Results 21 to 30 of about 44,093 (262)

Profiling prefrontal cortex protein expression in rats exhibiting an incubation of cocaine craving following short-access self-administration procedures

Frontiers in Psychiatry, 2023
IntroductionIncubation of drug-craving refers to a time-dependent increase in drug cue-elicited craving that occurs during protracted withdrawal.
Laura L. Huerta Sanchez, Mathangi Sankaran, Taylor L. Li, Hoa Doan, Alvin Chiu, Eleanora Shulman, Gabriella Shab, Tod E. Kippin, Tod E. Kippin, Tod E. Kippin, Karen K. Szumlinski, Karen K. Szumlinski, Karen K. Szumlinski   +12 more
doaj   +1 more source

Orofacial antinociceptive activity and anchorage molecular mechanism in silico of geraniol [PDF]

Brazilian Oral Research, 2020
We aimed to evaluate the orofacial antinociceptive effect of geraniol in mice and its molecular anchorage mechanism. Seven mice per group (probabilistic sample) were treated with geraniol (12.5, 25 and 50 mg/kg, i.p.), morphine (6 mg/kg, i.p.) and ...
Tereza Karla Vieira Lopes da COSTA, Mariana Silva BARROS, Renan Marrinho BRAGA, Jéssika de Oliveira VIANA, Frederico Barbosa de SOUSA, Luciana SCOTTI, Marcus Tullius SCOTTI, André Ulisses Dantas BATISTA, Reinaldo Nóbrega de ALMEIDA, Ricardo Dias de CASTRO   +9 more
doaj   +1 more source

Can Metabotropic Glutamate Receptor 7 (mGluR 7) be a Novel Target for Analgesia? [PDF]

Journal of Clinical and Diagnostic Research, 2014
Introduction: The present study was carried out to study the role of metabotropic glutamate receptor 7 (mGluR7) using its agonist, N,N’-bis(diphenylmethyl)-1,-ethanediamine (AMN082) for nociceptive stimuli, in animal models.
Shivaprakash G, Punya Suvarna, Sanjay Hadigal, Priyanka Kamath, Natesh Prabhu, Ashok Shenoy K, Pallavi LC   +6 more
doaj   +1 more source

Cerebellar type 1 metabotropic glutamate receptor availability decreases with disease progression in spinocerebellar ataxia type 6

Journal of the Neurological Sciences
Imaging of type 1 metabotropic glutamate receptor (mGluR1), which is predominantly expressed in Purkinje cells, is currently possible using positron emission tomography (PET). We have previously shown that cerebellar mGluR1 availability decreases in patients with cerebellar ataxia and that the degree of ataxia is related to the magnitude of cerebellar ...
Yoshiharu Miura, Kenji Ishibashi
openalex   +3 more sources

Discovery of 4-(5-Membered)Heteroarylether-6-methylpicolinamide Negative Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5

ACS Medicinal Chemistry Letters
This Letter details our efforts to develop novel, non-acetylene-containing metabotropic glutamate receptor subtype 5 (mGlu5) negative allosteric modulators (NAMs) with improved pharmacological properties. This endeavor involved replacing the ether-linked pyrimidine moiety, a metabolic liability, with various 5-membered heterocycles. From this exercise,
Elizabeth S. Childress, Rory A. Capstick, Katherine E. Crocker, Miranda L. Ledyard, Aaron M. Bender, Mallory A. Maurer, Natasha B. Billard, Hyekyung P. Cho, Alice L. Rodriguez, Colleen M. Niswender, Weimin Peng, Jerri M. Rook, Sichen Chang, Anna L. Blobaum, Olivier Boutaud, Analisa Thompson Gray, Carrie K. Jones, P. Jeffrey Conn, Andrew S. Felts, Craig W. Lindsley, Kayla J. Temple   +20 more
openalex   +3 more sources

Functional Availability of ON-Bipolar Cells in the Degenerated Retina: Timing and Longevity of an Optogenetic Gene Therapy

International Journal of Molecular Sciences, 2021
Degenerative diseases of the retina are responsible for the death of photoreceptors and subsequent loss of vision in patients. Nevertheless, the inner retinal layers remain intact over an extended period of time, enabling the restoration of light ...
Jakub Kralik, S. Kleinlogel
semanticscholar   +1 more source

Topological analysis of small leucine-rich repeat proteoglycan nyctalopin. [PDF]

PLoS ONE, 2012
Nyctalopin is a small leucine rich repeat proteoglycan (SLRP) whose function is critical for normal vision. The absence of nyctalopin results in the complete form of congenital stationary night blindness.
Pasano Bojang, Ronald G Gregg
doaj   +1 more source

First evidence for the presence of amino acid sensing mechanisms in the fish gastrointestinal tract

Scientific Reports, 2021
This study aimed to characterize amino acid sensing systems in the gastrointestinal tract (GIT) of the carnivorous fish model species rainbow trout. We observed that the trout GIT expresses mRNAs encoding some amino acid receptors described in mammals ...
Jessica Calo, Ayelén M. Blanco, Sara Comesaña, Marta Conde-Sieira, Sofia Morais, José L. Soengas   +5 more
doaj   +1 more source

Prolonged blockade of NMDA or mGluR5 glutamate receptors reduces nigrostriatal degeneration while inducing selective metabolic changes in the basal ganglia circuitry in a rodent model of Parkinson's disease

Neurobiology of Disease, 2006
We compared the neuroprotective and metabolic effects of chronic treatment with ionotropic or metabotropic glutamate receptor antagonists, in rats bearing a unilateral nigrostriatal lesion induced by 6-hydroxydopamine (6-OHDA). The ionotropic, N-methyl-d-
Marie-Thérèse Armentero, Roberto Fancellu, Giuseppe Nappi, Placido Bramanti, Fabio Blandini   +4 more
doaj   +1 more source

Dataset of eyeblink conditioning in mice treated with the selective mGluR1 antagonist JNJ16259685

Data in Brief, 2023
Eyeblink conditioning is associated with motor learning, which requires the cerebellum and the brainstem. This article provides behavioral data on whether JNJ16259685, a selective metabotropic glutamate receptor type 1 (mGluR1) antagonist, affects ...
Shoichi Tohyama, Yasushi Kishimoto
doaj   +1 more source