang, Zhiqi, Song   +4 more
openaire   +3 more sources