Results 121 to 130 of about 62,416 (271)

Glutamate Receptor Signaling in Retina Müller Cells: Plausible Role in Neurodegeneration

Receptors
The retinal network relies on glutamate, the primary excitatory neurotransmitter involved in the visual cycle. Glutamate transactions are carried out by an array of distinct receptors and transporters distributed across both pre- and post-synaptic ...
Bolaji Oyetayo, Yurixy Mendoza-Silva, Temitayo Subair, Luisa C Hernández-Kelly, Marie-Paule Felder-Schmittbuhl, Tatiana N. Olivares-Bañuelos, Arturo Ortega   +6 more
doaj   +1 more source

Neurotoxic Agent-Induced Injury in Neurodegenerative Disease Model: Focus on Involvement of Glutamate Receptors

Frontiers in Molecular Neuroscience, 2018
Glutamate receptors play a crucial role in the central nervous system and are implicated in different brain disorders. They play a significant role in the pathogenesis of neurodegenerative diseases (NDDs) such as Alzheimer’s disease, Parkinson’s disease,
Md. Jakaria, Shin-Young Park, Md. Ezazul Haque, Govindarajan Karthivashan, In-Su Kim, Palanivel Ganesan, Palanivel Ganesan, Dong-Kug Choi, Dong-Kug Choi, Dong-Kug Choi   +9 more
doaj   +1 more source

Exocytosis of Vesicular Zinc Reveals Persistent Depression of Neurotransmitter Release during Metabotropic Glutamate Receptor Long-Term Depression at the Hippocampal CA3–CA1 Synapse [PDF]

, 2006
Jing Qian, Jeffrey L. Noebels
openalex   +1 more source

Infrared Neural Stimulation Elicits Distinct Molecular Pathways in Astrocytes Based on Laser Pulse Parameters

Advanced Biology, Volume 9, Issue 12, December 2025.
Infrared (IR) light evokes distinct calcium and water transport responses in astrocytes, depending on stimulation duration and protocol. This study uses widefield imaging and pharmacology to reveal differential engagement of astroglial signaling pathways.
Wilson R. Adams, Ana I Borrachero‐Conejo, Pratheepa Kumari Rasiah, Emanuela Saracino, Roberto Zamboni, Eric Duco Jansen, Valentina Benfenati, Anita Mahadevan‐Jansen   +7 more
wiley   +1 more source

Plasticity of GABA(B) receptor-mediated heterosynaptic interactions at mossy fibers after status epilepticus [PDF]

, 2003
Several neurotransmitters, including GABA acting at presynaptic GABAB receptors, modulate glutamate release at synapses between hippocampal mossy fibers and CA3 pyramidal neurons.
Bowery, N.G., Chandler, K.E., Fabian-Fine, R., Kullmann, D.M., Princivalle, A.P., Walker, M.C.   +5 more
core  

Activation of GABAB receptors attenuate Alzheimer's disease related pathophysiology in a preclinical APP/PS1 transgenic model

Alzheimer's &Dementia, Volume 21, Issue S1, December 2025.
Abstract Background Alongside the major hallmarks of Alzheimer's disease (AD) – amyloid beta (Aβ) plaque, tau tangles, and neurodegeneration – hippocampal synapse loss also presents as a pathological phenotype in this disorder. While there is extensive research linking synapse loss to hyperexcitability and glutamate excitotoxicity, there is a gap in ...
Colin J McArdle, Abigail Caudill, Kimberly F Raab‐Graham   +2 more
wiley   +1 more source

Reduction of Glutamatergic Neurotransmission by Prolonged Exposure to Dieldrin Involves NMDA Receptor Internalization and Metabotropic Glutamate Receptor 5 Downregulation [PDF]

, 2009
Víctor Briz, Mireia Galofré, Cristina Suñol   +2 more
openalex   +1 more source

Alzheimer's disease is associated with changes in the metabotropic glutamate mGlu3 receptor expression but not with SNPs in the GRM3 gene

Alzheimer's &Dementia, Volume 21, Issue S2, December 2025.
Abstract Background Our group has demonstrated that the subtype 3 metabotropic glutamate receptor (mGlu3R) expressed in astrocytes exerts neuroprotective functions and promotes both non‐amyloidogenic cleavage of APP and Aβ clearance. In turn, we showed that mGlu3R levels progressively decreased with age in the hippocampus of PDAPP‐J20 murine AD model ...
Eugenia Olivera, Pilar Garaventa, Albany Saez, Ana Clara Romero, Daniela Zelaya, Mercedes Bigi, Carla Caruso, Juan Beauquis, Flavia Saravia, Mercedes Lasaga, Daniela Durand   +10 more
wiley   +1 more source

Common Mechanisms Underlying Opioid Tolerance and Dependence and Neuropathic Pain: Role of Metabotropic Glutamate Receptors

Pain Research and Management, 2000
It has been suggested that opioid tolerance and dependence share common mechanisms with neuropathic pain. This short review deals with the role of glutamate and glutamate receptors in opioid tolerance and dependence, and neuropathic pain.
Marian E Fundytus
doaj   +1 more source

Buried Treasure? Overlooked and Newly Discovered Evolutionary Contributions to Human Brain Diseases

Annals of Neurology, Volume 98, Issue 6, Page 1178-1195, December 2025.
[Color figure can be viewed at www.annalsofneurology.org] Recapitulative schema of different exploratory levels of the evolutionary impact on human neurological diseases. Clinical neuroscience focuses on the mechanisms of brain function, but this approach falls short of insights into how the central nervous system (CNS) evolved, both in health and ...
Nico J. Diederich, Martin Brüne, John S. Allen, Nicole Bender, Emiliano Bruner, Jean‐Pierre Changeux, Corrado Cali, Olga Dolgova, Anne Grünewald, Geneviève Konopka, Peng Jin, Roger Lemon, Gilberto Levy, Pierre Magistretti, Markus J. Rantala, Kathleen S. Rockland, Roger Sullivan, Annie Swanepoel, Toshiki Uchihara, Katrin Amunts, Christopher G. Goetz   +20 more
wiley   +1 more source