Results 221 to 230 of about 44,093 (262)

New positive allosteric modulators of the metabotropic glutamate receptor 2 (mGluR2): Identification and synthesis of N-propyl-8-chloro-6-substituted isoquinolones

Bioorganic & Medicinal Chemistry Letters, 2011
A series of N-propyl-8-chloro-6-substituted isoquinolones was identified as positive allosteric modulators of metabotropic glutamate receptor 2 (mGluR2 PAM) via high throughput screening (HTS). The subsequent synthesis and initial SAR exploration that led to the identification of compound 28 is described.
Jean-Philippe Rocher, Andrés A. Trabanco, Nadia Behaj, Yves Thollon, Guillaume Albert Jacques Duvey, Vanthea Nhem, Robert Johannes Lütjens, Philippe Cluzeau, Rocco Furnari, José María Cid, José Ignacio Andrés, Hassan Julien Imogai, Sonia Poli, Hilde Lavreysen, David D’Addona, Alexandre Raux, Gregor James Macdonald, Nicolas Poirier, Emmanuel Le Poul, Terry Patrick Finn, Géraldine Poulain   +20 more
openaire   +3 more sources

Pharmacological Effects of the Metabotropic Glutamate Receptor 1 Antagonist Compared with Those of the Metabotropic Glutamate Receptor 5 Antagonist and Metabotropic Glutamate Receptor 2/3 Agonist in Rodents: Detailed Investigations with a Selective Allosteric Metabotropic Glutamate Receptor 1 Antagonist, FTIDC [4-[1-(2-Fluoropyridine-3-yl)-5-methyl-1 H-1,2,3-triazol-4-yl]-N-isopropyl-N-methyl-3,6-dihydropyridine-1(2 H)-carboxamide]

The Journal of Pharmacology and Experimental Therapeutics, 2008
The functional roles of metabotropic glutamate receptor (mGluR) 1 in integrative brain functions were investigated using a potent and selective mGluR1 allosteric antagonist, FTIDC [4-[1-(2-fluoropyridine-3-yl)-5-methyl-1H-1,2,3-triazol-4-yl]-N-isopropyl-N-methyl-3,6-dihydropyridine-1(2H)-carboxamide], in comparison with the mGluR5 allosteric antagonist
Toshifumi Kimura, Miyuki Fukushima, Satoru Ito, Shunsuke Maehara, Hisashi Ohta, Satoko Ise, Hirohiko Hikichi, Gentaroh Suzuki, Hiroshi Kawamoto, Akio Satow, Takeshi Tanaka   +10 more
openaire   +2 more sources

Effect of metabotropic glutamate receptor subtype 5 antagonist, 2-methyl-6-(phenylethynyl)-pyridine on mechanosensory afferents innervating rat hind paw following inflammation

Neuroscience Letters, 2005
We investigated whether the metabotropic glutamate receptor subtype 5 (mGluR5) selective antagonist, 2-methyl-6-(phenylethynyl)-pyridine (MPEP) has direct effects on primary afferent fiber responses to noxious mechanical stimulation following inflammation.
Mark O. Urban, Xin Su
openaire   +3 more sources

Heterogeneous distribution of AMPA glutamate receptor subunits at the photoreceptor synapses of rodent retina

European Journal of Neuroscience, 2001
I. Hack, Moritz Frech, O. Dick, L. Peichl, J. Brandstätter   +4 more
semanticscholar   +1 more source

Systemic therapy for hormone receptor‐positive/human epidermal growth factor receptor 2‐negative early stage and metastatic breast cancer

Ca-A Cancer Journal for Clinicians, 2023
Laura A Huppert, Hope S Rugo
exaly  

Pet imaging of type 1 metabotropic glutamate receptors in a family with spinocerebellar ataxia type 6

Journal of the Neurological Sciences, 2017
Kenji Ishii, Yoshiharu Miura, Kei Wagatsuma, Jun Toyohara, Kenji Ishibashi   +4 more
openaire   +2 more sources

Critical care management of chimeric antigen receptor T‐cell therapy recipients

Ca-A Cancer Journal for Clinicians, 2022
Alexander Shimabukuro-vornhagen, Victoria Metaxa, Elie Azoulay   +2 more
exaly  

Chimeric antigen receptor T‐cell therapy in multiple myeloma: A comprehensive review of current data and implications for clinical practice

Ca-A Cancer Journal for Clinicians, 2023
Rujul H Parikh
exaly  

Current treatment and recent progress in gastric cancer

Ca-A Cancer Journal for Clinicians, 2021
Smita S Joshi, Brian D Badgwell
exaly  

A review of cancer immunotherapy toxicity

Ca-A Cancer Journal for Clinicians, 2020
Lucy Boyce Kennedy
exaly