Results 51 to 60 of about 44,093 (262)
Journal of Pharmacological Sciences, 2015 The blockade of metabotropic glutamate 5 (mGlu5) receptor has been reported to exert antidepressant effects in several animal models. We previously reported that both ketamine and an mGlu5 receptor antagonist exerted an effect in a novelty-suppressed ...
Kenichi Fukumoto, Shigeyuki Chaki
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Novel 6-Aryl isoindolin-1-one Derivatives as Negative Allosteric Modulators of Metabotropic Glutamate Receptor 2 [PDF]
ACS Medicinal Chemistry LettersThis highlight describes a series of novel 6-aryl isoindolin-1-one derivatives as negative allosteric modulators (NAMs) of the metabotropic glutamate receptor 2 (mGluR2). The chemical synthesis, selectivity over mGluR3, and pharmaceutical compositions of those compounds are disclosed.
Yinlong Li, Steven H. Liang
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Frontiers in Cellular Neuroscience, 2019 BackgroundAstrocytes are now considered as crucial modulators of neuronal synaptic transmission. General anesthetics have been found to inhibit astrocytic activities, but it is not clear whether general anesthetics within the clinical concentration range
Yu Zhang +8 more
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Advanced Biology, EarlyView.Infrared (IR) light evokes distinct calcium and water transport responses in astrocytes, depending on stimulation duration and protocol. This study uses widefield imaging and pharmacology to reveal differential engagement of astroglial signaling pathways.
Wilson R. Adams +7 more
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Deleterious GRM1 mutations in schizophrenia.
PLoS ONE, 2012 We analysed a phenotypically well-characterised sample of 450 schziophrenia patients and 605 controls for rare non-synonymous single nucleotide polymorphisms (nsSNPs) in the GRM1 gene, their functional effects and family segregation.
Mohammed Akli Ayoub +9 more
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Pharmacological Research, 2017 Numerous epidemiological studies suggested that there is a variable cancer risk in patients with Parkinson's disease (PD). However, the underlying mechanisms remain unclear. In the present study, the role of metabotropic glutamate receptor 5 (mGluR5) has been investigated in 6-hydroxydopamine (6-OHDA)-induced PD combined with liver cancer both in vitro
Hui Min Yang +7 more
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Advanced Science, EarlyView.DNA‐Based Genetic and Non‐Genetic Tools for Receptor Engineering. This review highlights recent advances in DNA‐based strategies for receptor engineering, including genetic approaches like domain fusion and site‐directed mutagenesis, as well as non‐genetic methods using functional nucleic acids, DNA nanostructures, and dynamic DNA reactions.
Hexin Nan +4 more
wiley +1 more source
Neural Plasticity, 2015 Age-related alterations in the expression of genes and corticostriatal synaptic plasticity were studied in the dorsal striatum of mice of four age groups from young (2-3 months old) to old (18–24 months of age) animals.
Aisa N. Chepkova +2 more
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Enhancement of Short-Term Memory by Methyl-6-(Phenylethynyl)-Pyridine in the BTBR T+tf/J Mouse Model of Autism Spectrum Disorder [PDF]
Endocrinology and Metabolism, 2015 BackgroundAutism spectrum disorder (ASD) encompasses a range of disorders that are characterized by social and communication deficits and repetitive behaviors.
Haijie Yang, Sung-Oh Huh, Jae Seung Hong
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Frontiers in Cellular Neuroscience, 2021 Autism spectrum disorder (ASD) has a broad range of neurobiological characteristics, including alterations in dendritic spines, where approximately 90% of excitatory synapses occur.
Isabel Barón-Mendoza +5 more
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