Results 231 to 240 of about 51,960 (263)

Activation of spinal group I metabotropic glutamate receptors in rats evokes local glutamate release and spontaneous nociceptive behaviors: effects of 2-methyl-6-(phenylethynyl)-pyridine pretreatment

Neuroscience Letters, 2002
Intrathecal (i.t.) administration of the group I metabotropic glutamate receptor (mGluR) agonist (RS)-3,5-dihydroxyphenylglycine ((RS)-3,5-DHPG) to rats produces an immediate display of spontaneous nociceptive behaviors (SNBs) persisting for up to 10 h after injection (NeuroReport 7 (1996) 2743).
Daniel S, Lorrain, Lucia, Correa, Jeffery, Anderson, Mark, Varney   +3 more
openaire   +2 more sources

Effect of metabotropic glutamate receptor subtype 5 antagonist, 2-methyl-6-(phenylethynyl)-pyridine on mechanosensory afferents innervating rat hind paw following inflammation

Neuroscience Letters, 2005
We investigated whether the metabotropic glutamate receptor subtype 5 (mGluR5) selective antagonist, 2-methyl-6-(phenylethynyl)-pyridine (MPEP) has direct effects on primary afferent fiber responses to noxious mechanical stimulation following inflammation.
Xin, Su, Mark O, Urban
openaire   +2 more sources

Chronic, systemic treatment with a metabotropic glutamate receptor 5 antagonist in 6-hydroxydopamine partially lesioned rats reverses abnormal firing of dopaminergic neurons

Brain Research, 2009
Increasing evidence indicates that the excessive glutamate release onto substantia nigra pars compacta (SNpc) dopaminergic neurons may play an important role in the progression of nigral degeneration. We examined the effects of chronic, systemic treatment with 2-methyl-6-(phenylethynyl)-pyridine (MPEP), a selective metabotropic glutamate receptor 5 ...
Li, Chen, Qiao Jun, Zhang, Jian, Liu, Shuang, Wang, Umar, Ali, Zhen Hua, Gui, Yong, Wang   +6 more
openaire   +2 more sources

Mutational Analysis and Molecular Modeling of the Binding Pocket of the Metabotropic Glutamate 5 Receptor Negative Modulator 2-Methyl-6-(phenylethynyl)-pyridine

Molecular Pharmacology, 2003
Metabotropic glutamate (mGlu) 5 is a G-protein-coupled metabotropic glutamate receptor that plays an important role as a modulator of synaptic plasticity, ion channel activity, and excitotoxicity. 2-Methyl-6-(phenylethynyl)-pyridine (MPEP) is a highly potent, noncompetitive, selective, and systemically active antagonist of mGlu5 receptors.
Pari, Malherbe, Nicole, Kratochwil, Marie-Thérèse, Zenner, Jenny, Piussi, Catherine, Diener, Claudia, Kratzeisen, Christophe, Fischer, Richard H P, Porter   +7 more
openaire   +2 more sources

Night blindness-associated mutations in the ligand-binding, cysteine-rich, and intracellular domains of the metabotropic glutamate receptor 6 abolish protein trafficking

Human Mutation, 2007
Mutations in the GRM6 gene, which encodes the metabotropic glutamate receptor 6 (mGluR6), lead to autosomal recessive congenital stationary night blindness (CSNB), which is characterized by loss of night vision due to a defect in signal transmission from photoreceptor to the adjacent ON-bipolar cells in the retina.
Zeitz, C, Forster, U, Neidhardt, J, Feil, S, Kälin, S, Leifert, D, Flor, P J, Berger, W   +7 more
openaire   +2 more sources

Increased efficacy of μ-opioid agonist-induced antinociception by metabotropic glutamate receptor antagonists in C57BL/6 mice: comparison with (−)-6-phosphonomethyl-deca-hydroisoquinoline-3-carboxylic acid (LY235959)

Psychopharmacology, 2008
Recent experimental data suggest that metabotropic glutamate receptor (mGluR) antagonists with selectivity for mGluR1 and mGluR2/3 enhance morphine-induced antinociception.The present study addressed the hypothesis that mGluR antagonists enhance opioid antinociception by increasing opioid efficacy.The antinociceptive effects of the partial mu-opioid ...
Bradford D. Fischer, Laurence L. Miller, Fredrick E. Henry, Mitchell J. Picker, Linda Dykstra   +4 more
openalex   +3 more sources

Attenuation of Behavioral Effects of Cocaine by the Metabotropic Glutamate Receptor 5 Antagonist 2-Methyl-6-(phenylethynyl)-pyridine in Squirrel Monkeys: Comparison with Dizocilpine

The Journal of Pharmacology and Experimental Therapeutics, 2005
Growing evidence suggests a role for metabotropic glutamate receptors (mGluRs) in the behavioral effects of cocaine related to its abuse. The mGluR5 subtype, in particular, has come under scrutiny due to its distribution in brain regions associated with drug addiction.
Buyean, Lee, Donna M, Platt, James K, Rowlett, Adepero S, Adewale, Roger D, Spealman   +4 more
openaire   +2 more sources

The metabotropic glutamate receptor antagonist 2‐methyl‐6‐(phenylethynyl) pyridine decreases striatal VGlut2 expression in association with an attenuation of L‐dopa‐induced dyskinesias

Synapse, 2011
AbstractThe striatal glutamatergic hyperactivity is considered critical in the development of levodopa‐induced dyskinesias (LID) in Parkinson's disease (PD). Pharmacological antagonism of the metabotropic glutamate receptors (mGluRs), in particular, the subtype mGluR5, can inhibit the expression of dyskinesia in both rodent and nonhuman primate models ...
C, Marin, M, Bonastre, E, Aguilar, A, Jiménez   +3 more
openaire   +2 more sources

Systemic therapy for hormone receptor‐positive/human epidermal growth factor receptor 2‐negative early stage and metastatic breast cancer

Ca-A Cancer Journal for Clinicians, 2023
Laura A Huppert, Hope S Rugo
exaly  

Chimeric antigen receptor T‐cell therapy in multiple myeloma: A comprehensive review of current data and implications for clinical practice

Ca-A Cancer Journal for Clinicians, 2023

exaly