Results 211 to 220 of about 52,301 (266)

Retinal Neurochemistry. [PDF]

Brain Sci
Lam DM, Ayoub G.
europepmc   +1 more source

Multimodal neuroimaging reveals brain neurochemical disturbances associated with superoxide dismutase in first-episode drug-naïve schizophrenia. [PDF]

Transl Psychiatry
Zhu Z, Wang Z, Yuan X, Zou Y, Zheng C, Wen Y, Hei G, Song X, Shi Y.   +8 more
europepmc   +1 more source

Differing Patterns of Ionotropic Glutamate Receptor Subunit Gene Expression in Paraventricular Hypothalamic Nucleus Subregions following Angiotensin II Hypertension in Male Mice and Female Mice with Advanced Ovarian Failure.

Neuroendocrinology
Sommer G, Hussein SO, Milner TA, Glass MJ.   +3 more
europepmc   +1 more source

Immunohistological Studies of Metabotropic Glutamate Receptor Subtype 6-Deficient Mice Show No Abnormality of Retinal Cell Organization and Ganglion Cell Maturation

Immunohistological Studies of Metabotropic Glutamate Receptor Subtype 6-Deficient Mice Show No Abnormality of Retinal Cell Organization and Ganglion Cell Maturation
openaire  

Chronic interleukin‐6 exposure alters metabotropic glutamate receptor‐activated calcium signalling in cerebellar Purkinje neurons [PDF]

European Journal of Neuroscience, 2004
AbstractChronic central nervous system expression of the cytokine interleukin‐6 (IL‐6) is thought to contribute to the histopathological, pathophysiological, and cognitive deficits associated with various neurological disorders. However, the effects of chronic IL‐6 expression on neuronal function are largely unknown.
Thomas E, Nelson, Jeffrey G, Netzeband, Donna L, Gruol   +2 more
openaire   +3 more sources

Novel 6-Aryl isoindolin-1-one Derivatives as Negative Allosteric Modulators of Metabotropic Glutamate Receptor 2 [PDF]

ACS Medicinal Chemistry Letters
This highlight describes a series of novel 6-aryl isoindolin-1-one derivatives as negative allosteric modulators (NAMs) of the metabotropic glutamate receptor 2 (mGluR2). The chemical synthesis, selectivity over mGluR3, and pharmaceutical compositions of those compounds are disclosed.
Yinlong Li, Steven H. Liang
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New positive allosteric modulators of the metabotropic glutamate receptor 2 (mGluR2): Identification and synthesis of N-propyl-8-chloro-6-substituted isoquinolones

Bioorganic & Medicinal Chemistry Letters, 2011
A series of N-propyl-8-chloro-6-substituted isoquinolones was identified as positive allosteric modulators of metabotropic glutamate receptor 2 (mGluR2 PAM) via high throughput screening (HTS). The subsequent synthesis and initial SAR exploration that led to the identification of compound 28 is described.
Andrés A, Trabanco, Guillaume, Duvey, José María, Cid, Gregor J, Macdonald, Philippe, Cluzeau, Vanthea, Nhem, Rocco, Furnari, Nadia, Behaj, Géraldine, Poulain, Terry, Finn, Hilde, Lavreysen, Sonia, Poli, Alexandre, Raux, Yves, Thollon, Nicolas, Poirier, David, D'Addona, José Ignacio, Andrés, Robert, Lutjens, Emmanuel, Le Poul, Hassan, Imogai, Jean-Philippe, Rocher   +20 more
openaire   +3 more sources

Activation of spinal group I metabotropic glutamate receptors in rats evokes local glutamate release and spontaneous nociceptive behaviors: effects of 2-methyl-6-(phenylethynyl)-pyridine pretreatment

Neuroscience Letters, 2002
Intrathecal (i.t.) administration of the group I metabotropic glutamate receptor (mGluR) agonist (RS)-3,5-dihydroxyphenylglycine ((RS)-3,5-DHPG) to rats produces an immediate display of spontaneous nociceptive behaviors (SNBs) persisting for up to 10 h after injection (NeuroReport 7 (1996) 2743).
Daniel S, Lorrain, Lucia, Correa, Jeffery, Anderson, Mark, Varney   +3 more
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The metabotropic glutamate receptor antagonist 2‐methyl‐6‐(phenylethynyl) pyridine decreases striatal VGlut2 expression in association with an attenuation of L‐dopa‐induced dyskinesias

Synapse, 2011
AbstractThe striatal glutamatergic hyperactivity is considered critical in the development of levodopa‐induced dyskinesias (LID) in Parkinson's disease (PD). Pharmacological antagonism of the metabotropic glutamate receptors (mGluRs), in particular, the subtype mGluR5, can inhibit the expression of dyskinesia in both rodent and nonhuman primate models ...
C, Marin, M, Bonastre, E, Aguilar, A, Jiménez   +3 more
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