Results 241 to 250 of about 62,416 (271)

Metabotropic glutamate receptors

Cell and Tissue Research, 2006
Metabotropic glutamate receptors (mGlus) are a family of G-protein-coupled receptors activated by the neurotransmitter glutamate. Molecular cloning has revealed eight different subtypes (mGlu1-8) with distinct molecular and pharmacological properties. Multiplicity in this receptor family is further generated through alternative splicing. mGlus activate
Ferraguti F., Shigemoto R.
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Metabotropic glutamate receptors

Pharmacology Biochemistry and Behavior, 2002
Abstract Glutamate, like other neurotransmitters (acetylcholine, ATP, serotonine, glycine, GABA), acts on two main types of membrane receptors: ligand-gated channels, also called ionotropic receptors (iGluRs), and G protein coupled receptors also called metabotropic glutamate receptors (mGluRs).
Darryle D Schoepp, P.Jeffrey Conn
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A family of metabotropic glutamate receptors

Neuron, 1992
Three cDNA clones, mGluR2, mGluR3, and mGluR4, were isolated from a rat brain cDNA library by cross-hybridization with the cDNA for a metabotropic glutamate receptor (mGluR1). The cloned receptors show considerable sequence similarity with mGluR1 and possess a large extracellular domain preceding the seven putative membrane-spanning segments. mGluR2 is
Y, Tanabe, M, Masu, T, Ishii, R, Shigemoto, S, Nakanishi   +4 more
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Structure of the metabotropic glutamate receptor

Current Opinion in Neurobiology, 2003
In the twelve years since the molecular elucidation of the metabotropic glutamate receptor subtype 1, a class III family of G-protein-coupled receptors has emerged; members of this family include the calcium-sensing receptor, the GABA(B) receptor, some odorant receptors and some taste receptors.
Hisato, Jingami, Shigetada, Nakanishi, Kosuke, Morikawa   +2 more
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Metabotropic glutamate receptors and epilepsy

Journal of the Neurological Sciences, 2006
Metabotropic glutamate receptors (mGluRs) play an important role in the initiation of ictal discharges by participating in the interictal-ictal transition, and may play a crucial role in recruiting normal brain tissue into synchronized discharges, thereby facilitating propagation of seizure activity.
Jorge, Ure, Michel, Baudry, Mónica, Perassolo   +2 more
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Metabotropic Glutamate Receptors and Neurodegeneration

2004
Metabotropic glutamate (mGlu) receptors, which exert a modulatory effect on excitatory synaptic transmission, are considered as potential targets for neuroprotective drugs and the advent of potent and centrally available subtype-selective ligands has lead to an extensive investigation of the role of individual mGlu receptor subtypes in ...
BRUNO, Valeria Maria Gloria, BATTAGLIA, Giuseppe, NICOLETTI, Ferdinando   +2 more
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Metabotropic Glutamate Receptors

Amino Acids, 2007
l-Glutamate, one of the main neurotransmitters in the central nervous system (CNS), acts on two groups of receptors: (a) a group of ionotropic receptors that includes N-methyl-d-aspartate (NMDA), α-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA), and kainate receptors, and (2) a group of metabotropic receptors (mGluRs).
A. Pilc, K. Ossowska
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Metabotropic glutamate receptors and neurodegeneration.

Progress in brain research, 1998
Metabotropic glutamate (mGlu) receptors belong to a class of G-protein linked receptors, which also includes the Ca2+-sensing receptor and the gama-aminobutyric acid (GABAB) receptor. A great variety of drugs has been introduced with the intent of limiting some of the intracellular events that occur downstream of the increase in intracellular Ca2 ...
BRUNO, Valeria Maria Gloria, BATTAGLIA, Giuseppe, A. Copani, G. Casabona, M. Storto, V. D. Giorgi, R. Ngomba, NICOLETTI, Ferdinando   +7 more
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Metabotropic Glutamate Receptors and Neuronal Toxicity

1992
Specific glutamate receptors coupled to polyphosphoinositide (PPI) hydrolysis have been described in brain slices, cultured neurons, and astrocytes, and in amphibian oocytes injected with rat brain mRNA (Sladeczek et al., 1985; Nicoletti et al., 1986a,b; Sugiyama et al., 1987).
ALEPPO G, PISANI A, COPANI A, BRUNO V, ARONICA E, D'AGATA V, CANONICO P. L, NICOLETTI F   +7 more
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Modulation of Excitation by Metabotropic Glutamate Receptors

2007
Metabotropic glutamate receptors, in contrast to ionotropic glutamate receptors, do not form ion channels but instead affect intracellular chemical messenger systems. They couple via GTP-binding proteins ("G-proteins") to a variety of effectors such as ion channels and thus give glutamate, the major excitatory transmitter in the CNS, the ability to ...
Thomas, Knöpfel, Marylka, Uusisaari
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