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Correction to: Group I and group II metabotropic glutamate receptors are upregulated in the synapses of infant rats prenatally exposed to valproic acid. [PDF]
D'Antoni S+9 more
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Preso1 dynamically regulates group I metabotropic glutamate receptors
Jia-hua Hu+13 more
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M. Lavialle+5 more
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Activity-Dependent Activation of Presynaptic Metabotropic Glutamate Receptors in Locus Coeruleus
Gilles Dubé, K.C. Marshall
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Pharmacology and functions of metabotropic glutamate receptors.
Annual Review of Pharmacology and Toxicology, 1997▪ Abstract In the mid to late 1980s, studies were published that provided the first evidence for the existence of glutamate receptors that are not ligand-gated cation channels but are coupled to effector systems through GTP-binding proteins. Since those initial reports, tremendous progress has been made in characterizing these metabotropic glutamate ...
Conn Pj, J. Pin
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The metabotropic glutamate receptors: Structure and functions
Neuropharmacology, 1995Glutamate is the main excitatory neurotransmitter in the brain. For many years it has been considered to act only on ligand-gated receptor channels--termed NMDA, AMPA and kainate receptors--involved in the fast excitatory synaptic transmission. Recently, glutamate has been shown to regulate ion channels and enzymes producing second messengers via ...
J. Pin, R. Duvoisin
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Dynamics and modulation of metabotropic glutamate receptors.
Current Opinion in Pharmacology, 2015The metabotropic glutamate receptors (mGluRs) are glutamate-activated G protein-coupled receptors widely expressed in the central nervous system. The eight mGluRs subtypes modulate transmission at many synapses, and are interesting therapeutic targets for the treatment of many neurological and psychiatric diseases.
P. Rondard, J. Pin
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A family of metabotropic glutamate receptors
Neuron, 1992Three cDNA clones, mGluR2, mGluR3, and mGluR4, were isolated from a rat brain cDNA library by cross-hybridization with the cDNA for a metabotropic glutamate receptor (mGluR1). The cloned receptors show considerable sequence similarity with mGluR1 and possess a large extracellular domain preceding the seven putative membrane-spanning segments. mGluR2 is
Y. Tanabe+4 more
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Pharmacological Reviews, 2020
Metabotropic glutamate (mGlu) receptors respond to glutamate, the major excitatory neurotransmitter in the mammalian brain, mediating a modulatory role that is critical for higher-order brain functions such as learning and memory.
K. Gregory, C. Goudet
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Metabotropic glutamate (mGlu) receptors respond to glutamate, the major excitatory neurotransmitter in the mammalian brain, mediating a modulatory role that is critical for higher-order brain functions such as learning and memory.
K. Gregory, C. Goudet
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