Results 211 to 220 of about 48,931 (264)

Identification of novel alternatively-spliced mRNA isoforms of metabotropic glutamate receptor 6 gene in rat and human retina

Gene, 2001
Novel splice variants of metabotropic glutamate receptor type 6 (mGlu6 receptor) were identified by reverse transcription-polymerase chain reaction (RT-PCR) amplification and sequence analysis of rat and human retina cDNAs. The new rat mGlu6 receptor mRNA isoform is characterized by an additional exon of 88 nucleotides containing an in frame stop codon,
VALERIO, Alessandra, FERRABOLI, Sergio, PATERLINI M., SPANO, Pier Franco, BARLATI, Sergio   +4 more
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Novel 6-Aryl isoindolin-1-one Derivatives as Negative Allosteric Modulators of Metabotropic Glutamate Receptor 2 [PDF]

ACS Medicinal Chemistry Letters
This highlight describes a series of novel 6-aryl isoindolin-1-one derivatives as negative allosteric modulators (NAMs) of the metabotropic glutamate receptor 2 (mGluR2). The chemical synthesis, selectivity over mGluR3, and pharmaceutical compositions of those compounds are disclosed.
Yinlong Li, Steven H. Liang
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Changes in the Gene Expression of GABAA Receptor α1 and α2 Subunits and Metabotropic Glutamate Receptor 5 in the Basal Ganglia of the Rats with Unilateral 6-Hydroxydopamine Lesion and Embryonic Mesencephalic Grafts

Experimental Neurology, 2001
By using an animal model of parkinsonism, we examined the expression of GABA(A) receptor (R) and metabotropic glutamate receptor (mGluR) 5 in the basal ganglia after transplantation with dopamine-rich tissue. The adult rats were unilaterally lesioned by the injection of 6-hydroxydopamine to their left medial forebrain bundles.
Jiang-Chuan Liu, Hsiang-Shu Yin, Tzong-Shiue Yu, Shwun-De Wang   +3 more
openaire   +4 more sources

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Blockade of metabotropic glutamate receptor 5 attenuates axonal degeneration in 6-hydroxydopamine-induced model of Parkinson's disease

Molecular and Cellular Neuroscience, 2021
Although there are numerous strategies to counteract the death of dopaminergic neurons in Parkinson's disease (PD), there are currently no treatments that delay or prevent the disease course, indicating that early protective treatments are needed.
Hong Zhang, Jian-Nan Zhang, Yan-Lin Huang, Hui Min Yang, Yuan Wang, Li Gu   +5 more
openaire   +3 more sources

The Whole Nucleotide Sequence and Chromosomal Localization of the Gene for Human Metabotropic Glutamate Receptor Subtype 6

European Journal of Neuroscience, 1997
AbstractMetabotropic glutamate receptor subtype 6 (mGluR6) is restrictedly expressed in the retinal ON bipolar cells and ablation of mouse mGluR6 by gene targeting results in a loss of ON responses to light stimulus and impairs the detection of visual contrasts.
Johji Inazawa, T Hashimoto, N Okamoto, Y Tagawa, Y Honda, Y Bessho, Shigetada Nakanishi   +6 more
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Neuroprotective effects of metabotropic glutamate receptor ligands in a 6‐hydroxydopamine rodent model of Parkinson's disease

European Journal of Neuroscience, 2005
AbstractIncreasing evidence implicates glutamate‐mediated excitotoxicity as a contributory factor in dopaminergic cell death in the substantia nigra pars compacta (SNc) in Parkinson's disease (PD). Previous studies have suggested that metabotropic glutamate receptor (mGluR) ligands are neuroprotective against excitotoxicity in vitro.
S. Palmer, David T. Dexter, Krishna P. Datla, Anthony C. Vernon, Martin J. Croucher, Virginia Zbarsky   +5 more
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The effects of nootropic drugs on metabotropic glutamate receptors in the brains of BALB/c and C57BL/6 mice

Neurochemical Journal, 2013
We studied the effects of subchronic administration of various nootropic drugs, such as piracetam, phenotropil, noopept, semax, pantogam, and nooglutil on the neurochemical characteristics of metabotropic glutamate mGluRII receptors in the brains of inbred BALB/c and C57BL/6 mice, which differed in their initial indices of exploratory behavior, anxiety,
E. V. Vasileva, Yu. A. Zolotarev, G. I. Kovalev   +2 more
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The metabotropic glutamate receptor antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP) blocks fear conditioning in rats

Neuropharmacology, 2001
Glutamate receptors play an essential role in fear-related learning and memory. The present study was designed to assess the role of the group I metabotropic glutamate receptor (mGluR) subtype 5 in the acquisition and retrieval of conditioned fear in rats.
Brigitte Schulz, Markus Fendt, Kurt Lingenhöhl, Michael Koch, Fabrizio Gasparini, Rainer Kuhn   +5 more
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Agonists and Antagonists for Group III Metabotropic Glutamate Receptors 6, 7 and 8

Current Topics in Medicinal Chemistry, 2005
Metabotropic glutamate receptors (mGluRs) have been implicated in a variety of neurological and psychiatric disorders. This article describes recent progress in the development of agonists and antagonists for mGluR 6, 7, and 8. All of them are conformationally constrained or substituted amino acids, and they act at N-terminal extracellular glutamate ...
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(S)-Homo-AMPA, a Specific Agonist at the mGlu₆ Subtype of Metabotropic Glutamic Acid Receptors

Journal of Medicinal Chemistry, 1997
Our previous publication (J. Med. Chem. 1996, 39, 3188-3194) described (RS)-2-amino-4-(3-hydroxy-5-methylisoxazol-4-yl)butyric acid (Homo-AMPA) as a highly selective agonist at the mGlu6 subtype of metabotropic excitatory amino acid (EAA) receptors.
Ahmadian, H, Nielsen, B, Bräuner-Osborne, Hans, Johansen, T N, Stensbøl, T B, Sløk, F A, Sekiyama, N, Nakanishi, S, Krogsgaard-Larsen, P, Madsen, U   +9 more
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