Results 251 to 260 of about 114,351 (281)

Metabotropic Glutamate Receptors and Neuronal Toxicity

1992
Specific glutamate receptors coupled to polyphosphoinositide (PPI) hydrolysis have been described in brain slices, cultured neurons, and astrocytes, and in amphibian oocytes injected with rat brain mRNA (Sladeczek et al., 1985; Nicoletti et al., 1986a,b; Sugiyama et al., 1987).
ALEPPO G, PISANI A, COPANI A, BRUNO V, ARONICA E, D'AGATA V, CANONICO P. L, NICOLETTI F   +7 more
openaire   +6 more sources

The Structures of Metabotropic Glutamate Receptors [PDF]

, 2008
Interest in the structures of the metabotropic glutamate receptors continues to increase for a variety of reasons, including the fact that they are now established drug targets and are linked to a wide spectrum of physiologic processes both within and outside the central nervous system.
Erin M. Rose, David R. Hampson, Jordan E. Antflick   +2 more
openaire   +1 more source

2008 Eruptions in metabotropic glutamate receptors

Neuropharmacology, 2008
[No abstract available]
NICOLETTI, Ferdinando, Graham Collingridge, Darryle Schoepp   +2 more
openaire   +4 more sources

The metabotropic glutamate receptors of the vestibular organs

Hearing Research, 1998
This research sought to test the presence and function of metabotropic excitatory amino acid receptors (mGluR) in the frog semicircular canal (SCC). The mGluR agonist +/- 1-aminocyclopentane-trans-1,3-dicarboxylate (ACPD) produced an increase in afferent firing rates of the ampullar nerve of the intact posterior canal.
Paola Perin, Paola Perin, Meredith M. Garcia, Paul S. Guth, G. Zucca, Paolo Valli, Amrita Puri, Laura Botta, Grace B. Athas, Joseph C. Holt   +9 more
openaire   +4 more sources

Effects of bromohomoibotenate on metabotropic glutamate receptors

NeuroReport, 1994
(S)-Bromohomoibotenic acid [(S)-BrHIbo] stereoselectively antagonized glutamate-stimulated phosphoinositide (PI) hydrolysis in baby hamster kidney (BHK) cells expressing mGluR1a in a competitive manner with an IC50 of 250 microM. However, (S)-BrHIbo did not inhibit (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid [(1S,3R)-ACPD]-induced PI hydrolysis ...
Peter D. Suzdak, Christian Foged, Christian Thomsen, Anne Bau, Peter Faarup, Anders Kanstrup   +5 more
openaire   +3 more sources

Metabotropic glutamate receptors in vertebrate retina

Documenta Ophthalmologica, 2003
A striking feature in visual information processing is the fact that the primary signaling elements, the rods and the cones, are hyperpolarized and thus inhibited by light, the physiological stimulus. Light effectively shuts down neurotransmitter release by the photoreceptors onto the second-order retinal neurons.
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Metabotropic Glutamate Receptors: Gatekeepers of Homeostasis

Journal of Neuroendocrinology, 2010
The capacity to appropriately respond to physiological challenges or perturbations in homeostasis is a requisite for survival. It is becoming increasingly clear that long‐lasting alterations in synaptic efficacy are a fundamental mechanism for modifying neuroendocrine and autonomic output. We review recent advances in our understanding of plasticity at
Jaideep S. Bains, J. B. Kuzmiski
openaire   +3 more sources

Structures of Gi-bound metabotropic glutamate receptors mGlu2 and mGlu4

Nature, 2021
Shuling Lin, Shuo Han, Xiao-qing Cai, Q. Tan, Kexiu Zhou, Dejian Wang, Xinwei Wang, Juan Du, C. Yi, Xiaojing Chu, A. Dai, Yan Zhou, Yan Chen, Yu Zhou, Hong Liu, Jianfeng Liu, Dehua Yang, Ming-Wei Wang, Qiang Zhao, Beili Wu   +19 more
semanticscholar   +1 more source

Modulation of Excitation by Metabotropic Glutamate Receptors

2007
Metabotropic glutamate receptors, in contrast to ionotropic glutamate receptors, do not form ion channels but instead affect intracellular chemical messenger systems. They couple via GTP-binding proteins ("G-proteins") to a variety of effectors such as ion channels and thus give glutamate, the major excitatory transmitter in the CNS, the ability to ...
Marylka Uusisaari, Thomas Knöpfel
openaire   +3 more sources

Get receptive to metabotropic glutamate receptors

Current Opinion in Neurobiology, 1995
Glutamate activates not only ionotropic glutamate receptors, but also G-protein-coupled receptors, called metabotropic glutamate receptors. Recent studies have revealed that these metabotropic receptors share distinctive structural properties and that they form a subgroup within the heptahelical receptor family.
Jean-Philippe Pin, Joël Bockaert
openaire   +3 more sources