Results 111 to 120 of about 112,378 (256)

A combinatorial approach of Proteomics and Systems Biology in unravelling the mechanisms of acute kidney injury (AKI): involvement of NMDA receptor GRIN1 in murine AKI [PDF]

, 2013
BACKGROUND: Acute kidney injury (AKI) is a frequent condition in hospitalised patients undergoing major surgery or the critically ill and is associated with increased mortality.
Delles, C., Husi, H., Mischak, H., Mullen, W., Ortiz, A., Sanchez-Niño, M., Vlahou, A.   +6 more
core   +3 more sources

How copy number variations shape brain developmental disorders: Unraveling the synaptic puzzle

Psychiatry and Clinical Neurosciences, EarlyView.
Neurodevelopmental disorders (NDDs), such as schizophrenia (SCZ), Attention‐deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), learning disabilities, and intellectual disabilities (ID), are highly prevalent. One significant genetic factor associated with NDDs is copy number variations (CNVs), which are structural changes in the ...
Tianqi Wang, Kubra Trabzonlu, Emily Fullard Jones, Yasir Ahmed Syed   +3 more
wiley   +1 more source

Glycine Potentiates AMPA Receptor Function through Metabotropic Activation of GluN2A-containing NMDA Receptors

Frontiers in Molecular Neuroscience, 2016
NMDA receptors are Ca2+-permeable ion channels. The activation of NMDA receptors requires agonist glutamate and co-agonist glycine. Recent evidence indicates that NMDA receptor also has metabotropic function.
Li-Jun Li, Rong Hu, Rong Hu, Brendan Lujan, Juan Chen, Jian-Jian Zhang, Yasuko Nakano, Tian-Yuan Cui, Ming-Xia Liao, Jin-Cao Chen, Hengye Man, Hua Feng, Qi Wan, Qi Wan, Qi Wan, Qi Wan   +15 more
doaj   +1 more source

Ethanol-Associated Changes in Glutamate Reward Neurocircuitry: A Minireview of Clinical and Preclinical Genetic Findings [PDF]

, 2016
Herein, we have reviewed the role of glutamate, the major excitatory neurotransmitter in the brain, in a number of neurochemical, -physiological, and -behavioral processes mediating the development of alcohol dependence.
Aal-Aaboda, Abe, Abulseoud, Ady, Agrawal, Alasmari, Alhaddad, Arriza, Babu, Bard, Bauer, Beattie, Begleiter, Bell, Bell, Bell, Bell, Bell, Bell, Besheer, Besheer, Besheer, Bischoff, Bockaert, Bondy, Bäckström, Béïque, Cannady, Cannella, Carlezon, Chandler, Chandler, Chefer, Chen, Chen, Cicero, Cloninger, Cohen-Gilbert, Comasco, Cotton, Cowen, Cozzoli, Cozzoli, Cozzoli, Crabbe, Danbolt, Das, Ding, Ding, Domart, Edenberg, Edenberg, Ehlers, El-Husseini, Ende, Enoch, Falco, Flatscher-Bader, Floyd, Fotuhi, Funke, Garbett, Garner, Gass, Gass, Goodwani, Gould, Goulding, Grace, Griffin, Hargreaves, Harris, Henley, Hermann, Hermens, Hodge, Isaac, Jaffrey, Jani, Jin, Joslyn, Kalivas, Kapasova, Kapoor, Karkkainen, Karpyak, Kimpel, Klugmann, Kohda, Konno, Koob, Kornau, Kranzler, Kryger, Krystal, Kuo, Kupila, Lallemand, Lappalainen, Laukkainen, Lester, Levey, Lin, Lin, Loh, Lominac, Long, Lum, Lüscher, Maday, Malenka, Malinow, Mardones, Matsumoto, McBride, McBride, McBride, McBride, McBride, McBride, McBride, McBride, McBride, McBride, McClintick, McCool, Meinhardt, Melendez, Mokdad, Monaghan, Morris, Nevo, Niciu, Obara, Olive, Orth, O’Connor, O’Connor, Patten, Petrakis, Petralia, Preuss, Qrunfleh, Quintero, Rani, Rao, Rao, Reed, Rehm, Rehm, Reich, Reimers, Reissner, Richter, Rietschel, Risher, Rodd, Rodd, Romano, Rothstein, Sala, Sari, Sari, Sari, Sari, Sari, Schnell, Schroeder, Schroeder, Schuckit, Schumann, Selim, Shaw, Sheng, Shigemoto, Shiraishi-Yamaguchi, Spanagel, Staples, Steketee, Swartzwelder, Swartzwelder, Swerdlow, Szumlinski, Szumlinski, Szumlinski, Szumlinski, Tamaru, Tanaka, Tao-Cheng, Tarazi, Terranova, Thoma, Tomita, Traynelis, Van Bockstaele, Vengeliene, Wadiche, Wang, Warburton, Ward, Watterson, Williams, Witzmann, Wong, Worley, Xia, Xiao, Yan, Zamora-Martinez, Zhao, Zhou, Zhou, Ziff   +212 more
core   +1 more source

