Results 51 to 60 of about 114,184 (367)

Modeling T1 Resting-State MRI Variants Using Convolutional Neural Networks in Diagnosis of OCD [PDF]

arXiv, 2023
Obsessive-compulsive disorder (OCD) presents itself as a highly debilitating disorder. The disorder has common associations with the prefrontal cortex and the glutamate receptor known as Metabotropic Glutamate Receptor 5 (mGluR5). This receptor has been observed to demonstrate higher levels of signaling from positron emission tomography scans measured ...
arxiv  

Increased accuracy of ligand sensing by receptor diffusion on cell surface [PDF]

Physical Review E 82, 041902 (2010), 2010
The physical limit with which a cell senses external ligand concentration corresponds to the perfect absorber, where all ligand particles are absorbed and overcounting of same ligand particles does not occur. Here we analyze how the lateral diffusion of receptors on the cell membrane affects the accuracy of sensing ligand concentration.
arxiv   +1 more source

Practical Strategies and Concepts in GPCR Allosteric Modulator Discovery: Recent Advances with Metabotropic Glutamate Receptors.

Chemical Reviews, 2016
Allosteric modulation of GPCRs has initiated a new era of basic and translational discovery, filled with therapeutic promise yet fraught with caveats. Allosteric ligands stabilize unique conformations of the GPCR that afford fundamentally new receptors ...
C. Lindsley, K. Emmitte, C. Hopkins, T. Bridges, K. J. Gregory, C. Niswender, C. Niswender, P. J. Conn, P. J. Conn   +8 more
semanticscholar   +1 more source

Permissive role for mGlu1 metabotropic glutamate receptors in excitotoxic retinal degeneration [PDF]

, 2017
Neuroprotection is an unmet need in eye disorders characterized by retinal ganglion cell (RGC) death, such as prematurity-induced retinal degeneration, glaucoma, and age-related macular degeneration.
Battaglia, Giuseppe, Beneventano, Martina, Bruno, Valeria, Bucci, Domenico, Di Pietro, Paola, Liberatore, Francesca, Madonna, Michele, Mascio, Giada, Nicoletti, Ferdinando, Puliti, Alda Maria, Romano, Maria Rosaria   +10 more
core   +1 more source

Towards the convergent therapeutic potential of GPCRs in autism spectrum disorders [PDF]

arXiv, 2022
Changes in genetic and/or environmental factors to developing neural circuits and subsequent synaptic functions are known to be a causative underlying the varied socio-emotional behavioural patterns associated with autism spectrum disorders (ASD). Seven transmembrane G protein-coupled receptors (GPCRs) comprising the largest family of cell-surface ...
arxiv  

Direct imaging of lateral movements of AMPA receptors inside synapses [PDF]

EMBO J 22, 18 (15/09/2003) 4656-65, 2007
Trafficking of AMPA receptors in and out of synapses is crucial for synaptic plasticity. Previous studies have focused on the role of endo/exocytosis processes or that of lateral diffusion of extra-synaptic receptors. We have now directly imaged AMPAR movements inside and outside synapses of live neurons using single-molecule fluorescence microscopy ...
arxiv   +1 more source

Glutamatergic Mechanisms in Glioblastoma and Tumor-Associated Epilepsy

Cells, 2021
The progression of glioblastomas is associated with a variety of neurological impairments, such as tumor-related epileptic seizures. Seizures are not only a common comorbidity of glioblastoma but often an initial clinical symptom of this cancer entity ...
Falko Lange, Max Frederik Hörnschemeyer, Timo Kirschstein   +2 more
doaj   +1 more source

Contribution of Cystine-Glutamate Antiporters to the Psychotomimetic Effects of Phencyclidine [PDF]

, 2008
Altered glutamate signaling contributes to a myriad of neural disorders, including schizophrenia. While synaptic levels are intensely studied, nonvesicular release mechanisms, including cystine–glutamate exchange, maintain high steady-state glutamate ...
A Baskys, A Breier, A Meister, A Meister, AJ Cochilla, AK Malhotra, Aric Madayag, AW MacDonald III, AY Shih, B Moghaddam, B Moghaddam, D Jabaudon, DA Baker, DA Baker, David A Baker, DC Javitt, DD Schoepp, DD Schoepp, DE Featherstone, DM Barch, DP Purohit, DR Weinberger, DS Gupta, DS Lorrain, E Pileblad, ED Luby, F Faltus, F Sams-Dodd, G Hu, G Hu, G Kohr, G Paxinos, GD Pearlson, GJ Marek, H Augustin, H Homayoun, H Sato, H Sies, HB Uylings, HF Bradford, Ilangovan Raju, J Cartmell, J Kilbride, JA Lieberman, James H Meador-Woodruff, JB Manent, JH Cabungcal, JH Krystal, JH Krystal, JM Williamson, JY Kim, K Aoyama, KQ Do, L Lu, Lars V Kristiansen, LE Chavez-Noriega, M D'Ascenzo, M Herrera-Marschitz, M Verhage, ME Jackson, MM Moran, O Valenti, P Steullet, PD Harvey, R Corbett, R Takahata, S Bannai, S Chaki, SA Petersen, SJ Sigrist, SM Deneke, Vahram Haroutunian, W Hauber, W Timmerman, WA Abbott, WE Bunney, Y Huang, ZX Xi, ZX Xi   +78 more
core   +2 more sources

A Light-Controlled Allosteric Modulator Unveils a Role for mGlu4 Receptors During Early Stages of Ischemia in the Rodent Cerebellar Cortex

Frontiers in Cellular Neuroscience, 2018
Metabotropic glutamate receptors (mGlus) are G Protein coupled-receptors that modulate synaptic transmission and plasticity in the central nervous system.
Simon Bossi, Romain Helleringer, Micaela Galante, Ester Monlleó, Ana Trapero, Xavier Rovira, Hervé Daniel, Amadeu Llebaria, Heather McLean   +8 more
doaj   +1 more source

High- and low-conductance NMDA receptors are present in layer 4 spiny stellate and layer 2/3 pyramidal neurons of mouse barrel cortex [PDF]

Physiological Reports, 30th Dec. 2016, Vol. 4 no. e13051, 2016
NMDA receptors are ion channels activated by the neurotransmitter glutamate in the mammalian brain and are important in synaptic function and plasticity, but are also found in extrasynaptic locations and influence neuronal excitability. There are different NMDA receptor subtypes which differ in their single-channel conductance.
arxiv   +1 more source