Results 231 to 240 of about 52,301 (266)

Identification of novel alternatively-spliced mRNA isoforms of metabotropic glutamate receptor 6 gene in rat and human retina

Gene, 2001
Novel splice variants of metabotropic glutamate receptor type 6 (mGlu6 receptor) were identified by reverse transcription-polymerase chain reaction (RT-PCR) amplification and sequence analysis of rat and human retina cDNAs. The new rat mGlu6 receptor mRNA isoform is characterized by an additional exon of 88 nucleotides containing an in frame stop codon,
VALERIO, Alessandra, FERRABOLI, Sergio, PATERLINI M., SPANO, Pier Franco, BARLATI, Sergio   +4 more
openaire   +3 more sources

(S)-Homo-AMPA, a Specific Agonist at the mGlu₆ Subtype of Metabotropic Glutamic Acid Receptors

Journal of Medicinal Chemistry, 1997
Our previous publication (J. Med. Chem. 1996, 39, 3188-3194) described (RS)-2-amino-4-(3-hydroxy-5-methylisoxazol-4-yl)butyric acid (Homo-AMPA) as a highly selective agonist at the mGlu6 subtype of metabotropic excitatory amino acid (EAA) receptors.
Ahmadian, H, Nielsen, B, Bräuner-Osborne, Hans, Johansen, T N, Stensbøl, T B, Sløk, F A, Sekiyama, N, Nakanishi, S, Krogsgaard-Larsen, P, Madsen, U   +9 more
openaire   +3 more sources

Decreased metabotropic glutamate receptor type 1 availability in a patient with spinocerebellar ataxia type 6: A 11C-ITMM PET study

Journal of the Neurological Sciences, 2015
Imaging of metabotropic glutamate receptor type 1 (mGluR1), localized exclusively in the cerebellar Purkinje cells and related to cerebellar function, has recently become possible using positron emission tomography (PET). We report the initial mGluR1 imaging in a 74-year-old woman with spinocerebellar ataxia type 6 (SCA6).The patient and 9 age-matched ...
Kenji, Ishibashi, Yoshiharu, Miura, Kinya, Ishikawa, Kenji, Ishii, Kiichi, Ishiwata   +4 more
openaire   +2 more sources

The effects of nootropic drugs on metabotropic glutamate receptors in the brains of BALB/c and C57BL/6 mice

Neurochemical Journal, 2013
We studied the effects of subchronic administration of various nootropic drugs, such as piracetam, phenotropil, noopept, semax, pantogam, and nooglutil on the neurochemical characteristics of metabotropic glutamate mGluRII receptors in the brains of inbred BALB/c and C57BL/6 mice, which differed in their initial indices of exploratory behavior, anxiety,
E. V. Vasileva, Yu. A. Zolotarev, G. I. Kovalev   +2 more
openaire   +1 more source

Metabotropic glutamate receptor 5 antagonist 2-methyl-6-(phenylethynyl)pyridine produces antidepressant effects in rats: Role of brain-derived neurotrophic factor

Neuroscience, 2012
Recent studies highlight that the brain glutamate system is involved in the etiology of depression and glutamatergic-targeting drugs are currently being explored as novel antidepressant medications. Previous studies reveal that the selective metabotropic glutamate receptor 5 antagonist 2-methyl-6-(phenylethynyl)pyridine (MPEP) produces antidepressant ...
C Y, Liu, X X, Jiang, Y H, Zhu, D N, Wei
openaire   +2 more sources

Effect of metabotropic glutamate receptor subtype 5 antagonist, 2-methyl-6-(phenylethynyl)-pyridine on mechanosensory afferents innervating rat hind paw following inflammation

Neuroscience Letters, 2005
We investigated whether the metabotropic glutamate receptor subtype 5 (mGluR5) selective antagonist, 2-methyl-6-(phenylethynyl)-pyridine (MPEP) has direct effects on primary afferent fiber responses to noxious mechanical stimulation following inflammation.
Xin, Su, Mark O, Urban
openaire   +2 more sources

Chronic, systemic treatment with a metabotropic glutamate receptor 5 antagonist in 6-hydroxydopamine partially lesioned rats reverses abnormal firing of dopaminergic neurons

Brain Research, 2009
Increasing evidence indicates that the excessive glutamate release onto substantia nigra pars compacta (SNpc) dopaminergic neurons may play an important role in the progression of nigral degeneration. We examined the effects of chronic, systemic treatment with 2-methyl-6-(phenylethynyl)-pyridine (MPEP), a selective metabotropic glutamate receptor 5 ...
Li, Chen, Qiao Jun, Zhang, Jian, Liu, Shuang, Wang, Umar, Ali, Zhen Hua, Gui, Yong, Wang   +6 more
openaire   +2 more sources

Mutational Analysis and Molecular Modeling of the Binding Pocket of the Metabotropic Glutamate 5 Receptor Negative Modulator 2-Methyl-6-(phenylethynyl)-pyridine

Molecular Pharmacology, 2003
Metabotropic glutamate (mGlu) 5 is a G-protein-coupled metabotropic glutamate receptor that plays an important role as a modulator of synaptic plasticity, ion channel activity, and excitotoxicity. 2-Methyl-6-(phenylethynyl)-pyridine (MPEP) is a highly potent, noncompetitive, selective, and systemically active antagonist of mGlu5 receptors.
Pari, Malherbe, Nicole, Kratochwil, Marie-Thérèse, Zenner, Jenny, Piussi, Catherine, Diener, Claudia, Kratzeisen, Christophe, Fischer, Richard H P, Porter   +7 more
openaire   +2 more sources

Night blindness-associated mutations in the ligand-binding, cysteine-rich, and intracellular domains of the metabotropic glutamate receptor 6 abolish protein trafficking

Human Mutation, 2007
Mutations in the GRM6 gene, which encodes the metabotropic glutamate receptor 6 (mGluR6), lead to autosomal recessive congenital stationary night blindness (CSNB), which is characterized by loss of night vision due to a defect in signal transmission from photoreceptor to the adjacent ON-bipolar cells in the retina.
Zeitz, C, Forster, U, Neidhardt, J, Feil, S, Kälin, S, Leifert, D, Flor, P J, Berger, W   +7 more
openaire   +2 more sources

Increased efficacy of μ-opioid agonist-induced antinociception by metabotropic glutamate receptor antagonists in C57BL/6 mice: comparison with (−)-6-phosphonomethyl-deca-hydroisoquinoline-3-carboxylic acid (LY235959)

Psychopharmacology, 2008
Recent experimental data suggest that metabotropic glutamate receptor (mGluR) antagonists with selectivity for mGluR1 and mGluR2/3 enhance morphine-induced antinociception.The present study addressed the hypothesis that mGluR antagonists enhance opioid antinociception by increasing opioid efficacy.The antinociceptive effects of the partial mu-opioid ...
Bradford D, Fischer, Laurence L, Miller, Fredrick E, Henry, Mitchell J, Picker, Linda A, Dykstra   +4 more
openaire   +2 more sources