Results 111 to 120 of about 62,416 (271)

Astrocytes Control Neuronal Excitability in the Nucleus Accumbens

The Scientific World Journal, 2007
Though accumulating evidence shows that the metabotropic glutamate receptor 5 (mGluR5) mediates some of the actions of extracellular glutamate after cocaine use, the cellular events underlying this action are poorly understood.
Tommaso Fellin, Marcello D'Ascenzo, Philip G. Haydon   +2 more
doaj   +1 more source

Type-1 metabotropic glutamate receptor signaling in cerebellar Purkinje cells in health and disease [PDF]

, 2017
Masanobu Kano, Takaki Watanabe
openalex   +1 more source

Bifenthrin Under Scrutiny: Revisiting Toxicological Evidence Amid Regulatory Gaps

Journal of Applied Toxicology, Volume 46, Issue 1, Page 61-77, January 2026.
ABSTRACT Despite growing health concerns, bifenthrin (BF) remains widely used for controlling agricultural and residential pests. However, different perspectives on its toxicological profile and regulatory framework warrant a revisit and update on BF regulation towards a robust risk‐safety assessment.
Caroline V. L. Moreira, John Ogbu I, Kadja L. C. Monteiro, Thiago M. de Aquino, Edeildo F. da Silva‐Júnior, Alberto S. S. Filho, Hamilton B. Napolitano, Christianah A. Elusiyan, Renê O. do Couto, Elson A. Costa, James O. Fajemiroye   +10 more
wiley   +1 more source

Conformational diversity in class C GPCR positive allosteric modulation

Nature Communications
The metabotropic glutamate receptors (mGlus) are class C G protein-coupled receptors (GPCR) that form obligate dimers activated by the major excitatory neurotransmitter L-glutamate.
Giuseppe Cannone, Ludovic Berto, Fanny Malhaire, Gavin Ferguson, Aurelien Fouillen, Stéphanie Balor, Joan Font-Ingles, Amadeu Llebaria, Cyril Goudet, Abhay Kotecha, Vinothkumar K.R., Guillaume Lebon   +11 more
doaj   +1 more source

A PI3K-mediated negative feedback regulates Drosophila motor neuron excitability [PDF]

, 2008
Negative feedback can act as a homeostatic mechanism to maintain neuronal activity at a particular specified value. At the Drosophila neuromuscular junction, a mutation in the type II metabotropic glutamate receptor gene (mGluRA) increased motor neuron ...
Curtis C. J. Lin, Eric Howlett, Michael Stern, William Lavery   +3 more
core   +1 more source

P2X7 receptor antagonism suppresses epileptiform‐like activity in an inflammation‐primed human iPSC‐derived neuron model of drug‐resistant epilepsy

British Journal of Pharmacology, Volume 183, Issue 2, Page 296-312, January 2026.
Background and Purpose Neuroinflammation is increasingly recognised to contribute to drug‐resistant epilepsy. Activation of ATP‐gated P2X7 receptors has emerged as an important upstream mechanism, and increased P2X7 receptor expression is present in the seizure focus in rodent models and patients. Pharmacological antagonists of P2X7 receptors attenuate
Jaideep Kesavan, Yitao Wang, Klaus Dinkel, Michael Hamacher, Jochen H. M. Prehn, David C. Henshall, Tobias Engel   +6 more
wiley   +1 more source

Expanding the Immunologic and Neuronal Landscape of IgE‐Mediated Anaphylaxis

Immunological Reviews, Volume 337, Issue 1, January 2026.
ABSTRACT Anaphylaxis is a life‐threatening immunoglobulin E (IgE)‐mediated type I hypersensitivity reaction with rising prevalence and burden. It involves mast cell degranulation upon cross‐linking of antigen on mast cell‐bound IgE. Mechanisms of IgE‐mediated anaphylaxis remain incompletely understood, particularly the induction of systemic symptoms ...
Ruchi Biswas, Jamie Moore Fried, Maria A. Curotto de Lafaille   +2 more
wiley   +1 more source

Computational Drug Design Applied to the Study of Metabotropic Glutamate Receptors

Molecules, 2019
Metabotropic glutamate (mGlu) receptors are a family of eight GPCRs that are attractive drug discovery targets to modulate glutamate action and response. Here we review the application of computational methods to the study of this family of receptors.
Claudia Llinas del Torrent, Laura Pérez-Benito, Gary Tresadern   +2 more
doaj   +1 more source

Metabotropic glutamate receptors: Phosphorylation and receptor signaling

Journal of Neuroscience Research, 2007
AbstractMetabotropic glutamate receptors (mGluRs) play important roles in neurotransmission, neuronal development, synaptic plasticity, and neurological disorders. Recent studies have revealed a sophisticated interplay between mGluRs and protein kinases: activation of mGluRs regulates the activity of a number of kinases, and direct phosphorylation of ...
Chul Hoon, Kim, Jinu, Lee, Jae-Youn, Lee, Katherine W, Roche   +3 more
openaire   +3 more sources

Characterizing Spatial Associations Between GluCEST MRI and Neurotransmitter Receptor Density in the Human Cortex

Human Brain Mapping, Volume 46, Issue 18, 15 December 2025.
We leveraged in vivo 7T GluCEST MRI and normative PET receptor maps to examine the spatial covariation between cortical glutamate levels and receptor expression. GluCEST signal showed positive spatial associations with NMDA and GABAA, but not mGluR5. These findings enhance our understanding of GluCEST and glutamate‐receptor dynamics across the cortex ...
Maggie K. Pecsok, Golia Shafiei, Ally Atkins, Monica E. Calkins, Ruben C. Gur, Ravi Prakash Reddy Nanga, Ravinder Reddy, Melanie A. Matyi, Jacquelyn Stifelman, Heather Robinson, Erica B. Baller, Russell T. Shinohara, Kosha Ruparel, Kristin A. Linn, Daniel H. Wolf, Theodore D. Satterthwaite, Corey T. McMillan, David Roalf   +17 more
wiley   +1 more source