Results 221 to 230 of about 52,301 (266)

Blockade of metabotropic glutamate receptor 5 attenuates axonal degeneration in 6-hydroxydopamine-induced model of Parkinson's disease

Molecular and Cellular Neuroscience, 2021
Although there are numerous strategies to counteract the death of dopaminergic neurons in Parkinson's disease (PD), there are currently no treatments that delay or prevent the disease course, indicating that early protective treatments are needed.
Jian-Nan, Zhang, Yan-Lin, Huang, Hui-Min, Yang, Yuan, Wang, Li, Gu, Hong, Zhang   +5 more
openaire   +2 more sources

Impaired behavioral suppression by light in metabotropic glutamate receptor subtype 6-deficient mice

Neuroscience, 2000
The metabotropic glutamate receptor subtype 6 is localized on the dendrites of ON bipolar cells in mammalian retina, and is responsible for synaptic transmission from photoreceptors to ON bipolar cells. We have previously provided electrophysiological evidence that metabotropic glutmate receptor subtype 6-deficient mice have an impairment in the ON ...
M, Takao, K, Morigiwa, H, Sasaki, T, Miyoshi, T, Shima, S, Nakanishi, K, Nagai, Y, Fukuda   +7 more
openaire   +2 more sources

A unilateral 6-hydroxydopamine lesion decreases the expression of metabotropic glutamate receptors in rat substantia nigra

Neuroscience Letters, 2003
Loss of dopaminergic neurons in the substantia nigra pars compacta (SNc) in Parkinson's disease (PD) leads to augmentation of glutamatergic activity in the subthalamic nucleus (STN). Moreover, antagonizing excitotoxicity has yielded mostly symptomatic improvements in experimental animals of PD.
Bing, Gu, Ying-Dong, Zhang, Gang, Hu
openaire   +3 more sources

The metabotropic glutamate receptor antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP) blocks fear conditioning in rats

Neuropharmacology, 2001
Glutamate receptors play an essential role in fear-related learning and memory. The present study was designed to assess the role of the group I metabotropic glutamate receptor (mGluR) subtype 5 in the acquisition and retrieval of conditioned fear in rats.
B, Schulz, M, Fendt, F, Gasparini, K, Lingenhöhl, R, Kuhn, M, Koch   +5 more
openaire   +2 more sources

Neuroprotective effects of metabotropic glutamate receptor ligands in a 6‐hydroxydopamine rodent model of Parkinson's disease

European Journal of Neuroscience, 2005
AbstractIncreasing evidence implicates glutamate‐mediated excitotoxicity as a contributory factor in dopaminergic cell death in the substantia nigra pars compacta (SNc) in Parkinson's disease (PD). Previous studies have suggested that metabotropic glutamate receptor (mGluR) ligands are neuroprotective against excitotoxicity in vitro.
A C, Vernon, S, Palmer, K P, Datla, V, Zbarsky, M J, Croucher, D T, Dexter   +5 more
openaire   +2 more sources

The Whole Nucleotide Sequence and Chromosomal Localization of the Gene for Human Metabotropic Glutamate Receptor Subtype 6

European Journal of Neuroscience, 1997
AbstractMetabotropic glutamate receptor subtype 6 (mGluR6) is restrictedly expressed in the retinal ON bipolar cells and ablation of mouse mGluR6 by gene targeting results in a loss of ON responses to light stimulus and impairs the detection of visual contrasts.
T, Hashimoto, J, Inazawa, N, Okamoto, Y, Tagawa, Y, Bessho, Y, Honda, S, Nakanishi   +6 more
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Agonists and Antagonists for Group III Metabotropic Glutamate Receptors 6, 7 and 8

Current Topics in Medicinal Chemistry, 2005
Metabotropic glutamate receptors (mGluRs) have been implicated in a variety of neurological and psychiatric disorders. This article describes recent progress in the development of agonists and antagonists for mGluR 6, 7, and 8. All of them are conformationally constrained or substituted amino acids, and they act at N-terminal extracellular glutamate ...
openaire   +2 more sources

Anxiolytic-Like Effects of the Prototypical Metabotropic Glutamate Receptor 5 Antagonist 2-Methyl-6-(phenylethynyl)pyridine in Rodents

The Journal of Pharmacology and Experimental Therapeutics, 2000
Recently, selective and systemically active antagonists for the metabotropic glutamate 5 receptor (mGlu(5)) were discovered, and the most potent derivative was found to be MPEP (2-methyl-6-(phenylethynyl)pyridine). Given the high expression of mGlu(5) receptors in limbic forebrain regions, it was decided to evaluate the anxiolytic potential of MPEP ...
W P, Spooren, A, Vassout, H C, Neijt, R, Kuhn, F, Gasparini, S, Roux, R D, Porsolt, C, Gentsch   +7 more
openaire   +2 more sources

Activation of metabotropic glutamate receptor 3 enhances interleukin (IL)-1β-stimulated release of IL-6 in cultured human astrocytes

Neuroscience, 2005
Previous studies have demonstrated that human astrocytes express mRNA and receptor protein for group I and II metabotropic glutamate receptors (mGluRs). Whether these receptors can influence the inflammatory and immune response and can modulate the capacity of astrocytes to produce inflammatory cytokines is still unclear.
Aronica, E., Gorter, J.A., Rozemuller, A.J.M., Yankaya, B., Troost, D.   +4 more
openaire   +5 more sources

Effect of metabotropic glutamate receptor 6 on cell morphology and melanosome transfer in melanocytes

Molecular and Cellular Biochemistry
The melanosome transfer pathway from melanocytes to keratinocytes has been extensively investigated; however, the underlying molecular mechanisms remain unclear. Therefore, the function of metabotropic glutamate receptor 6 (mGluR6) in the control of melanocyte-to-keratinocyte melanosome transfer, intracellular calcium levels in melanocytes, and the ...
Jing, Ni, Guangming, Zhao, Yuejian, Liu, Yi, Yang, Zhiqi, Song   +4 more
openaire   +2 more sources