Optimization of photobiomodulation therapy for spinal cord injury: A review

Photochemistry and Photobiology, EarlyView.
Photobiomodulation (PBM) therapy in the red and near‐infrared range can significantly modulate the secondary injury response and promote the reparative and regenerative potential of neural tissue after spinal cord injury (SCI). At present, due to the nature of delivery methods, the most effective dose and irradiance at the injury site to optimize ...
Isabella K. M. Drew, Alan R. Harvey, Vincent P. Wallace, Stuart I. Hodgetts   +3 more
wiley   +1 more source

Loss of FKBP5 Affects Neuron Synaptic Plasticity: An Electrophysiology Insight [PDF]

, 2019
FKBP5 (FKBP51) is a glucocorticoid receptor (GR) binding protein, which acts as a co-chaperone of heat shock protein 90 (HSP90) and negatively regulates GR.
Deng, Ran, Dou, Longyu, Liang, Tiebing, Liu, Ming, Qiu, Bin, Ren, Wei, Shou, Weinian, Stewart, Robert B., Wang, Chao, Wang, Jun, Williams, Kent E., Xie, Zhongwen, Xu, Yuxue, Yong, Weidong, Zhao, Zhenwen   +14 more
core   +1 more source

Astrocytes: Orchestrators of brain gas exchange and oxygen homeostasis

The Journal of Physiology, EarlyView.
Abstract figure legend Oxygen and carbon dioxide enter the body via breathing; in the brain astrocytes play a key role balancing oxygen delivery with carbon dioxide removal. Abstract If we consider neurons like muscles during exercise, the demand for oxygen (O2) and carbon dioxide (CO2) elimination is constantly changing.
Isabel N. Christie
wiley   +1 more source

Mechanisms of glutamate metabolic function and dysfunction in vascular dementia

Neuroprotection
As the global population ages, research on the pathogenesis and treatment options for older patients with dementia has become increasingly important.
Jiawen Wang, Yingmei Zhang, Ning Tian, Dongshan Ya, Jiaxin Yang, Yanlin Jiang, Xiaoxia Li, Xiaohui Lin, Bin Yang, Qinghua Li, Rujia Liao   +10 more
doaj   +1 more source

Mechanisms associated with activation of intracellular metabotropic glutamate receptor, mGluR5 [PDF]

, 2016
The group 1 metabotropic glutamate receptor, mGluR5, is found on the cell surface as well as on intracellular membranes where it can mediate both overlapping and unique signaling effects.
Jong, Yuh-Jiin I, O\u27Malley, Karen L
core   +2 more sources

Potential health benefits of cold‐water immersion: the central role of PGC‐1α

The Journal of Physiology, EarlyView.
Abstract figure legend Cold‐water immersion (CWI) elicits autonomic, somato‐motoric (shivering thermogenesis), endocrine and metabolic, sensory transduction, and local biophysical effects that may converge on the transcriptional co‐activator PGC‐1α (centre).
Erich Hohenauer, Wafa Douzi, Johannes Burtscher   +2 more
wiley   +1 more source