Results 221 to 230 of about 51,960 (263)

The Whole Nucleotide Sequence and Chromosomal Localization of the Gene for Human Metabotropic Glutamate Receptor Subtype 6

European Journal of Neuroscience, 1997
AbstractMetabotropic glutamate receptor subtype 6 (mGluR6) is restrictedly expressed in the retinal ON bipolar cells and ablation of mouse mGluR6 by gene targeting results in a loss of ON responses to light stimulus and impairs the detection of visual contrasts.
T, Hashimoto, J, Inazawa, N, Okamoto, Y, Tagawa, Y, Bessho, Y, Honda, S, Nakanishi   +6 more
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Agonists and Antagonists for Group III Metabotropic Glutamate Receptors 6, 7 and 8

Current Topics in Medicinal Chemistry, 2005
Metabotropic glutamate receptors (mGluRs) have been implicated in a variety of neurological and psychiatric disorders. This article describes recent progress in the development of agonists and antagonists for mGluR 6, 7, and 8. All of them are conformationally constrained or substituted amino acids, and they act at N-terminal extracellular glutamate ...
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Anxiolytic-Like Effects of the Prototypical Metabotropic Glutamate Receptor 5 Antagonist 2-Methyl-6-(phenylethynyl)pyridine in Rodents

The Journal of Pharmacology and Experimental Therapeutics, 2000
Recently, selective and systemically active antagonists for the metabotropic glutamate 5 receptor (mGlu(5)) were discovered, and the most potent derivative was found to be MPEP (2-methyl-6-(phenylethynyl)pyridine). Given the high expression of mGlu(5) receptors in limbic forebrain regions, it was decided to evaluate the anxiolytic potential of MPEP ...
W P, Spooren, A, Vassout, H C, Neijt, R, Kuhn, F, Gasparini, S, Roux, R D, Porsolt, C, Gentsch   +7 more
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Activation of metabotropic glutamate receptor 3 enhances interleukin (IL)-1β-stimulated release of IL-6 in cultured human astrocytes

Neuroscience, 2005
Previous studies have demonstrated that human astrocytes express mRNA and receptor protein for group I and II metabotropic glutamate receptors (mGluRs). Whether these receptors can influence the inflammatory and immune response and can modulate the capacity of astrocytes to produce inflammatory cytokines is still unclear.
Aronica, E., Gorter, J.A., Rozemuller, A.J.M., Yankaya, B., Troost, D.   +4 more
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Effect of metabotropic glutamate receptor 6 on cell morphology and melanosome transfer in melanocytes

Molecular and Cellular Biochemistry
The melanosome transfer pathway from melanocytes to keratinocytes has been extensively investigated; however, the underlying molecular mechanisms remain unclear. Therefore, the function of metabotropic glutamate receptor 6 (mGluR6) in the control of melanocyte-to-keratinocyte melanosome transfer, intracellular calcium levels in melanocytes, and the ...
Jing, Ni, Guangming, Zhao, Yuejian, Liu, Yi, Yang, Zhiqi, Song   +4 more
openaire   +2 more sources

Identification of novel alternatively-spliced mRNA isoforms of metabotropic glutamate receptor 6 gene in rat and human retina

Gene, 2001
Novel splice variants of metabotropic glutamate receptor type 6 (mGlu6 receptor) were identified by reverse transcription-polymerase chain reaction (RT-PCR) amplification and sequence analysis of rat and human retina cDNAs. The new rat mGlu6 receptor mRNA isoform is characterized by an additional exon of 88 nucleotides containing an in frame stop codon,
VALERIO, Alessandra, FERRABOLI, Sergio, PATERLINI M., SPANO, Pier Franco, BARLATI, Sergio   +4 more
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The effects of nootropic drugs on metabotropic glutamate receptors in the brains of BALB/c and C57BL/6 mice

Neurochemical Journal, 2013
We studied the effects of subchronic administration of various nootropic drugs, such as piracetam, phenotropil, noopept, semax, pantogam, and nooglutil on the neurochemical characteristics of metabotropic glutamate mGluRII receptors in the brains of inbred BALB/c and C57BL/6 mice, which differed in their initial indices of exploratory behavior, anxiety,
Е. В. Васильева, Yu. A. Zolotarev, Г. И. Ковалев   +2 more
openalex   +2 more sources

(S)-Homo-AMPA, a Specific Agonist at the mGlu₆ Subtype of Metabotropic Glutamic Acid Receptors

Journal of Medicinal Chemistry, 1997
Our previous publication (J. Med. Chem. 1996, 39, 3188-3194) described (RS)-2-amino-4-(3-hydroxy-5-methylisoxazol-4-yl)butyric acid (Homo-AMPA) as a highly selective agonist at the mGlu6 subtype of metabotropic excitatory amino acid (EAA) receptors.
Ahmadian, H, Nielsen, B, Bräuner-Osborne, Hans, Johansen, T N, Stensbøl, T B, Sløk, F A, Sekiyama, N, Nakanishi, S, Krogsgaard-Larsen, P, Madsen, U   +9 more
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Decreased metabotropic glutamate receptor type 1 availability in a patient with spinocerebellar ataxia type 6: A 11C-ITMM PET study

Journal of the Neurological Sciences, 2015
Imaging of metabotropic glutamate receptor type 1 (mGluR1), localized exclusively in the cerebellar Purkinje cells and related to cerebellar function, has recently become possible using positron emission tomography (PET). We report the initial mGluR1 imaging in a 74-year-old woman with spinocerebellar ataxia type 6 (SCA6).The patient and 9 age-matched ...
Kenji, Ishibashi, Yoshiharu, Miura, Kinya, Ishikawa, Kenji, Ishii, Kiichi, Ishiwata   +4 more
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Metabotropic glutamate receptor 5 antagonist 2-methyl-6-(phenylethynyl)pyridine produces antidepressant effects in rats: Role of brain-derived neurotrophic factor

Neuroscience, 2012
Recent studies highlight that the brain glutamate system is involved in the etiology of depression and glutamatergic-targeting drugs are currently being explored as novel antidepressant medications. Previous studies reveal that the selective metabotropic glutamate receptor 5 antagonist 2-methyl-6-(phenylethynyl)pyridine (MPEP) produces antidepressant ...
C Y, Liu, X X, Jiang, Y H, Zhu, D N, Wei
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