Results 201 to 210 of about 44,093 (262)
Neuroscience Letters, 2003 Loss of dopaminergic neurons in the substantia nigra pars compacta (SNc) in Parkinson's disease (PD) leads to augmentation of glutamatergic activity in the subthalamic nucleus (STN). Moreover, antagonizing excitotoxicity has yielded mostly symptomatic improvements in experimental animals of PD.
Bin Gu
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Molecular and Cellular Neuroscience, 2020
Although there are numerous strategies to counteract the death of dopaminergic neurons in Parkinson's disease (PD), there are currently no treatments that delay or prevent the disease course, indicating that early protective treatments are needed.
Jian-Nan Zhang +5 more
semanticscholar +4 more sources
Although there are numerous strategies to counteract the death of dopaminergic neurons in Parkinson's disease (PD), there are currently no treatments that delay or prevent the disease course, indicating that early protective treatments are needed.
Jian-Nan Zhang +5 more
semanticscholar +4 more sources
Impaired behavioral suppression by light in metabotropic glutamate receptor subtype 6-deficient mice
Neuroscience, 2000 The metabotropic glutamate receptor subtype 6 is localized on the dendrites of ON bipolar cells in mammalian retina, and is responsible for synaptic transmission from photoreceptors to ON bipolar cells. We have previously provided electrophysiological evidence that metabotropic glutmate receptor subtype 6-deficient mice have an impairment in the ON ...
Motoharu Takao +7 more
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The Journal of Pharmacology and Experimental Therapeutics, 2000 Recently, selective and systemically active antagonists for the metabotropic glutamate 5 receptor (mGlu(5)) were discovered, and the most potent derivative was found to be MPEP (2-methyl-6-(phenylethynyl)pyridine). Given the high expression of mGlu(5) receptors in limbic forebrain regions, it was decided to evaluate the anxiolytic potential of MPEP ...
Will Spooren +7 more
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European Journal of Neuroscience, 1997
AbstractMetabotropic glutamate receptor subtype 6 (mGluR6) is restrictedly expressed in the retinal ON bipolar cells and ablation of mouse mGluR6 by gene targeting results in a loss of ON responses to light stimulus and impairs the detection of visual contrasts.
Johji Inazawa +6 more
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AbstractMetabotropic glutamate receptor subtype 6 (mGluR6) is restrictedly expressed in the retinal ON bipolar cells and ablation of mouse mGluR6 by gene targeting results in a loss of ON responses to light stimulus and impairs the detection of visual contrasts.
Johji Inazawa +6 more
openaire +3 more sources
European Journal of Neuroscience, 2005
AbstractIncreasing evidence implicates glutamate‐mediated excitotoxicity as a contributory factor in dopaminergic cell death in the substantia nigra pars compacta (SNc) in Parkinson's disease (PD). Previous studies have suggested that metabotropic glutamate receptor (mGluR) ligands are neuroprotective against excitotoxicity in vitro.
S. Palmer +5 more
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AbstractIncreasing evidence implicates glutamate‐mediated excitotoxicity as a contributory factor in dopaminergic cell death in the substantia nigra pars compacta (SNc) in Parkinson's disease (PD). Previous studies have suggested that metabotropic glutamate receptor (mGluR) ligands are neuroprotective against excitotoxicity in vitro.
S. Palmer +5 more
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Neurochemical Journal, 2013
We studied the effects of subchronic administration of various nootropic drugs, such as piracetam, phenotropil, noopept, semax, pantogam, and nooglutil on the neurochemical characteristics of metabotropic glutamate mGluRII receptors in the brains of inbred BALB/c and C57BL/6 mice, which differed in their initial indices of exploratory behavior, anxiety,
E. V. Vasileva +2 more
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We studied the effects of subchronic administration of various nootropic drugs, such as piracetam, phenotropil, noopept, semax, pantogam, and nooglutil on the neurochemical characteristics of metabotropic glutamate mGluRII receptors in the brains of inbred BALB/c and C57BL/6 mice, which differed in their initial indices of exploratory behavior, anxiety,
E. V. Vasileva +2 more
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MGluR7 is a presynaptic metabotropic glutamate receptor at ribbon synapses of inner hair cells
The FASEB Journal, 2021Glutamate is the most pivotal excitatory neurotransmitter in the central nervous system. Metabotropic glutamate receptors (mGluRs) dimerize and can couple to inhibitory intracellular signal cascades, thereby protecting glutamatergic neurons from ...
Lisa Klotz, R. Enz
semanticscholar +1 more source
Neuropharmacology, 2001
Glutamate receptors play an essential role in fear-related learning and memory. The present study was designed to assess the role of the group I metabotropic glutamate receptor (mGluR) subtype 5 in the acquisition and retrieval of conditioned fear in rats.
Brigitte Schulz +5 more
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Glutamate receptors play an essential role in fear-related learning and memory. The present study was designed to assess the role of the group I metabotropic glutamate receptor (mGluR) subtype 5 in the acquisition and retrieval of conditioned fear in rats.
Brigitte Schulz +5 more
openaire +3 more sources
Agonists and Antagonists for Group III Metabotropic Glutamate Receptors 6, 7 and 8
Current Topics in Medicinal Chemistry, 2005Metabotropic glutamate receptors (mGluRs) have been implicated in a variety of neurological and psychiatric disorders. This article describes recent progress in the development of agonists and antagonists for mGluR 6, 7, and 8. All of them are conformationally constrained or substituted amino acids, and they act at N-terminal extracellular glutamate ...
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